Dual Scan Mammoscope (DSM)—A New Portable Photoacoustic Breast Imaging System With Scanning in Craniocaudal Plane

Nyayapathi, Nikhila; Lim, Rachel Su Ann; Zhang, Huijuan; Zheng, Wenhan; Wang, Yuehang; Tiao, Melinda; Oh, Kwang W.; Fan, Xiao Xu; Bonaccio, Ermelinda; Takabe, Kazuaki; Xia, Jun

doi:10.1109/tbme.2019.2936088

Cited by 48 publications

(34 citation statements)

References 40 publications

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“…Current results indicate that using multiple light illumination angles, along with optimizing imaging geometry can improve light penetration. 34,51 In addition to that, engineering PA-based contrast agents could be another solution to facilitate deep tissue imaging. [85][86][87] Second, although multispectral PA imaging enables the functional quantification of breast tissue, the complexity of light absorption and scattering in tissue make the quantification inaccurate.…”

Section: Discussionmentioning

confidence: 99%

“…31,32 The planar detection is implemented using a small planar array 33 or by scanning the object with a linear array. 34 Apart from classification based on imaging geometry, the systems can also be categorized based on the scanning mechanism, i.e., handheld imaging systems and tomographic imaging systems. In handheld systems, the imaging probe can be used similar to a clinical breast US, whereas in tomographic imaging systems, the US probe is connected to a motorized stage for automated scanning.…”

Section: Imaging Systemsmentioning

confidence: 99%

“…The dual-scan mammoscope (DSM) proposed by Nyayapathi et al is a double-sided-view planar imaging system. 34 It uses two linear array transducers to scan the breast in the CC plane. The breast is gently compressed between two water tanks, with the patient standing upright.…”

Section: Planar Imaging Systemsmentioning

confidence: 99%

“…The data acquired from both transducers are combined and aligned to completely visualize the vascular structures in the compressed breast region. This is the first system to report PA imaging of human breast through a field of view of 7-cm deep into the breast, 34 as shown in Fig. 2(b).…”

Section: Planar Imaging Systemsmentioning

confidence: 99%

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Photoacoustic imaging of breast cancer: a mini review of system design and image features

Nyayapathi

Xia

2019

J. Biomed. Opt.

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Breast cancer is one of the leading causes for cancer related deaths in women, and early detection is extremely important to improve survival rates. Currently, x-ray mammogram is the only modality for mass screening of asymptomatic women. However, it has decreased sensitivity in radiographically dense breasts, which is also associated with a higher risk for breast cancer. Photoacoustic (PA) imaging is an emerging modality that enables deep tissue imaging of optical contrast at ultrasonically defined spatial resolution, which is much higher than that can be achieved in purely optical imaging modalities. Because of high optical absorption from hemoglobin molecules, PA imaging can map out hemo distribution and dynamics in breast tissue and identify malignant lesions based on tumor associated angiogenesis and hypoxia. We review various PA breast imaging systems proposed over the past few years and summarize the PA features of breast cancer identified in these systems.

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Section: Discussionmentioning

confidence: 99%

Section: Imaging Systemsmentioning

confidence: 99%

Section: Planar Imaging Systemsmentioning

confidence: 99%

Section: Planar Imaging Systemsmentioning

confidence: 99%

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Photoacoustic imaging of breast cancer: a mini review of system design and image features

Nyayapathi

Xia

2019

J. Biomed. Opt.

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“…Compared to the 2D array probe, it is much easier to manufacture a linear array with smaller element size, as well as its parallel data acquisition system. Nikhila et al [22] presented a dual scan mammoscope system by two focused array, and they employed the "virtual line" algorithm to successfully improve the elevation resolution. But the inherent focusing characteristic of this probe still limits its effective acquisition angle, making it difficult to image vertically obliquely aligned targets in 3D.…”

Section: Introductionmentioning

confidence: 99%

Developing a Photoacoustic Whole-Breast Imaging System Based on the Synthetic Matrix Array

Zhang

Yang

et al. 2020

Front. Phys.

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In this study, we reported a photoacoustic (PA) imaging system for whole-breast imaging. Similar to the traditional X-ray mammography, this system slightly compressed the breast by a water tank. The PA signal is acquired via scanning a long unfocused ultrasonic linear array probe over the breast top surface, and the expanded high-energy laser pulses illuminate the breast bottom through a transparent supporting plate. Scanning the unfocused transducer probe is equivalent to a synthetic two-dimensional (2D) matrix array, which significantly increased the field of view (FOV) via a much easier way and at a much lower cost. Our phantom results demonstrated that this system has a great potential for clinical implementation.

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Deep Learning Enhanced Volumetric Photoacoustic Imaging of Vasculature in Human

Zheng,

Zhang,

Huang

et al. 2023

Advanced Science

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The development of high‐performance imaging processing algorithms is a core area of photoacoustic tomography. While various deep learning based image processing techniques have been developed in the area, their applications in 3D imaging are still limited due to challenges in computational cost and memory allocation. To address those limitations, this work implements a 3D fully‐dense (3DFD) U‐net to linear array based photoacoustic tomography and utilizes volumetric simulation and mixed precision training to increase efficiency and training size. Through numerical simulation, phantom imaging, and in vivo experiments, this work demonstrates that the trained network restores the true object size, reduces the noise level and artifacts, improves the contrast at deep regions, and reveals vessels subject to limited view distortion. With these enhancements, 3DFD U‐net successfully produces clear 3D vascular images of the palm, arms, breasts, and feet of human subjects. These enhanced vascular images offer improved capabilities for biometric identification, foot ulcer evaluation, and breast cancer imaging. These results indicate that the new algorithm will have a significant impact on preclinical and clinical photoacoustic tomography.

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Dual Scan Mammoscope (DSM)—A New Portable Photoacoustic Breast Imaging System With Scanning in Craniocaudal Plane

Cited by 48 publications

References 40 publications

Photoacoustic imaging of breast cancer: a mini review of system design and image features

Photoacoustic imaging of breast cancer: a mini review of system design and image features

Developing a Photoacoustic Whole-Breast Imaging System Based on the Synthetic Matrix Array

Deep Learning Enhanced Volumetric Photoacoustic Imaging of Vasculature in Human

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