Dual Photoluminescence Emission Carbon Dots for Ratiometric Fluorescent GSH Sensing and Cancer Cell Recognition

Li, Lin; Shi, Lihong; Jia, Jing; Eltayeb, Omer; Lü, Wenjing; Tang, Youhong; Dong, Chuan; Shuang, Shaomin

doi:10.1021/acsami.0c00283

Cited by 133 publications

(70 citation statements)

References 42 publications

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“…In a related study, [57] multilayered π-conjugated cores of red emissive CDs were exfoliated into single-to-few-layer CDs by microwave heating, which facilitated stronger interaction of DMF molecules with outer layers of CDs, leading to the appearance of the absorption band at 724 nm and PL band at 770 nm. Li and coworkers reported on small (2 nm) spherical CDs with dual emission at 430 and 642 nm, [98] where in presence of glutathione, the long-wavelength emission of CDs was efficiently quenched due to the glutathione-induced aggregation, but blue emission remained. It was concluded that the red emissive centers were situated nearby the CD surface.…”

Section: Steady-state Photoluminescencementioning

confidence: 99%

Optical Properties of Carbon Dots in the Deep‐Red to Near‐Infrared Region Are Attractive for Biomedical Applications

Ushakova

Rogach

et al. 2021

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101

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range (NIR-I region: 700-900 nm; NIR-II region: 1000-1700 nm). [15][16][17][18][19][20] Deep tissue penetration can be realized in this spectral range owing to the low degree level of photon absorption, scattering, and autofluorescence from tissues. [21,22] Therefore, imaging and therapeutic agents which operate in the DR to NIR region are highly desired. For CDs, strong PL in the blue and green region has been reported on numerous occasions, with PL quantum yields (QY) up to 90%, [23,24] while CDs with efficient longer wavelength emission have experienced extensive development only recently. Starting from the first report on the orange emissive CDs (PL peak at 580 nm) with a PL QY of 46%, [25] red emissive CDs with PL peak at 628 nm and PL QY of 53%, [26] and NIR emissive CDs with PL peak at 715 nm and PL QY of 43% [27] were introduced. A number of strategies, such as enlarging the π-conjugated structure, enhancing the surface oxidation, and employing proper precursors such as phenylenediamines were proved as effective for realization of such CDs. This review starts from summary of synthetic strategies toward CDs with absorption/PL at the wavelength from 650 nm and into the NIR-I and NIR-II spectral region. We then consider in detail the Stokes and anti-Stokes PL (ASPL), chemiluminescence (CL) and formation of reactive oxygen species (ROS) for the DR/NIR CDs. At the end, we provide a concise summary of already reported biomedical applications of CDs, such as in the photoacoustic (PA) imaging and photothermal therapy (PTT), photodynamic therapy (PDT), and their use as bioimaging agents and drug carriers.Carbon dots (CDs) represent a recently emerged class of luminescent materials with a great potential for biomedical theranostics, and there are a lot of efforts to shift their absorption and emission toward deep-red (DR) to near-infrared (NIR) region falling in the biological transparency window. This review offers comprehensive insights into the synthesis strategies aimed to achieve this goal, and the current approaches of modulating the optical properties of CDs over the DR to NIR region. The underlying mechanisms of their absorption, photoluminescence, and chemiluminescence, as well as the related photophysical processes of photothermal conversion and formation of reactive oxygen species are considered. The already available biomedical applications of CDs, such as in the photoacoustic imaging and photothermal therapy, photodynamic therapy, and their use as bioimaging agents and drug carriers are then shortly summarized.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/smll.202102325. Figure 12. a) In vivo NIR fluorescence images of a mouse stomach before (left) and after (right) gavage injection of CDs in PVP aqueous solution.Reproduced with permission. [46] Copyright 2018, Wiley-VCH. b) NIR fluorescence images of mouse tumor after intravenous injection of CDs at various time points. c) NIR fluorescence of H22 tumors that were dissected from mice at ...

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Section: Steady-state Photoluminescencementioning

confidence: 99%

Optical Properties of Carbon Dots in the Deep‐Red to Near‐Infrared Region Are Attractive for Biomedical Applications

Ushakova

Rogach

et al. 2021

Small

110

101

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“…And the two peaks at 531.5 and 532.7 eV in the high-resolution O1s spectrum (Fig. 2C) belonged to the C=O/C-OH, and C-O-C groups, 21,22 respectively. The N1s band can be divided into three peaks at 399.8, 400.6, and 401.5 eV, which indicates the existence of C=N, C-N, and -NH2 groups, 19,20 respectively.…”

Section: Characterization and Optical Properties Of The Nfncbsmentioning

confidence: 96%

On-off Fluorescent Switching of Excitation-independent Near-ultraviolet Emission Carbon Nanobelts for Ultrasensitive Detection Nimesulide in Pharmaceutical Tablet

et al. 2020

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Here, we present an excellent strategy of unmodified near-ultraviolet fluorescence nitrogen doping carbon nanobelts (NFNCBs) for detecting nimesulide (Nim). After a simple hydrothermal process of uric acid and hydroquinone in DMF solvent, NFNCBs shows the shape of corroded stalactite-like composed of nanobelts aggregates, near-ultraviolet luminescence and a narrowed full width at half maximum. This could improve/change the electronic properties and surface chemical active site, as the result of a sensitive response to Nim. By employing this sensor, the quantitative measurement displays a linear range of 2.0 nM-100.0 μM with a lower detection limit of 0.21 nM (3σ/k) for Nim. Our work has provided a high selectivity for Nim, which may be capable for pharmaceutical sample analysis in real tablets. Furthermore, the results concerning the recoveries (96.3-106.2%) for real sample analysis indicate that this nanoprobe might expand a good avenue to design an effective luminescence nanoprobe for other biologically related drugs.

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“…Cancer has become an emerging health issue in the world. [1][2][3][4] Recently, imaging-guided stimuli-responsive nanoscale drug delivery system for cancer therapy has attracted considerable attention and become one of the research hotspots in targeted cancer therapy. [5][6][7][8][9] In general, ideal multifunctional drug delivery system for targeted therapy of cancer through intravenous administration will rstly circulate in the blood, then accumulate at tumor sites and nally release the drugs aer internalization into cancer cells.…”

Section: Introductionmentioning

confidence: 99%

pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

Zhang

Duan

et al. 2021

RSC Adv.

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Dual Photoluminescence Emission Carbon Dots for Ratiometric Fluorescent GSH Sensing and Cancer Cell Recognition

Cited by 133 publications

References 42 publications

Optical Properties of Carbon Dots in the Deep‐Red to Near‐Infrared Region Are Attractive for Biomedical Applications

Optical Properties of Carbon Dots in the Deep‐Red to Near‐Infrared Region Are Attractive for Biomedical Applications

On-off Fluorescent Switching of Excitation-independent Near-ultraviolet Emission Carbon Nanobelts for Ultrasensitive Detection Nimesulide in Pharmaceutical Tablet

pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

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