2014
DOI: 10.1002/anie.201402002
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Dual‐Pore Mesoporous Carbon@Silica Composite Core–Shell Nanospheres for Multidrug Delivery

Abstract: Monodispersed mesoporous phenolic polymer nanospheres with uniform diameters were prepared and used as the core for the further growth of core-shell mesoporous nanorattles. The hierarchical mesoporous nanospheres have a uniform diameter of 200 nm and dual-ordered mesopores of 3.1 and 5.8 nm. The hierarchical mesostructure and amphiphilicity of the hydrophobic carbon cores and hydrophilic silica shells lead to distinct benefits in multidrug combination therapy with cisplatin and paclitaxel for the treatment of … Show more

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Cited by 175 publications
(97 citation statements)
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“…as mesoporous carbon@mesoporous silica, MC@MS) for the co-delivery of hydrophilic (cisplatin) and hydrophobic (paclitaxel, Ptxl) anticancer agents [64]. A unique hollow cavity was created between the mesoporous carbon core and mesoporous silica shell (Figs 8a and b) via thermal treatment.…”
Section: Science China Materialsmentioning
confidence: 99%
“…as mesoporous carbon@mesoporous silica, MC@MS) for the co-delivery of hydrophilic (cisplatin) and hydrophobic (paclitaxel, Ptxl) anticancer agents [64]. A unique hollow cavity was created between the mesoporous carbon core and mesoporous silica shell (Figs 8a and b) via thermal treatment.…”
Section: Science China Materialsmentioning
confidence: 99%
“…Fang et al fabricated hierarchical carbon@silica core–shell nanospheres with uniform dual‐size mesopores via an in situ coating method. The obtained nanospheres exhibited a uniform size of 200 nm with hierarchical‐ordered pores of 3.1 and 5.8 nm …”
Section: Construction Of Architecturesmentioning
confidence: 99%
“…The resulting nanoparticles boast a long circulation time due to the preserved enzymatic activity and capability to still interact with its target. Hierarchal structures such as those developed by Chen et al [468] and Fang et al [469] have allowed for combinations of dual delivery featuring both hydrophobic and hydrophilic drugs, e.g. docetaxel/ irinotecan and paclitaxel/cisplatin respectively.…”
Section: Drug Deliverymentioning
confidence: 99%