Dual roles and potential applications of exosomes in HCV infections

Yin, Yiqian; Zhao, Yuxue; Chen, Qiaoqiao; Chen, Yiwen; Mao, Lingxiang

doi:10.3389/fmicb.2022.1044832

Cited by 7 publications

(4 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This research shows that exosomal lncRNA-RP11-583F2.2 may be used as a biomarker for the diagnosis and prognosis of HCC. Diseases associated with HCV may be diagnosed with the use of exosomes [ 148 ].…”

Section: The Role Of Exosomes In Viral Disease Diagnosismentioning

confidence: 99%

A state-of-the-art review of the recent advances in exosome isolation and detection methods in viral infection

Gorgzadeh,

Nazari,

Ali Ehsan Ismaeel

et al. 2024

Virol J

View full text Add to dashboard Cite

Proteins, RNA, DNA, lipids, and carbohydrates are only some of the molecular components found in exosomes released by tumor cells. They play an essential role in healthy and diseased cells as messengers of short- and long-distance intercellular communication. However, since exosomes are released by every kind of cell and may be found in blood and other bodily fluids, they may one day serve as biomarkers for a wide range of disorders. In many pathological conditions, including cancer, inflammation, and infection, they play a role. It has been shown that the biogenesis of exosomes is analogous to that of viruses and that the exosomal cargo plays an essential role in the propagation, dissemination, and infection of several viruses. Bidirectional modulation of the immune response is achieved by the ability of exosomes associated with viruses to facilitate immunological escape and stimulate the body's antiviral immune response. Recently, exosomes have received a lot of interest due to their potential therapeutic use as biomarkers for viral infections such as human immunodeficiency virus (HIV), Hepatitis B virus (HBV), Hepatitis C virus (HCV), Epstein–Barr virus (EBV), and SARS-CoV-2. This article discusses the purification procedures and detection techniques for exosomes and examines the research on exosomes as a biomarker of viral infection. Graphical abstract

show abstract

Section: The Role Of Exosomes In Viral Disease Diagnosismentioning

confidence: 99%

A state-of-the-art review of the recent advances in exosome isolation and detection methods in viral infection

Gorgzadeh,

Nazari,

Ali Ehsan Ismaeel

et al. 2024

Virol J

View full text Add to dashboard Cite

show abstract

“…HCV-infected hepatocellular derived miRNAs (such as miR-122, let-7b and miR-206) as TLR7 ligands can induce macrophages to produce the B cell activating factor (BAFF) through exosomal delivery, while hepatocellular derived exosomal miR-122-induced BAFF can stimulate B cell proliferation and activation, meanwhile anti-HCV antibodies are produced during HCV infection ( Yin et al., 2022b ). Tlr3-activated macrophages impart anti-HCV activity to hepatocytes via exosomes containing members of the anti-HCV miRNA-29 family ( Zhou L. et al., 2022 ).…”

Section: The Role Of Exosomes In Virus Infectionmentioning

confidence: 99%

Research progress on the mechanism of exosome-mediated virus infection

Zhang,

Liu,

Shi

et al. 2024

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Exosomes are extracelluar vesicles that facilitate intercellular communication and are pivotal in post-transcriptional regulation within cellular gene regulatory networks, impacting pathogen dynamics. These vesicles serve as crucial regulators of immune responses, mediating cellular interactions and enabling the introduction of viral pathogenic regions into host cells. Exosomes released from virus-infected cells harbor diverse microRNAs (miRNAs), which can be transferred to recipient cells, thereby modulating virus infection. This transfer is a critical element in the molecular interplay mediated by exosomes. Additionally, the endosomal sorting complex required for transport (ESCRT) within exosomes plays a vital role in virus infection, with ESCRT components binding to viral proteins to facilitate virus budding. This review elucidates the roles of exosomes and their constituents in the invasion of host cells by viruses, aiming to shed new light on the regulation of viral transmission via exosomes.

show abstract

“…Recent studies have shown that HCV can spread by mechanisms that bypass the receptors. Therefore, the receptor-mediated therapeutic strategies (antibodies) have become less effective (Yin et al, 2022).…”

Section: Hepatitis Virus Infectionmentioning

confidence: 99%

Exosomes in viral infection: Effects for pathogenesis and treatment strategies

HEIDARI,

SEYEDEBRAHIMI,

YANG

et al. 2023

BIOCELL

View full text Add to dashboard Cite

Exosomes are small vesicles that carry molecules from one cell to another. They have many features that make them interesting for research, such as their stability, low immunogenicity, size of the nanoscale, toxicity, and selective delivery. Exosomes can also interact with viruses in diverse ways. Emerging research highlights the significant role of exosomes in viral infections, particularly in the context of diseases like COVID-19, HIV, HBV and HCV.Understanding the intricate interplay between exosomes and the human immune system holds great promise for the development of effective antiviral therapies. An important aspect is gaining clarity on how exosomes influence the immune system and enhance viral infectivity through their inherent characteristics. By leveraging the innate properties of exosomes, viruses exploit the machinery involved in exosome biogenesis to set replication, facilitate the spread of infection, and eliminate immune responses. They can either help or hinder viral infection by modulating the immune system. This review summarizes the recent findings on how exosomes mediate viral infection and how they can be used for diagnosis or therapy. This could lead to new clinical applications of exosomes in disease management.

show abstract

Dual roles and potential applications of exosomes in HCV infections

Cited by 7 publications

References 62 publications

A state-of-the-art review of the recent advances in exosome isolation and detection methods in viral infection

A state-of-the-art review of the recent advances in exosome isolation and detection methods in viral infection

Research progress on the mechanism of exosome-mediated virus infection

Exosomes in viral infection: Effects for pathogenesis and treatment strategies

Contact Info

Product

Resources

About