Dual Role of Chondrocytes in Rheumatoid Arthritis: The Chicken and the Egg

Tseng, Chia‐Chun; Chen, Yi Jen; Chang, Wei‐An; Tsai, Wen‐Chan; Ou, Tsan‐Teng; Wu, Chuan-Chun; Sung, Wan‐Yu; Yen, Jeng‐Hsien; Kuo, Po‐Lin

doi:10.3390/ijms21031071

Cited by 36 publications

(32 citation statements)

References 120 publications

(134 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, NSAIDs have serious side effects such as stomach ulcers and do not block the synthesis of pro-inflammatory factors and proteins, which then further promote the breakdown of articular cartilage. This underlines the need for anti-inflammatory therapy, which on the one hand inhibits COX-2 (and thus prostaglandin synthesis) but on the other hand may modulate chondrocytes metabolism, further blocking progressive joint degeneration [131,132]. In fact, Subbaramaiah and co-workers demonstrated that resveratrol is a potential COX-2 inhibitor and the administration of resveratrol inhibited COX-2 expression and thus the production of PGE 2 [133].…”

Section: Resveratrolmentioning

confidence: 99%

Herbal Remedies as Potential in Cartilage Tissue Engineering: An Overview of New Therapeutic Approaches and Strategies

et al. 2020

View full text Add to dashboard Cite

It is estimated that by 2023, approximately 20% of the population of Western Europe and North America will suffer from a degenerative joint disease commonly known as osteoarthritis (OA). During the development of OA, pro-inflammatory cytokines are one of the major causes that drive the production of inflammatory mediators and thus of matrix-degrading enzymes. OA is a challenging disease for doctors due to the limitation of the joint cartilage’s capacity to repair itself. Though new treatment approaches, in particular with mesenchymal stem cells (MSCs) that integrate the tissue engineering (TE) of cartilage tissue, are promising, they are not only expensive but more often do not lead to the regeneration of joint cartilage. Therefore, there is an increasing need for novel, safe, and more effective alternatives to promote cartilage joint regeneration and TE. Indeed, naturally occurring phytochemical compounds (herbal remedies) have a great anti-inflammatory, anti-oxidant, and anabolic potential, and they have received much attention for the development of new therapeutic strategies for the treatment of inflammatory diseases, including the prevention of age-related OA and cartilage TE. This paper summarizes recent research on herbal remedies and their chondroinductive and chondroprotective effects on cartilage and progenitor cells, and it also emphasizes the possibilities that exist in this research area, especially with regard to the nutritional support of cartilage regeneration and TE, which may not benefit from non-steroidal anti-inflammatory drugs (NSAIDs).

show abstract

Section: Resveratrolmentioning

confidence: 99%

Herbal Remedies as Potential in Cartilage Tissue Engineering: An Overview of New Therapeutic Approaches and Strategies

et al. 2020

View full text Add to dashboard Cite

show abstract

“…6 b). As the sole producers of cartilaginous matrix and as mediators of inflammation, chondrocytes represent an important future cellular target for therapy in RA as well as osteoarthritis [ 44 – 46 ]. Chondrocytes have been a relatively overlooked target in fluorescence imaging approaches for RA, which have typically focused on inflammatory cells such as macrophages [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Non-invasive monitoring of arthritis treatment response via targeting of tyrosine-phosphorylated annexin A2 in chondrocytes

et al. 2021

View full text Add to dashboard Cite

Background The development and optimization of therapies for rheumatoid arthritis (RA) is currently hindered by a lack of methods for early non-invasive monitoring of treatment response. Annexin A2, an inflammation-associated protein whose presence and phosphorylation levels are upregulated in RA, represents a potential molecular target for tracking RA treatment response. Methods LS301, a near-infrared dye-peptide conjugate that selectively targets tyrosine 23-phosphorylated annexin A2 (pANXA2), was evaluated for its utility in monitoring disease progression, remission, and early response to drug treatment in mouse models of RA by fluorescence imaging. The intraarticular distribution and localization of LS301 relative to pANXA2 was determined by histological and immunohistochemical methods. Results In mouse models of spontaneous and serum transfer-induced inflammatory arthritis, intravenously administered LS301 showed selective accumulation in regions of joint pathology including paws, ankles, and knees with positive correlation between fluorescent signal and disease severity by clinical scoring. Whole-body near-infrared imaging with LS301 allowed tracking of spontaneous disease remission and the therapeutic response after dexamethasone treatment. Histological analysis showed preferential accumulation of LS301 within the chondrocytes and articular cartilage in arthritic mice, and colocalization was observed between LS301 and pANXA2 in the joint tissue. Conclusions We demonstrate that fluorescence imaging with LS301 can be used to monitor the progression, remission, and early response to drug treatment in mouse models of RA. Given the ease of detecting LS301 with portable optical imaging devices, the agent may become a useful early treatment response reporter for arthritis diagnosis and drug evaluation.

show abstract

“…An important point to note is that cartilage participates in both inflammatory and bone destruction phases (34). Chondrocytes are only resident cells in the cartilage, which not only act as target cells of inflammatory mediators, but also serve as effector cells and play an important role in cytokine cascades (15,(35)(36)(37)(38). Insights into the cascades between chondrocytes and cartilagereactive T cells could be helpful to find new biological markers and therapeutic targets of inflammatory arthritis.…”

Section: Discussionmentioning

confidence: 99%

Construction of CII-Specific CAR-T to Explore the Cytokine Cascades Between Cartilage-Reactive T Cells and Chondrocytes

et al. 2020

View full text Add to dashboard Cite

Cytokine cascades exist in many autoimmune disorders which amplify and sustain the autoimmune process and lead to chronic inflammatory injury to the host tissues. Increasing evidence indicates that chondrocytes can interact with T cells, which may be a crucial event in inflammatory arthritis. To address the reciprocal influences of cartilage-reactive T cells and chondrocytes, we constructed cartilage-reactive T cells by developing a type II collagen-specific chimeric antigen receptor (CII-CAR). An in vitro co-culture model of CII-CAR-T cells and fresh cartilage was developed, in which CII-CAR-T displayed specific proliferative capacity and cytokine release against fresh cartilage samples, and chondrocytes could respond to CII-CAR-T cells by secreting IL-6. The proposed model will help us to explore the possible cytokine cascades between cartilage-reactive T cells and cartilage.

show abstract

Dual Role of Chondrocytes in Rheumatoid Arthritis: The Chicken and the Egg

Cited by 36 publications

References 120 publications

Herbal Remedies as Potential in Cartilage Tissue Engineering: An Overview of New Therapeutic Approaches and Strategies

Herbal Remedies as Potential in Cartilage Tissue Engineering: An Overview of New Therapeutic Approaches and Strategies

Non-invasive monitoring of arthritis treatment response via targeting of tyrosine-phosphorylated annexin A2 in chondrocytes

Construction of CII-Specific CAR-T to Explore the Cytokine Cascades Between Cartilage-Reactive T Cells and Chondrocytes

Contact Info

Product

Resources

About