Dual-responsive polymer-coated iron oxide nanoparticles for drug delivery and imaging applications

Sundaresan, Varsha; Menon, Jyothi U.; Rahimi, Maham; Nguyen, Kytai T.; Wadajkar, Aniket S.

doi:10.1016/j.ijpharm.2014.03.016

Cited by 76 publications

(54 citation statements)

References 43 publications

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“…5a). These results prove that the attractive force of the magnetic field on the magnetic particles that increase the particles penetration into cells [17] and [37], in combination with the slow drug release into cells above discussed, aids to an important improvement of the anticancer activity of doxorubicin. Finally, the ability of IC-SPIONs to release doxorubicin payload into HCT116 cells was confirmed by fluorescence microscopy analysis, incubating HCT116 cells with Doxo-IC-SPIONs, at drug concentration of 50 μM, both with and without the application of the external magnetic field.…”

Section: In Vitro Biological Evaluationssupporting

confidence: 55%

Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy

Scialabba

Licciardi

Mauro

et al. 2014

European Journal of Pharmaceutics and Biopharmaceutics

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This paper deal with the synthesis and characterization of PEGylated squalene-grafted-inulin amphiphile capable of self-assembling and self-organizing into nanocarriers once placed in aqueous media. It was exploited as coating agent for obtaining doxorubicin loaded superparamagnetic iron oxide nanoparticles (SPIONs) endowed with stealth like behavior and excellent physicochemical stability. Inulin was firstly modified in the side chain with primary amine groups, followed in turn by conjugation with squalenoyl derivatives through common amidic coupling agents and PEGylation by imine linkage. Polymer coated SPIONs were so obtained by spontaneous self-assembling of inulin copolymer onto magnetite surface involving hydrophobic-hydrophobic interactions between the metallic core and the squalene moieties. The system was characterized in terms of hydrodynamic radius, zeta potential, shape and drug loading capacity. On the whole, the stealth-like shell stabilized the suspension in aqueous media, though allowing the release of the doxorubicin loaded in therapeutic range. The cytotoxicity profile on cancer (HCT116) cell line and in vitro drug uptake were evaluated both with and without an external magnetic field used as targeting agent and uptake promoter, displaying that magnetic targeting implies advantageous therapeutic effects, that is amplified drug uptake and increased anticancer activity throughout the tumor mass.

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Section: In Vitro Biological Evaluationssupporting

confidence: 55%

Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy

Scialabba

Licciardi

Mauro

et al. 2014

European Journal of Pharmaceutics and Biopharmaceutics

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“…Among the polymeric NPs, the nanomaterials with stimuli-responsive structure and function have attracted impressive interest among researchers in respect of delivery of various drugs, especially anticancer agents (Bawa et al 2009;Salehi and Hamishehkar 2014;Sundaresan et al 2014). Anticancer drugs can be conjugated to pH-sensitive polymers to take the benefit of the acidic environment of tumor.…”

Section: Introductionmentioning

confidence: 99%

Preparation of thermo and pH-responsive polymer@Au/Fe3O4 core/shell nanoparticles as a carrier for delivery of anticancer agent

et al. 2015

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In this work, a thermo and pH-responsive poly-N-isopropylacrylamide-co-itaconic acid containing thiol side groups were successfully synthesized to prepare Doxorubicin-loaded polymer@Au/ Fe 3 O 4 core/shell nanoparticles (DOX-NPs). Copolymer and NPs were fully characterized by FT-IR, HNMR, photo-correlation spectroscopy, SEM, X-ray diffraction, vibrating-sample magnetometer, thermal gravimetric analysis, and UV-Vis spectroscopy. The stimuli-responsive characteristics of NPs were evaluated by in vitro release study in simulated cancerous environment. The biocompatibility and cytotoxic properties of NPs and DOX-NPs are explored by MTT method. The prepared NPs with the size of 50 nm showed paramagnetic characteristics with suitable and stable dispersion at physiological medium and high loading capacity (up to 55 %) of DOX. DOX-NPs yielded a pH-and temperaturetriggered release of entrapped drugs at tumor tissue environment (59 % of DOX release) compared to physiological condition (20 % of DOX release) during 48 h. In vitro cytotoxicity studies indicated that the NPs showed no cytotoxicity on A549 cells at different amounts after incubation for 72 h confirming its suitability as a drug carrier. DOX-NPs, on the other hand, caused an efficient anticancer performance as verified by MTT assay test. It was concluded that developed NPs by us in this study may open the possibilities for targeted delivery of DOX to the cancerous tissues.

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“…These superparamagnetic IONPs are used as contrast agents for clinical diagnostics with magnetic resonance imaging (MRI). [35][36][37] Here, we report the development of a multifunctional drug delivery system that can be tracked by MRI. This system utilizes the overexpression of LHRH-R and uPAR on PCa cells to selectively and preferentially deliver the chemotherapeutic paclitaxel (PTX) into the tumor.…”

mentioning

confidence: 99%

Double-receptor-targeting multifunctional iron oxide nanoparticles drug delivery system for the treatment and imaging of prostate cancer

Ahmed¹,

Salam²,

Yates³

et al. 2017

IJN

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As an alternative therapeutic treatment to reduce or eliminate the current side effects associated with advanced prostate cancer (PCa) chemotherapy, a multifunctional double-receptor-targeting iron oxide nanoparticles (IONPs) (luteinizing hormone-releasing hormone receptor [LHRH-R] peptide- and urokinase-type plasminogen activator receptor [uPAR] peptide-targeted iron oxide nanoparticles, LHRH-AE105-IONPs) drug delivery system was developed. Two tumor-targeting peptides guided this double-receptor-targeting nanoscale drug delivery system. These peptides targeted the LHRH-R and the uPAR on PCa cells. Dynamic light scattering showed an increase in the hydrodynamic size of the LHRH-AE105-IONPs in comparison to the non-targeted iron oxide nanoparticles (NT-IONPs). Surface analysis showed that there was a decrease in the zeta potential values for drug-loaded LHRH-AE105-IONPs compared to the NT-IONPs. Prussian blue staining demonstrated that the LHRH-AE105-IONPs were internalized efficiently by the human PCa cell line, PC-3. In vitro, magnetic resonance imaging (MRI) results confirmed the preferential binding and accumulation of LHRH-AE105-IONPs in PC-3 cells compared to normal prostate epithelial cells (RC77N/E). The results also showed that LHRH-AE105-IONPs significantly maintained T 2 MRI contrast effects and reduced T 2 values upon internalization by PC-3 cells. These paclitaxel-loaded double-receptor-targeting IONPs also showed an approximately twofold reduction in PC-3 cell viability compared to NT-IONPs.

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Dual-responsive polymer-coated iron oxide nanoparticles for drug delivery and imaging applications

Cited by 76 publications

References 43 publications

Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy

Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy

Preparation of thermo and pH-responsive polymer@Au/Fe3O4 core/shell nanoparticles as a carrier for delivery of anticancer agent

Double-receptor-targeting multifunctional iron oxide nanoparticles drug delivery system for the treatment and imaging of prostate cancer

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