Dual renal transplant from a non-heart beating donor

Knight, Amanda J.; Ali, Ayyaz; White, Steven A.; Nicholson, Michael L.

doi:10.1111/j.1432-2277.1999.tb00776.x

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…Literature on dual‐kidney transplantation is only available for small numbers of patients with a short follow up (1 year maximum) using controlled and uncontrolled DDCA . Our recent work on single kidney transplantation from uDDCA showed that renal function is similar to that of kidneys from ECD with a better graft survival .…”

Section: Discussionmentioning

confidence: 99%

Dual kidney transplantation from uncontrolled deceased donors after cardiac arrest: A possible option

et al. 2013

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Abbreviations & Acronyms CNI = calcineurin inhibitors DDCA = deceased donor after cardiac arrest DGF = delayed graft function; DKT = dual kidney transplantation ECD = extended criteria donors eGFR = estimated glomerular filtration rate FSGS = focal and segmental glomerulosclerosis GFR = glomerular filtration rate HD = hemodialysis HLA = human leukocyte antigen MP = machine perfusion PNF = primary non function RI = resistance index SKT = single kidney transplantation TIT = total ischemic time uDDCA = uncontrolled deceased donors after cardiac arrest WIT = warm ischemic time Abstract: Organ shortage is a major problem in organ transplantation. For this reason, transplantation teams have found it necessary to revisit their organ acceptance criteria. Uncontrolled deceased donors after cardiac arrest could increase the donor pool by 20%, but at the same time there is a greater risk of delayed graft function and primary non-function. Dual kidney transplantation is an option when single kidney transplantation cannot be carried out because of lack of organ quality. We report for the first time our four first dual kidney transplantation from uncontrolled deceased donors after cardiac arrest with a follow up longer than 1 year. We described graft outcomes until 5 years, and histology at 3 and 12 months after transplantation. All organs were machine perfused in order to assess their quality leading to a single kidney transplantation or dual kidney transplantation decision. After 1 year of follow up, all grafts were functional with a mean estimated glomerular filtration rate of 44.5 ± 3.3 mL/min/1.73 m 2 , and a mean inulin clearance of 43.7 ± 13.6 mL/mn/ 1.73 m 2 . These findings suggest that dual kidney transplantation can represent a viable option for kidneys unsuitable for single kidney transplantation without increasing the rate of surgical complications. Successful transplantation is linked to histological, biological and donor clinical criteria, as well as perfusion parameters.

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Section: Discussionmentioning

confidence: 99%

Dual kidney transplantation from uncontrolled deceased donors after cardiac arrest: A possible option

et al. 2013

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“…7 Dual renal transplantation has been reported where kidneys were transplanted either bilaterally or ipsilaterally. 8,9 Most cases of dual renal transplant were performed with kidneys from cadaveric heart-beating donors. In these cases, dual transplantation was considered when organs were considered to be sub-optimal, with low creatinine clearance or having been turned down from other centres.…”

Section: Discussionmentioning

confidence: 99%

Dual ipsilateral renal transplantation from a non-heartbeating donor

Bhatti

Navarro²,

Gok³

et al. 2005

Ann R Coll Surg Engl

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A case is described where both kidneys from non-heart-beating (expanded criteria) donors were dual transplanted ipsilaterally. Although both kidneys passed viability tests on the Newcastle machine preservation system and biomarkers' evaluation, there were logistical issues where the cold ischaemic time was too protracted necessitating the transplantation of both kidneys into one recipient. The recipient had satisfactory outcome with the Cockcroft-Gault creatinine clearance of 72.47 (36.29 ml/min individual kidney glomerular filtration rate) suggesting beneficial use of sub-optimal organs to improve outcome.

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