Dual‐Responsive Nanogels with Cascaded Gentamicin Release and Lysosomal Escape to Combat Intracellular Small Colony Variants for Peritonitis and Sepsis Therapies
Shuang Xie,
Yu Li,
Wenxiong Cao
et al.
Abstract:Intracellular bacteria are the major cause of serious infections including sepsis and peritonitis, but face great challenges on fighting against the stubborn intracellular small colony variants (SCVs). Herein, we have developed nanogels (NGs) to destroy both planktonic bacteria and SCVs and eliminate excessive inflammations for peritonitis and sepsis therapies. Free gentamicin (GEN) and hydroxyapatite nanoparticles (NPs) with GEN loading and mannose grafts (mHAG) were inoculated into ε‐polylysine NGs to obtain… Show more
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