Dual scale biomechanics of extracellular matrix proteins probed by Brillouin scattering and quasistatic tensile testing

Edginton, Ryan S.; Green, Ellen M.; Winlove, C. Peter; Fioretto, D.; Palombo, Francesca

doi:10.1117/12.2290183

Cited by 2 publications

(1 citation statement)

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“…68−70 Our works on type-I collagen and elastin fibers, articular cartilage and nuchal ligament, have gained insights into the mechanical anisotropy of fibrous proteins of the extracellular matrix (ECM) and on the effect of hydration on the Brillouin peaks. 13,71,72 It was found that water plays a prominent role in the dynamics and spectral features in Brillouin scattering that can mask mechanical anisotropy when signals are very close to the water modes. All these studies, focused on elastic properties of the ECM and connective tissue, are critical for the interpretation of Brillouin-derived quantities for whole tissue analysis.…”

Section: Advances In Brillouin Scattering Methodsmentioning

confidence: 99%

Brillouin Light Scattering: Applications in Biomedical Sciences

2019

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Brillouin spectroscopy and imaging are emerging techniques in analytical science, biophotonics, and biomedicine. They are based on Brillouin light scattering from acoustic waves or phonons in the GHz range, providing a nondestructive contactless probe of the mechanics on a microscale. Novel approaches and applications of these techniques to the field of biomedical sciences are discussed, highlighting the theoretical foundations and experimental methods that have been developed to date. Acknowledging that this is a fast moving field, a comprehensive account of the relevant literature is critically assessed here.

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