Dual responsive chondroitin sulfate based nanogel for antimicrobial peptide delivery

Ghaeini-Hesaroeiye, Sobhan; Boddohi, Soheil; Vasheghani‐Farahani, Ebrahim

doi:10.1016/j.ijbiomac.2019.12.026

Cited by 40 publications

(18 citation statements)

References 35 publications

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“…Smart morphological changes caused by pH or temperature allow for specific delivery ( Feng et al, 2021 ). A dual-responsive nanocarrier developed from [poly (l-lactide)-graft-chondroitin sulfate (PLLA-g-CS)] copolymer nanogels could release 25% to 98% nisin according to the changes of pH and temperature in the mimic environment of the gastrointestinal tract ( Ghaeini-Hesaroeiye et al, 2020 ).…”

Section: Organic Materials Nanosystems Containing Antimicrobial Peptidesmentioning

confidence: 99%

“…However, the disappointing antibacterial capacity of AMP-containing organic material nanosystems does not need to be of excessive concern due to the appearance of novel abilities. Many organic materials can be used to construct a targeted and controlled drug release system that adjusts the release of AMPs, increases the drug concentration at local sites ( Qi et al, 2017 ), strengthens the antimicrobial ability at specific sites ( Sun T. et al, 2018 ; Falciani et al, 2020 ; Ghaeini-Hesaroeiye et al, 2020 ; Feng et al, 2021 ), and reduces the overall drug circulation, cytotoxicity, and side effects ( Akbarzadeh et al, 2013 ; Almaaytah et al, 2017 ; Mao et al, 2017 ; Kłodzińska et al, 2019 ; Sanches et al, 2021 ). In addition, the encapsulation can act as a barrier to protect the AMPs from the recognition of the immune system, the clearance of the reticuloendothelial system, and even the degradation of proteases, ultimately improving the half-life of the AMPs in vivo ( Qi et al, 2017 ; Obuobi et al, 2019 ).…”

Section: The Impact Of Antimicrobial Properties With Nanosystems Containing Antimicrobial Peptidesmentioning

confidence: 99%

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Nanostructured Antimicrobial Peptides: Crucial Steps of Overcoming the Bottleneck for Clinics

Yang

et al. 2021

Front. Microbiol.

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The security issue of human health is faced with dispiriting threats from multidrug-resistant bacteria infections induced by the abuse and misuse of antibiotics. Over decades, the antimicrobial peptides (AMPs) hold great promise as a viable alternative to treatment with antibiotics due to their peculiar antimicrobial mechanisms of action, broad-spectrum antimicrobial activity, lower drug residue, and ease of synthesis and modification. However, they universally express a series of disadvantages that hinder their potential application in the biomedical field (e.g., low bioavailability, poor protease resistance, and high cytotoxicity) and extremely waste the abundant resources of AMP database discovered over the decades. For all these reasons, the nanostructured antimicrobial peptides (Ns-AMPs), based on a variety of nanosystem modification, have made up for the deficiencies and pushed the development of novel AMP-based antimicrobial therapies. In this review, we provide an overview of the advantages of Ns-AMPs in improving therapeutic efficacy and biological stability, reducing side effects, and gaining the effect of organic targeting and drug controlled release. Then the different material categories of Ns-AMPs are described, including inorganic material nanosystems containing AMPs, organic material nanosystems containing AMPs, and self-assembled AMPs. Additionally, this review focuses on the Ns-AMPs for the effect of biological activities, with emphasis on antimicrobial activity, biosecurity, and biological stability. The “state-of-the-art” antimicrobial modes of Ns-AMPs, including controlled release of AMPs under a specific environment or intrinsic antimicrobial properties of Ns-AMPs, are also explicated. Finally, the perspectives and conclusions of the current research in this field are also summarized.

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Section: Organic Materials Nanosystems Containing Antimicrobial Peptidesmentioning

confidence: 99%

Section: The Impact Of Antimicrobial Properties With Nanosystems Containing Antimicrobial Peptidesmentioning

confidence: 99%

Nanostructured Antimicrobial Peptides: Crucial Steps of Overcoming the Bottleneck for Clinics

Yang

et al. 2021

Front. Microbiol.

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“…Proteins and peptides show promising therapeutic potential; however, they often present limitations such as low stability, low bioavailability, and high immunogenicity [80][81][82]. Some of these issues can be solved by using hydrogels as the DDS.…”

Section: Delivery Of Peptides or Proteins Using Stimuli-responsive Hydrogelsmentioning

confidence: 99%

Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update

Pushpamalar

Meganathan

Tan

et al. 2021

Gels

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Delivering a drug to the target site with minimal-to-no off-target cytotoxicity is the major determinant for the success of disease therapy. While the therapeutic efficacy and cytotoxicity of the drug play the main roles, the use of a suitable drug delivery system (DDS) is important to protect the drug along the administration route and release it at the desired target site. Polysaccharides have been extensively studied as a biomaterial for DDS development due to their high biocompatibility. More usefully, polysaccharides can be crosslinked with various molecules such as micro/nanoparticles and hydrogels to form a modified DDS. According to IUPAC, hydrogel is defined as the structure and processing of sols, gels, networks and inorganic–organic hybrids. This 3D network which often consists of a hydrophilic polymer can drastically improve the physical and chemical properties of DDS to increase the biodegradability and bioavailability of the carrier drugs. The advancement of nanotechnology also allows the construction of hydrogel DDS with enhanced functionalities such as stimuli-responsiveness, target specificity, sustained drug release, and therapeutic efficacy. This review provides a current update on the use of hydrogel DDS derived from polysaccharide-based materials in delivering various therapeutic molecules and drugs. We also highlighted the factors that affect the efficacy of these DDS and the current challenges of developing them for clinical use.

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“…Recently, the volatility of EOs could be controlled by formulating them into different nanoformulations, including nanoemulsions, polymeric nanoparticles, nanogels, and niosomes [10,11]. Nanogels are good candidates for topical/transdermal applications; they possess many unique behaviors like fluidic nature, acquiring any shape during penetration, and modulating skin barrier for better penetration [12,13].…”

Section: Introductionmentioning

confidence: 99%

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2021

Biointerface Res Appl Chem

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Leishmaniases are a group of diseases caused by the Leishmania genus. Essential oils (EO)s have recently received more attention for the development of new green drugs. In this study, Citrus sinensis EO was used as an antileishmanial agent; its half-maximal inhibitory concentration (IC 50 ) against promastigotes of Leishmania tropica and Leishmania major was observed at 151.13 and 108.31 µg/mL. After that, the nanoemulsion-based nanogel of C. sinensis was prepared to improve its stability, potency, and facilitated topical usage. By adding carbomer 940 (2% w/v) to the prepared nanoemulsion with a 225 ± 7 nm droplet size, the nanogel was prepared. The nanogel was then impregnated on the electrospun nanofibers of chitosan-polycaprolactone, diameter = ~ 200 nm. The prototype's leishmanicidal effect was substantially better than the non-formulated EO; both species' viabilities were reduced to ~ 0%. The prepared sample could be used as a new type of dressing for cutaneous leishmaniasis; moreover, it could be considered an excellent candidate for in-vivo studies.

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Dual responsive chondroitin sulfate based nanogel for antimicrobial peptide delivery

Cited by 40 publications

References 35 publications

Nanostructured Antimicrobial Peptides: Crucial Steps of Overcoming the Bottleneck for Clinics

Nanostructured Antimicrobial Peptides: Crucial Steps of Overcoming the Bottleneck for Clinics

Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update

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