Dual roles of yes-associated protein (YAP) in colorectal cancer

Ou, Chunlin; Sun, Zhenqiang; Shen, Li; Li, Guiyuan; Li, Xiayu; Ma, Jian

doi:10.18632/oncotarget.20155

Cited by 48 publications

(43 citation statements)

References 193 publications

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“…In 2015, 777,987 new cases and 352,589 deaths occurred due to CRC [30]. With the development of basic and clinical investigations, the mechanisms of CRC and therapeutic strategies involved have become better understood [31]. Nevertheless, due to postsurgical recurrence and metastasis of primary tumours, CRC mortality and morbidity rates remain high.…”

Section: Discussionmentioning

confidence: 99%

Up-regulation of LINC00467 promotes the tumourigenesis in colorectal cancer

He¹,

Shen²,

Yu³

et al. 2019

J. Cancer

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Recent studies have reported that long non-coding RNAs (lncRNAs) are associated with the tumourigenesis of colorectal cancer (CRC); however, several of these are yet to be identified and characterised. In this study, we report a novel lncRNA, LINC00467, which was significantly up-regulated in CRC; we investigated its function and mechanism in CRC. Our study demonstrated that LINC00467 levels in 45 pairs of CRC tissues were higher than those in the corresponding normal colon mucosal tissues. We used the Gene Expression Omnibus (GEO) and Gene Expression Profiling Interactive Analysis (GEPIA) databases for the analysis and measurement of clinical samples, and observed that the CRC patients with high LINC00467 expression levels showed poor overall survival (OS) and recurrent-free survival (RFS) rates. Furthermore, following the short interfering RNA (siRNA) knockdown of LINC00467 in the CRC cell line, the results demonstrated that LINC00467 suppresses the proliferation, invasion and metastasis of CRC cells in vitro. Moreover, its molecular mechanism of LINC00467 decreased the expression of Cyclin D1, Cyclin A1, CDK2, CDK4 and Twist1 as well as enhanced the expression of E-cadherin. Collectively, these findings suggest that LINC00467 may be crucial in the progression and development of CRC, and may serve as a potential therapeutic target for CRC patients.

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Section: Discussionmentioning

confidence: 99%

Up-regulation of LINC00467 promotes the tumourigenesis in colorectal cancer

He¹,

Shen²,

Yu³

et al. 2019

J. Cancer

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“…A recent review has highlighted the bilateral roles of Yap, as both a tumor suppressor and an oncogene in CRC. Nuclear Yap overexpression has been observed in various cancers, including CRC, and correlates inversely with OS and DFS .…”

Section: Introductionmentioning

confidence: 99%

Searching for the link; mechanisms underlying liver regeneration and recurrence of colorectal liver metastasis post partial hepatectomy

Riddiough

Fifis

Muralidharan

et al. 2019

J of Gastro and Hepatol

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Despite excellent treatment of primary colorectal cancer, the majority of deaths occur as a result of metastasis to the liver. Recent population studies have estimated that one quarter of patients with colorectal cancer will incur synchronous or metachronous colorectal liver metastasis. However, only one quarter of these patients will be eligible for potentially curative resection. Tumor recurrence occurs in reportedly 60% of patients undergoing hepatic resection, and the majority of intrahepatic recurrence occurs within the first 6 months of surgery. The livers innate ability to restore its homeostatic size, and volume facilitates major hepatic resection that currently offers the only chance of cure to patients with extensive hepatic metastases. Experimental and clinical evidence supports the notion that following partial hepatectomy, liver regeneration (LR) paradoxically drives tumor progression and increases the risk of recurrence. It is becoming increasingly clear that the processes that drive liver organogenesis, regeneration, and tumor progression are inextricably linked. This presents a major hurdle in the management of colorectal liver metastasis and other hepatic malignancies because therapies that reduce the risk of recurrence without hampering LR are sought. The processes and pathways underlying these phenomena are multiple, complex, and cross‐communicate. In this review, we will summarize the common mechanisms contributing to both LR and tumor recurrence.

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“…Many studies have shown that YAP is an oncogenic gene, which is highly expressed in various tumors and can regulate tumor progression. 23 – 25 Nuclear YAP can promote cancer cell proliferation, apoptosis, metastasis, and maintenance of stemness by interacting with other transcription factors and affecting tumor progression. Therefore, YAP has the prospect of being a new tumor biomarker or therapeutic target for CRC.…”

Section: Introductionmentioning

confidence: 99%

CCNA2 acts as a novel biomarker in regulating the growth and apoptosis of colorectal cancer

Gan¹,

Li²,

Li³

et al. 2018

CMAR

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ObjectiveColorectal cancer (CRC) is considered to be the most prevalent malignant tumors that contribute to high cancer-related mortality. However, the signaling pathways involved in CRC and CRC-driven genes are largely unknown. We seek to discover a novel biomarker in CRC.Materials and methodsAll clinical CRC samples (n=33) were from Xiangya Hospital. We first selected CCNA2 by integrated bioinformatics analysis of four GSE databases. Next, the expression of CCNA2 in tissues and cell lines was verified by quantitative real-time PCR. The effects of CCNA2 on cell growth, proliferation, cell cycle, and apoptosis were examined by in vitro assays.ResultsWe identified 498 shared DEGs (294 upregulated and 204 downregulated), and the top ten hub genes were selected by integrated analysis. These hub genes were significantly overexpressed in CRC samples and were positively correlated. Our data revealed that the expression of CCNA2 in CRC tissues is higher than that in normal tissues. The CCNA2 knockdown could significantly suppress CRC cell growth by impairing cell cycle progression and inducing cell apoptosis.ConclusionCCNA2, as a novel oncogenic gene, plays a role in regulating cancer cell growth and apoptosis. It could be used as a new biomarker for diagnosis and therapy in CRC.

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Dual roles of yes-associated protein (YAP) in colorectal cancer

Cited by 48 publications

References 193 publications

Up-regulation of LINC00467 promotes the tumourigenesis in colorectal cancer

Up-regulation of LINC00467 promotes the tumourigenesis in colorectal cancer

Searching for the link; mechanisms underlying liver regeneration and recurrence of colorectal liver metastasis post partial hepatectomy

CCNA2 acts as a novel biomarker in regulating the growth and apoptosis of colorectal cancer

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