Dual‐Responsive Supramolecular Hydrogels from Water‐Soluble PEG‐Grafted Copolymers and Cyclodextrin

Abstract

Novel temperature and pH dual-responsive hydrogels were constructed by inclusion of poly(PEGMA)-co-poly(DMA) with alpha-cyclodextrin in aqueous solution. The temperature- or pH-induced sol/gel transition in the hydrogels was completely reversible. Studies on structure/property relationships show that chain uniformity, graft density and copolymer concentration affect the hydrogel behavior. A dual-responsive mechanism is proposed. The in vitro release of a model drug from this hydrogel was studied. It was found that the release kinetics were greatly accelerated at higher temperature and at acidic pH conditions, indicating potential applications in controlled drug delivery.

Tunable supramolecular hydrogel for in situ encapsulation and sustained release of bioactive lysozyme

“…This kind of hydrogels could be prepared in mild conditions with the advantages of easy formulation, free of any organic solvents, avoidance of chemical reactions and so on. Moreover, such hydrogels also show thixotropy property and could be used as injectable drug or cell carriers [13][14][15][16][17][18].…”

When dual and multi-responsiveness meet molecular brushes

“…Adapted from Ref. [77] with permission from Wiley. been used as a trigger to release encapsulated substances in light-responsive system, like micelles or vesicles.…”

“…In a work of Chen's, the temperature and pH dual-responsive hydrogels were constructed by molecular brushes directly [77]. The molecular brushes poly[poly(ethylene glycol) methyl ether methacrylate]-co-poly[2-(dimethylamino)ethyl methacrylate] (PPEGMA-co-PDMA) were obtained by grafting PEG chains onto the backbone of PDMA.…”

Stimuli‐Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine

“…The complexation between the host and guest molecules via non‐covalent inclusion can induce cross‐linking between the two polymer chains ( Figure 1 A). Another method includes conjugation of guest molecules onto a polymer chain which is then reacted with macrocyclic host molecules to achieve inclusion complexation (Figure B) . Finally, supramolecular hydrogels have also been developed via direct complexation of host and guest molecules after chemical modification of either host or guest or both host and guest molecules (Figure C) …”