Dual Role of NMDAR Containing NR2A and NR2B Subunits in Alzheimer’s Disease
Iu Raïch,
Jaume Lillo,
Joan Biel Rebassa
et al.
Abstract:Alzheimer’s disease (AD) is the main cause of dementia worldwide. Given that learning and memory are impaired in this pathology, NMDA receptors (NMDARs) appear as key players in the onset and progression of the disease. NMDARs are glutamate receptors, mainly located at the post-synapse, which regulate voltage-dependent influx of calcium into the neurons. They are heterotetramers, and there are different subunits that can be part of the receptors, which are usually composed of two obligatory GluN1 subunits plus… Show more
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