2019
DOI: 10.1016/j.virol.2019.07.017
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Dual role of the amphipathic helix of hepatitis C virus NS5A in the viral polyprotein cleavage and replicase assembly

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Cited by 3 publications
(7 citation statements)
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“…We recently reported that NS5A AH regulates protein-protein interactions within the replicase components ( Zhang et al., 2019a ). Mutagenesis of NS5A AH and identification of suppressor mutations in the C terminus of NS4B indicate a genetic interaction of NS5A AH with NS4B ( Biswas et al., 2016 ).…”
Section: Resultsmentioning
confidence: 99%
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“…We recently reported that NS5A AH regulates protein-protein interactions within the replicase components ( Zhang et al., 2019a ). Mutagenesis of NS5A AH and identification of suppressor mutations in the C terminus of NS4B indicate a genetic interaction of NS5A AH with NS4B ( Biswas et al., 2016 ).…”
Section: Resultsmentioning
confidence: 99%
“…Finally, we assessed the impact of the identified interactome on viral replication. We used the subgenomic replicon sgJFH1-sGluc expressing secreted Gaussia luciferase (sGluc) ( Zhang et al., 2019a ), introduced point mutations into sgJFH1-sGluc, and then assessed viral replication by monitoring the luciferase activity ( Figure 7 A). Several residues involved in the interactome have been reported to affect viral replication in previous studies ( Biswas et al., 2016 ; Elazar et al., 2004 ; Gouttenoire et al., 2014 ) ( Figure 7 B).…”
Section: Resultsmentioning
confidence: 99%
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