Dual roles of juvenile hormone signaling during early oogenesis in <i>Drosophila</i>

Luo, Wei; Veeran, Sethuraman; Wang, Jian; Li, Sheng; Li, Kang; Liu, Su-Ning

doi:10.1111/1744-7917.12698

Cited by 13 publications

(16 citation statements)

References 43 publications

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“…A recent study reported that the female GSC numbers are regulated by another important class of insect hormones, namely the juvenile hormones (JHs) ( Luo et al, 2020 ). JHs are sesquiterpenoids synthesized in the corpora allata ( Jindra et al, 2013 ; Santos et al, 2019 ; Kurogi et al, 2021 ).…”

Section: Are Insulin-like Peptides and Juvenile Hormones In Drosophila Melanogaster Involved In Mating-induced Increasmentioning

confidence: 99%

“…JH binds to two JH receptors, Methoprene-tolerant (Met) and Germ cell-expressed bHLH-PAS (Gce) ( Jindra et al, 2013 ). Double knockdown of Met and Gce in cap cells and terminal filament cells reduces the number of female GSCs ( Luo et al, 2020 ). This also validated in animals where JH biosynthetic enzyme (JH acid O -methyltransferase) is knocked down ( Luo et al, 2020 ).…”

Section: Are Insulin-like Peptides and Juvenile Hormones In Drosophila Melanogaster Involved In Mating-induced Increasmentioning

confidence: 99%

“…Double knockdown of Met and Gce in cap cells and terminal filament cells reduces the number of female GSCs ( Luo et al, 2020 ). This also validated in animals where JH biosynthetic enzyme (JH acid O -methyltransferase) is knocked down ( Luo et al, 2020 ). Notably, the synthesis of JHs in ex vivo cultured corpora allata is stimulated by synthetic SP ( Moshitzky et al, 1996 ).…”

Section: Are Insulin-like Peptides and Juvenile Hormones In Drosophila Melanogaster Involved In Mating-induced Increasmentioning

confidence: 99%

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Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit Fly Drosophila melanogaster

Hoshino

Niwa

2021

Front. Physiol.

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In many insect species, mating stimuli can lead to changes in various behavioral and physiological responses, including feeding, mating refusal, egg-laying behavior, energy demand, and organ remodeling, which are collectively known as the post-mating response. Recently, an increase in germline stem cells (GSCs) has been identified as a new post-mating response in both males and females of the fruit fly, Drosophila melanogaster. We have extensively studied mating-induced increase in female GSCs of D. melanogaster at the molecular, cellular, and systemic levels. After mating, the male seminal fluid peptide [e.g. sex peptide (SP)] is transferred to the female uterus. This is followed by binding to the sex peptide receptor (SPR), which evokes post-mating responses, including increase in number of female GSCs. Downstream of SP-SPR signaling, the following three hormones and neurotransmitters have been found to act on female GSC niche cells to regulate mating-induced increase in female GSCs: (1) neuropeptide F, a peptide hormone produced in enteroendocrine cells; (2) octopamine, a monoaminergic neurotransmitter synthesized in ovary-projecting neurons; and (3) ecdysone, a steroid hormone produced in ovarian follicular cells. These humoral factors are secreted from each organ and are received by ovarian somatic cells and regulate the strength of niche signaling in female GSCs. This review provides an overview of the latest findings on the inter-organ relationship to regulate mating-induced female GSC increase in D. melanogaster as a model. We also discuss the remaining issues that should be addressed in the future.

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Section: Are Insulin-like Peptides and Juvenile Hormones In Drosophila Melanogaster Involved In Mating-induced Increasmentioning

confidence: 99%

Section: Are Insulin-like Peptides and Juvenile Hormones In Drosophila Melanogaster Involved In Mating-induced Increasmentioning

confidence: 99%

Section: Are Insulin-like Peptides and Juvenile Hormones In Drosophila Melanogaster Involved In Mating-induced Increasmentioning

confidence: 99%

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Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit Fly Drosophila melanogaster

Hoshino

Niwa

2021

Front. Physiol.

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“…Thus, we favor a model in which expression of the key JH biosynthetic gene, jhamt and JH reporter activity within the mesoderm reflects local production and paracrine signaling ( Fig 1b,e ). Evidence for local JH activity in adult Drosophila intestines 50 and germline stem cell niches of adult Drosophila 51 has been described, with the caveat that many gonadal Gal4 drivers are also active in the nervous system 52 . Our data build on these recent findings and suggest that JH functions in a short range, paracrine manner, similar to the mammalian bioactive isoprene RA.…”

Section: Discussionmentioning

confidence: 99%

Juvenile hormones direct primordial germ cell migration to the embryonic gonad

Barton

Sanny

Dawson

et al. 2021

Preprint

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Germ cells are essential to sexual reproduction. Across the animal kingdom, extracellular isoprenoids, such as retinoic acids (RAs) in vertebrates and juvenile hormones (JHs) in insects, impact the germline lifecycle from meiosis to gametogenesis. Emerging evidence suggests that these bioactive isoprenoids also influence embryonic reproductive development, though the precise functions remain unclear. Here, we investigated the specific molecular pathways by which JHs regulates embryonic germ cell development in Drosophila. With a newly generated in vivo reporter, we find that JH signaling is active in the vicinity of germ cells as they migrate to colonize the somatic gonad. Through a combination of in vivo and in vitro assays, we find that JHs are both necessary and sufficient for primordial germ cell migration through mechanisms independent of canonical nuclear receptor-mediated transcription. These findings reveal that JH is present during Drosophila embryogenesis and that bioactive isoprenoids impact germ cell development earlier than previously appreciated. Interestingly, we find that like JH in Drosophila, RA is sufficient for murine germ cell migration in vitro, suggesting that the impact of bioactive isoprenoids on embryonic germ cell development may be broadly conserved.

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“…Other studies have suggested that JHA insecticides can affect the social activity of the honey bee and change its growth and development processes [25,26]. Genes such as cytochrome CYP6AS5 (CYP6AS5), chitinase (CHT1), cytochrome CYP15A1 (CYP15A1), and juvenile hormone acid methyltransferase (JHAMT) reportedly induce responses when insects are under JHA stress [27][28][29]. Currently, with the wider use of JHA insecticides in pest control, it is becoming increasingly important to test the toxicity of pyriproxyfen, fenoxycarb, and methoprene in honey bees as well as their regulation and molecular mechanisms.…”

Section: Introductionmentioning

confidence: 99%

The Comparison of Juvenile Hormone and Transcriptional Changes between Three Different Juvenile Hormone Analogs Insecticides on Honey Bee Worker Larval’s Development

et al. 2021

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Juvenile hormones (JHs) play a crucial role in the development of honey bee (Apis mellifera) worker larvae. Juvenile hormone analogs (JHAs), insecticides widely used in pest control, have been reported to affect the health and survival of honey bee worker larvae. However, the molecular mechanisms of JHAs in the honey bee remain unclear. In this study, we treated honey bee worker larvae with pyriproxyfen, fenoxycarb, and methoprene, three different JHAs. We monitored the changes in the transcription of genes encoding major JH response enzymes (CYP15A1, CYP6AS5, JHAMT, and CHT1) using RT-qPCR and analyzed the transcriptome changes in worker larvae under JHA stress using RNA-seq. We found that the enrichment pathways differed among the treatment groups, but the classification of each pathway was generally the same, and fenoxycarb affected more genes and more pathways than did the other two JHAs. Notably, treatment with different JHAs in the honey bee changed the JH titers in the insect to various extents. These results represent the first assessment of the effects of three different JHAs on honey bee larvae and provide a new perspective and molecular basis for the research of JH regulation and JHA toxicity in the honey bee.

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Dual roles of juvenile hormone signaling during early oogenesis in Drosophila

Cited by 13 publications

References 43 publications

Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit Fly Drosophila melanogaster

Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit Fly Drosophila melanogaster

Juvenile hormones direct primordial germ cell migration to the embryonic gonad

The Comparison of Juvenile Hormone and Transcriptional Changes between Three Different Juvenile Hormone Analogs Insecticides on Honey Bee Worker Larval’s Development

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