Dual phenotypic characteristics of P-selectin in a mouse model of hemorrhagic shock and hepatectomy

Chen, Jen-Lung; Cheng, Tzu-Ting; Huang, Chien-Chi; Chang, Hsin-Hou; Lam, Chen-Fuh

doi:10.1016/j.heliyon.2023.e18627

Cited by 1 publication

(1 citation statement)

References 26 publications

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“…Male wild-type C57BL/6J mice aged 8–12 weeks were purchased from the National Laboratory Animal Center (Taipei, Taiwan) [ 14 , 15 , 16 , 17 ]. Genetically deficient Selp −/− (B6; 129S2- Selp tm1Hyn /J; P-selectin KO) [ 47 , 77 , 78 , 79 ] with a C57BL/6J background were obtained from the Jackson Laboratory (Bar Harbor, ME, USA). Selp −/− mice were backcrossed with WT C57Bl/6J mice over six generations.…”

Section: Methodsmentioning

confidence: 99%

Restraint Stress-Induced Immunosuppression Is Associated with Concurrent Macrophage Pyroptosis Cell Death in Mice

Li,

Munalisa,

Lee

et al. 2023

IJMS

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Psychological stress is widely acknowledged as a major contributor to immunosuppression, rendering individuals more susceptible to various diseases. The complex interplay between the nervous, endocrine, and immune systems underlies stress-induced immunosuppression. However, the underlying mechanisms of psychological-stress-induced immunosuppression remain unclear. In this study, we utilized a restraint stress mouse model known for its suitability in investigating physiological regulations during psychological stress. Comparing it with cold exposure, we observed markedly elevated levels of stress hormones corticosterone and cortisol in the plasma of mice subjected to restraint stress. Furthermore, restraint-stress-induced immunosuppression differed from the intravenous immunoglobulin-like immunosuppression observed in cold exposure, with restraint stress leading to increased macrophage cell death in the spleen. Suppression of pyroptosis through treatments of inflammasome inhibitors markedly ameliorated restraint-stress-induced spleen infiltration and pyroptosis cell death of macrophages in mice. These findings suggest that the macrophage pyroptosis associated with restraint stress may contribute to its immunosuppressive effects. These insights have implications for the development of treatments targeting stress-induced immunosuppression, emphasizing the need for further investigation into the underlying mechanisms.

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