Dual-photosensitizer coupled nanoscintillator capable of producing type I and type II ROS for next generation photodynamic therapy

Sengar, Prakhar; García-Tapia, Karelid; Chauhan, Kanchan; Jain, Akhil; Juárez-Moreno, Karla; Borbón-Nuñez, H.A.; Tiznado, H.; Contreras, O.; Hirata, G.A.

doi:10.1016/j.jcis.2018.10.090

Cited by 26 publications

(15 citation statements)

References 39 publications

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“…Triplet photosensitizers (TPSs) find wide applications in the area of photodynamic therapy (PDT), − photovoltaics, − photocatalytic hydrogen production (H 2 ), , and triplet–triplet annihilation upconversion. − Over the past several decades, singlet oxygen ( 1 O 2 ) has attracted the attention of not only chemists but also medical scientists. Reactive oxygen species usually produced by photosensitization play a vital role in PDT.…”

Section: Introductionmentioning

confidence: 99%

Photosensitization Ability of 1,7-Phenanthroline Based Bis−BODIPYs: Perplexing Role of Intramolecular Rotation on Photophysical Properties

Singh

Dwivedi

et al. 2019

J. Phys. Chem. C

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1,7-Phenanthroline based bis−boron dipyrromethenes (bis−BODIPYs) B1 and B2 obtained via small substitutional changes (−Cl/–SCH3) have been described. The effect of restriction of intramolecular rotation (RIR) in emission enhancement in a viscous solvent (glycerol) has been studied besides the vital role of intermolecular interactions scrutinized by X-ray single-crystal studies. The efficiency of intersystem crossing (ISC) in the generation of singlet oxygen (ΦΔ ∼ 19.2% and 56.7%) by photoirradiation using visible light along with distinct photostability has been investigated by 1,3-diphenylisobenzofuran (DPBF) titration studies. The 1O2 generation quantum yield and photosensitizing durability of the bis−BODIPYs have been investigated by photooxidation of 1,5-dihydroxynaphthalene (DHN) in the presence of B1 and B2 as photosensitizers. The pseudo-first-order rate constants for photooxidation reactions and consumption rates of DHN reflected appreciable 1O2 generation quantum yields (ΦΔ: B1, 29.0; B2, 57.8%). Density functional theory (DFT) studies showed the distribution of electron density over the dipyrrin moiety. Overall results indicated that these new photosensitizers (PSs) may be very promising in photodynamic therapy of tumors, photobiology, and organic photochemistry.

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Section: Introductionmentioning

confidence: 99%

Photosensitization Ability of 1,7-Phenanthroline Based Bis−BODIPYs: Perplexing Role of Intramolecular Rotation on Photophysical Properties

Singh

Dwivedi

et al. 2019

J. Phys. Chem. C

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“… 11 − 14 On the other hand, nanosystems consisting of both type I and type II PDT capacities were explored recently. 6 , 15 Although such nanosystems show commendable tumor ablation in vivo , practical applications are often hindered by complicated synthetic pathways and uses of UV or visible light source as the external stimuli. 16 Thus, multiple ROS nanogenerators with a straightforward synthetic paradigm have been highly sought after in the best interest of enhanced theranostics.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Carbon Dot Assembly as a Reactive Oxygen Species Nanogenerator for Ultrasound-Assisted Tumor Ablation

Jana

Wang

Rajendran

et al. 2021

JACS Au

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The efficacy of reactive oxygen species (ROS)-based therapy is substantially constrained by the limited ROS generation, stern activation conditions, and lack of a straightforward reaction paradigm. Carbon dots (CDs) have been highly sought after for therapeutic applications for their biocompatibility and intrinsic fluorescence imaging capabilities, making them suitable for ROS generation. Herein, we synthesized a CD-based ultrasmall hybrid nanostructure possessing active sites of Mo, Cu, and IR-780 dye. After cooperative self-assembly with 1,2-distearoyl- sn -glycero-3-phosphoethanolamine-poly(ethylene glycol), the obtained assembly (CMIR-CDa) exhibits near-infrared fluorescence imaging and photoacoustic tomography. Interestingly, CMIR-CDa can generate singlet oxygen ( 1 O 2 ), hydroxyl radical (·OH), and superoxide radical anion (O 2 • – ) upon ultrasound stimulus owing to its sonosensitizing and enzyme-mimicking properties, showing an enhanced efficacy for tumor ablation in vivo . The collective in vitro and in vivo results indicate that CMIR-CDa has a high potency as an ROS nanogenerator under US irradiation, even at a low concentration. The present study offers an approach for engineering hybrid CDs in a bioinspired way for intratumoral ROS augmentation in response to deep tissue penetrable external stimuli.

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“…The PDT treatment is based on controlled and localized irradiation of a photosensitizer (PS) with UV-vis light in a specific wavelength range, to result in light absorption and consequent generation of Reactive Oxygen Species (ROS) like singlet oxygen ( 1 O2), which is the most toxic ROS. 12,19,20 The photooxidation may occur by two mechanisms: (i) electron transfer between PS in excited state (PS*) and some substance in medium to form radicals and hence interact with molecular oxygen leading to ROS and (ii) the PS* transfer energy to molecular oxygen in the environment leading to a change from triplet to singlet oxygen state generating 1 O2 species 16,19 as can be seen in Fig. 1.…”

Section: Photodynamic Therapy (Pdt)mentioning

confidence: 99%

“…Wang et al reported that X-PDT displayed greater performance to kill lung cancer cell than RT in in vitro and in vivo experiments. 15 Furthermore, other studies reported benefit effects in the use of scintillating nanoparticles to combine RT and PDT as high 1 O2 yield under x-ray irradiation (6MeV, 6Gy), ROS generation in vivo or in vitro, reduction of cancers cells viability among others 12,16,19,20,28 .…”

Section: Combined Radiotherapy and Pdt (X-pdt): A New Therapy Modalitymentioning

confidence: 99%

“…14 In this context, Photodynamic Therapy (PDT) is an alternative method for cancer treatment for being a noninvasive technique allowing better control in terms of local administration of energy/drug, improving the patient's life quality and leading to successful treatment outcomes. 12,15,16 For this reason, it has been applied in several clinical treatments such as esophageal, bladder, and head and neck cancers. 17 In addition to kill cancer cell, another advantage of this therapy is the use of the light for photo stimulation, i.e., the healthy cells around some lesions are stimulated to heal due to interactions between the light and some compounds present in the cells such as lipids, proteins, and nucleic acids.…”

Section: Introductionmentioning

confidence: 99%

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Multitherapeutic nanoplatform based on Scintillating Anthracene, Silver@Antracene, and Gold@Anthracene nanoparticles for combined radiation and photodynamic therapies: enhancing radiation dose while generating, trapping, probing, or delivering singlet oxygen species

Oliveira¹

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We have synthesized anthracene and metal@anthracene core-shell nanoparticles and propose that they be used as a nanoplatform that combines radiation and photodynamic therapies. Synthesis of anthracene nanoparticles in the presence of colloidal silver or gold reduced the hydrodynamic radius in a concentration-dependent manner and caused core-shell nanostructures to grow, as revealed by AFM and DLS. Besides reduced size, the core-shell nanoparticles presented enhanced fluorescence emission.Fluorescence enhancements were higher for Ag@anthracene nanoparticles and for wavelengths approaching the plasmon resonance peak, which suggested a plasmon-enhancement phenomenon. The size-dependent enhancement in fluorescence associated with the distance between the metal core and the surface area of the nanoparticles provided an optimal core-shell diameter of 100-150 nm. We investigated singlet oxygen ( 1 O2) generation by electron spin resonance spectroscopy (ESR) with a spintrap and by fluorescence spectroscopy. The ESR/spin-trap results revealed that, in the presence of a porphyrin, anthracene nanoparticles and the core-shell nanoparticles acted as energy mediators for 1 O2 generation under exposure to light. Fluorescence suppression experiments showed that the core-shell nanoparticles captured 1 O2 at higher rates because they presented smaller size and larger surface area than anthracene nanoparticles. Together, the ESR and fluorescence results suggested that overall production of 1 O2 ( 1 O2 captured by spin-trap + 1 O2 captured by surface anthracene molecules) was higher for the core-shell nanoparticles than for anthracene nanoparticles. Moreover, because of plasmon-enhanced fluorescence and larger surface area, the Ag@anthracene nanoparticles stood out as a new and more sensitive fluorescent probe for 1 O2. During irradiation with X-rays, both anthracene and Ag@anthracene nanoparticles trapped 1 O2; subsequently, they afforded sustained release of the trapped 1 O2 for up 12 days after irradiation. This could be an interesting strategy to extend the radiation therapy treatment after the irradiation sessions. Furthermore, the presence of the metallic nanoparticle in the core of the core-shell nanostructure increased interaction with X-rays, raising the radiation dose around xii the nanoparticle. Therefore, metal@anthracene nanostructures may allow cancer treatment by different approaches depending on nanoparticle configuration.

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Dual-photosensitizer coupled nanoscintillator capable of producing type I and type II ROS for next generation photodynamic therapy

Cited by 26 publications

References 39 publications

Photosensitization Ability of 1,7-Phenanthroline Based Bis−BODIPYs: Perplexing Role of Intramolecular Rotation on Photophysical Properties

Photosensitization Ability of 1,7-Phenanthroline Based Bis−BODIPYs: Perplexing Role of Intramolecular Rotation on Photophysical Properties

Hybrid Carbon Dot Assembly as a Reactive Oxygen Species Nanogenerator for Ultrasound-Assisted Tumor Ablation

Multitherapeutic nanoplatform based on Scintillating Anthracene, Silver@Antracene, and Gold@Anthracene nanoparticles for combined radiation and photodynamic therapies: enhancing radiation dose while generating, trapping, probing, or delivering singlet oxygen species

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