Dual properties of pharmacological activities and preparation excipient: Bletilla striata polysaccharides

Bai, Lan; Wang, Ting; Deng, Qichuan; Zheng, Wei; Li, Xinyu; Yang, Hao; Tong, Rongsheng; Yu, Dongke; Shi, Jianyou

doi:10.1016/j.ijbiomac.2023.127643

Cited by 2 publications

(1 citation statement)

References 143 publications

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“…The UV spectrum of YCJP-1 and YCJP-2 is shown in Figure 3A,B. As suggested from the UV spectrum of YCJP-1 and YCJP-2, no significant absorptions were observed in 280 nm and 260 nm, indicating that YCJP-1 and YCJP-2 did not contain proteins and nucleic acids [14].…”

Section: Uv and Ft-ir Analysismentioning

confidence: 86%

Extraction and Isolation of Two Polysaccharides from Chloranthus japonicus Sieb. and Evaluation of Their Anti-Gastric Cancer Activities

Liu,

Li,

Jin

et al. 2024

Molecules

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Two unreported heteropolysaccharides, denoted as YCJP–1 and YCJP–2, were isolated from the herbs of Chloranthus japonicus. YCJP–1 was a heteropolysaccharide composed of glucose, galactose, arabinose, mannose, rhamnose, and a minor proportion of uronic acids, with the molecular weight mainly distributed in the 74,475–228,443 Da range. YCJP–2 was mainly composed of glucose, mannose, and galactose, with the molecular weights ranging from 848 to 5810 Da. To further evaluate the anti-gastric cancer effects of C. japonicus, the inhibitory effects of the crude polysaccharide (YCJP) and the purified polysaccharides (YCJP–1 and YCJP–2) were determined using a CCK-8 assay and colon-forming assay on MGC-803 and AGS gastric cancer cell lines. Our results showed that YCJP, YCJP–1, and YCJP–2 possess prominent inhibitory effects on the proliferation of MGC-803 and AGS cells, and the AGS cell was more sensitive to YCJP, YCJP–1, and YCJP–2. Moreover, YCJP–2 demonstrated superior anti-gastric cancer effects compared to YCJP–1. This could potentially be attributed to YCJP–2’s higher glucose content and narrower molecular weight distribution.

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Section: Uv and Ft-ir Analysismentioning

confidence: 86%

Extraction and Isolation of Two Polysaccharides from Chloranthus japonicus Sieb. and Evaluation of Their Anti-Gastric Cancer Activities

Liu,

Li,

Jin

et al. 2024

Molecules

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Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

Bao,

Zhang,

Hao

et al. 2024

Nano-Micro Lett.

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The eye, a complex organ isolated from the systemic circulation, presents significant drug delivery challenges owing to its protective mechanisms, such as the blood-retinal barrier and corneal impermeability. Conventional drug administration methods often fail to sustain therapeutic levels and may compromise patient safety and compliance. Polysaccharide-based microneedles (PSMNs) have emerged as a transformative solution for ophthalmic drug delivery. However, a comprehensive review of PSMNs in ophthalmology has not been published to date. In this review, we critically examine the synergy between polysaccharide chemistry and microneedle technology for enhancing ocular drug delivery. We provide a thorough analysis of PSMNs, summarizing the design principles, fabrication processes, and challenges addressed during fabrication, including improving patient comfort and compliance. We also describe recent advances and the performance of various PSMNs in both research and clinical scenarios. Finally, we review the current regulatory frameworks and market barriers that are relevant to the clinical and commercial advancement of PSMNs and provide a final perspective on this research area.

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Dual properties of pharmacological activities and preparation excipient: Bletilla striata polysaccharides

Cited by 2 publications

References 143 publications

Extraction and Isolation of Two Polysaccharides from Chloranthus japonicus Sieb. and Evaluation of Their Anti-Gastric Cancer Activities

Extraction and Isolation of Two Polysaccharides from Chloranthus japonicus Sieb. and Evaluation of Their Anti-Gastric Cancer Activities

Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

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