Dual-purpose both peripheral and non-peripheral triazole substituted ZnII, MgII and PbII phthalocyanines: Synthesis, characterization, photophysicochemical and acetylcholinesterase inhibitory properties

Kanteki̇n, Hali̇t; Yalazan, Halise; Barut, Burak; Güngör, Ömer; Ünlüer, Dilek; Demirbaş, Ümit; Özel, Arzu; Durmuş, Mahmut

doi:10.1016/j.poly.2021.115416

Cited by 10 publications

(6 citation statements)

References 63 publications

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“…The effective generation of single oxygen acts as an effective photosensitizer in photodynamic cancer treatment. The nonperipheral magnesium phthalocyanine ( 72) has shown the highest inhibitory activity against AChE (IC 50 = 37.98 µM) and α-glucosidase (IC 50 = 54.05 µM) using spectrophotometric methods ( Figure 24 ) [ 113 ].…”

Section: Conjugates Of 123-triazole As Potential Ache and Buche Inhib...mentioning

confidence: 99%

An Overview of 1,2,3-triazole-Containing Hybrids and Their Potential Anticholinesterase Activities

Khan¹,

Akhtar²,

Gogoi

et al. 2023

Pharmaceuticals

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Acetylcholine (ACh) neurotransmitter of the cholinergic system in the brain is involved in learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline and acetic acid by two key cholinesterase enzymes, viz., acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). A loss or degeneration of cholinergic neurons that leads to a reduction in ACh levels is considered a significant contributing factor in the development of neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD). Numerous studies have shown that cholinesterase inhibitors can raise the level of ACh and, therefore, enhance people’s quality of life, and, at the very least, it can temporarily lessen the symptoms of NDs. 1,2,3-triazole, a five-membered heterocyclic ring, is a privileged moiety, that is, a central scaffold, and is capable of interacting with a variety of receptors and enzymes to exhibit a broad range of important biological activities. Recently, it has been clubbed with other pharmacophoric fragments/molecules in hope of obtaining potent and selective AChE and/or BuChE inhibitors. The present updated review succinctly summarizes the different synthetic strategies used to synthesize the 1,2,3-triazole moiety. It also highlights the anticholinesterase potential of various 1,2,3-triazole di/trihybrids reported in the past seven years (2015-2022), including a rationale for hybridization and with an emphasis on their structural features for the development and optimization of cholinesterase inhibitors to treat NDs.

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Section: Conjugates Of 123-triazole As Potential Ache and Buche Inhib...mentioning

confidence: 99%

An Overview of 1,2,3-triazole-Containing Hybrids and Their Potential Anticholinesterase Activities

Khan¹,

Akhtar²,

Gogoi

et al. 2023

Pharmaceuticals

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“…42 The singlet oxygen quantum yields (F D ) of the synthesized HY-ZnPc p , HY-ZnPc np , and HY-SiPc were determined by a chemical method using 1,3diphenylisobenzofuran (DPBF) as a singlet oxygen quencher in DMSO (not a toxic solvent). 37,44 The spectral changes during the determination of F D for pyrazoline-fused peripheral and non-peripheral zinc phthalocyanines (HY-ZnPc p and HY-ZnPc np ) in DMSO are given in Fig. 8.…”

Section: Photophysical Studiesmentioning

confidence: 99%

Peripherally, non-peripherally and axially pyrazoline-fused phthalocyanines: synthesis, aggregation behaviour, fluorescence, singlet oxygen generation, and photodegradation studies

2023

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“…M.p. : 237À240 C. FT Dicyano compound [56] (Q-CN) (0.3 g, 1.05 mmol) and anhydrous CoCl 2 (69 mg, 0.51 mmol) were dissolved in n-pentanol (8 ml). Then, DBU (15 drops) was dropped into the reaction mixture, and it was continued at 140 C for 1 day under inert atmosphere.…”

Section: -(5-iodopyridin-2-yloxy) Phthalonitrile (P-cn)mentioning

confidence: 99%

Investigation of photocatalytic properties of cobalt phthalocyanines on benzyl alcohol photoxidation

Yalazan

Akkol

Saka

et al. 2022

Applied Organom Chemis

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Photocatalysis is a fast and economically attractive option for oxidation reactions. Herein, 4‐(5‐iodopyridin‐2‐yloxy)phthalocyaninato cobalt(II) (P‐CoPc) and 4‐(4‐methylquinolin‐2‐yloxy)phthalocyaninato cobalt(II) (Q‐CoPc) were synthesized and characterized with spectroscopic data (FT‐IR, UV‐Vis, and mass spectra). The parameters affecting the photocatalytic activity such as substrate amount, oxidant type, substitution group, and solvent effect were studied. Both catalysts show high benzaldehyde selectivity with high TON and TOF values (470 and 1880 for P‐CoPc and 375 and 1500 for Q‐CoPc, respectively). The best photoxidation conditions were determined that 1/1500/500 (cat/subs./ox. ratio) in DMSO and in the presence of light. Aggregation and photodegradation studies of P‐CoPc and Q‐CoPc have also carried out in this work.

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Dual-purpose both peripheral and non-peripheral triazole substituted ZnII, MgII and PbII phthalocyanines: Synthesis, characterization, photophysicochemical and acetylcholinesterase inhibitory properties

Cited by 10 publications

References 63 publications

An Overview of 1,2,3-triazole-Containing Hybrids and Their Potential Anticholinesterase Activities

An Overview of 1,2,3-triazole-Containing Hybrids and Their Potential Anticholinesterase Activities

Peripherally, non-peripherally and axially pyrazoline-fused phthalocyanines: synthesis, aggregation behaviour, fluorescence, singlet oxygen generation, and photodegradation studies

Investigation of photocatalytic properties of cobalt phthalocyanines on benzyl alcohol photoxidation

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