Dual-responsive nanocarriers from star shaped poly(<i>N</i>-isopropylacrylamide) coated mesoporous silica for drug delivery

Guo, Feng; Li, Guiying; Ma, Shenggui; Zhou, Hengquan; Yu, Xinyue

doi:10.1080/00914037.2019.1683555

Cited by 9 publications

(4 citation statements)

References 31 publications

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“…MSNs are functionalized with precise cell-targeting ligands to focus the nanosystem to the specified cells because of the presence of cell-specific receptors and reduce the systemic cytotoxic effect [ 268 ]. For instance, DOX-loaded TAT-modified MSNs [ 269 ] notably augmented intracellular and intranuclear DOX concentrations in MDR MCF-7/ADR tumor cells at a considerably increased level compared with the free DOX. TAT-peptide with YGRKKRRQRRR sequence can attach to tumor cells accessible importin and receptors, then aim at the cell nuclear pore complexes to enter the nuclei [ 270 ].…”

Section: Silica-based Nanoparticulate Drug Delivery Systemmentioning

confidence: 99%

Functionalization of Nanoparticulate Drug Delivery Systems and Its Influence in Cancer Therapy

et al. 2022

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Research into the application of nanocarriers in the delivery of cancer-fighting drugs has been a promising research area for decades. On the other hand, their cytotoxic effects on cells, low uptake efficiency, and therapeutic resistance have limited their therapeutic use. However, the urgency of pressing healthcare needs has resulted in the functionalization of nanoparticles’ (NPs) physicochemical properties to improve clinical outcomes of new, old, and repurposed drugs. This article reviews recent research on methods for targeting functionalized nanoparticles to the tumor microenvironment (TME). Additionally, the use of relevant engineering techniques for surface functionalization of nanocarriers (liposomes, dendrimers, and mesoporous silica) and their critical roles in overcoming the current limitations in cancer therapy—targeting ligands used for targeted delivery, stimuli strategies, and multifunctional nanoparticles—were all reviewed. The limitations and future perspectives of functionalized nanoparticles were also finally discussed. Using relevant keywords, published scientific literature from all credible sources was retrieved. A quick search of the literature yielded almost 400 publications. The subject matter of this review was addressed adequately using an inclusion/exclusion criterion. The content of this review provides a reasonable basis for further studies to fully exploit the potential of these nanoparticles in cancer therapy.

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Section: Silica-based Nanoparticulate Drug Delivery Systemmentioning

confidence: 99%

Functionalization of Nanoparticulate Drug Delivery Systems and Its Influence in Cancer Therapy

et al. 2022

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“…Hence, below LCST, the long chains of PNIPAM stretch because of the formation of hydrogen bonds between polymer and water, so the polymers inhibit the drug release. Above its LCST, polymers start to shrink and dehydrate, which could lead to decreasing the gap between polymer chains and shorten the release path, so the entrapped DOX could be quickly released (34). The DOX release also depends on the redox process.…”

Section: Release Studymentioning

confidence: 99%

Enzyme and Thermo Dual-stimuli Responsive DOX Carrier Based on PNIPAM Conjugated Mesoporous Silica

et al. 2022

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Background: Stimuli-responsive drug delivery systems have been proven to be a promising strategy to enhance tumor localization, overcome multidrug resistance (MDR), and reduce the side effects of chemotherapy agents. Objectives: In this study, a temperature and redox dual stimuli-responsive system using mesoporous silica nanoparticles (MSNs) for targeted delivery of doxorubicin (DOX) was developed. Methods: Mesoporous silica nanoparticles were capped with poly(N-isopropylacrylamide) (PNIPAM), a thermo-sensitive polymer, with atom transfer radical polymerization (ATRP) method, via disulfide bonds (DOX-MSN-S-S-PNIPAM) to attain a controlled system that releases DOX under glutathione-rich (GSH-rich) environments and temperatures above PNIPAM’s lower critical solution temperature (LCST). Morphological and physicochemical properties of the nanoparticles were indicated using transmission electron microscopy (TEM), dynamic light scattering (DLS), energy-dispersive X-ray spectroscopy (EDS), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and Brunauer-Emmett-Teller (BET). The drug release tests were performed at 25°C and 41°C in the absence and presence of the DTT, and the obtained results confirmed the synergic effect of temperature and reductive agent on a dual responsive release profile with a 73% cumulative release at 41°C and reductive environment during 240 min. Results: The average loaded drug content and encapsulation efficacy were reported as 42% and 29.5% at the drug: nanoparticle ratio of 1.5: 1. In vitro cytotoxicity assays on MCF-7 cell lines indicated significant viability decreased in cells exposed to DOX-MSN-S-S-PNIPAM compared to the free drug (DOX). Conclusions: Based on the results, DOX-MSN-S-S-PNIPAM has shown much more efficiency with stimuli-responsive properties in comparison to DOX on MCF-7 cancer cell lines.

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“…The LSSAs also showed good biocompatibility, sustained drug release and also enhanced cellular intake. Feng Guo and co-workers had constructed a double stimulus -sensitive nanocarriers by gathering mesoporous silica nanoparticles enhanced with 2mercaptobenzimidazole (MSN-BM) and star polymer consisting of poly(N-isopropylacrylamide) together with a E-CD nucleus (E -CD-(PNIPAM)7) [32]. The nanocarriers was formed because of host-guest interconnection between E -CD and BM.…”

Section: Multiple Stimuli Responsive CD Based Materialsmentioning

confidence: 99%

Multiple stimuli responsive cyclodextrin based smart materials for drug delivery: a review

et al. 2021

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In this review we discuss about the research advances in multiple stimuli responsive cyclodextrin (CD) based smart materials. CD based systems which are responsive to temperature, pH, enzymes, light, redox etc. along with various applications of these systems in the biomedical area are extensively covered. Current challenges and future perspectives of these smart stimuli-responsive drug delivery systems are also discussed.

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Dual-responsive nanocarriers from star shaped poly(N-isopropylacrylamide) coated mesoporous silica for drug delivery

Cited by 9 publications

References 31 publications

Functionalization of Nanoparticulate Drug Delivery Systems and Its Influence in Cancer Therapy

Functionalization of Nanoparticulate Drug Delivery Systems and Its Influence in Cancer Therapy

Enzyme and Thermo Dual-stimuli Responsive DOX Carrier Based on PNIPAM Conjugated Mesoporous Silica

Multiple stimuli responsive cyclodextrin based smart materials for drug delivery: a review

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