Dual‐Phase Thermally Activated Delayed Fluorescence Luminogens: A Material for Time‐Resolved Imaging Independent of Probe Pretreatment and Probe Concentration

Li, Xuping; Baryshnikov, Gleb V.; Ding, Lei; Bao, Xiaoyan; Li, Xin; Lu, Jianjun; Liu, Miaoqing; Shen, Shen; Luo, Mengkai; Zhang, Man; Ågren, Hans; Wang, Xudong; Zhu, Liangliang

doi:10.1002/anie.202000185

Cited by 46 publications

(34 citation statements)

References 48 publications

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“…In recent years, fabrication of diverse TADF nanoplatforms has emerged as the most robust methodology for employing the TADF luminophores. [14,16,24,27,41,68,82,83] In this way, the rotational and vibrational degrees of freedom in TADF molecules could be suppressed when encapsulated within NPs, resulting in enhancing their luminescence performance in biomedical research. [42] As depicted in Figure 6, four representative strategies have been developed to prepare TADF nanomaterials in biomedicine.…”

Section: Design Strategies Of Tadf Nanomaterialsmentioning

confidence: 99%

Thermally Activated Delayed Fluorescence Material: An Emerging Class of Metal‐Free Luminophores for Biomedical Applications

et al. 2021

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The development of simple, efficient, and biocompatible organic luminescent molecules is of great significance to the clinical transformation of biomaterials. In recent years, purely organic thermally activated delayed fluorescence (TADF) materials with an extremely small single-triplet energy gap (𝚫E ST ) have been considered as the most promising new-generation electroluminescence emitters, which is an enormous breakthrough in organic optoelectronics. By merits of the unique photophysical properties, high structure flexibility, and reduced health risks, such metal-free TADF luminophores have attracted tremendous attention in biomedical fields, including conventional fluorescence imaging, time-resolved imaging and sensing, and photodynamic therapy. However, there is currently no systematic summary of the TADF materials for biomedical applications, which is presented in this review. Besides a brief introduction of the major developments of TADF material, the typical TADF mechanisms and fundamental principles on design strategies of TADF molecules and nanomaterials are subsequently described. Importantly, a specific emphasis is placed on the discussion of TADF materials for various biomedical applications. Finally, the authors make a forecast of the remaining challenges and future developments. This review provides insightful perspectives and clear prospects towards the rapid development of TADF materials in biomedicine, which will be highly valuable to exploit new luminescent materials.

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Section: Design Strategies Of Tadf Nanomaterialsmentioning

confidence: 99%

Thermally Activated Delayed Fluorescence Material: An Emerging Class of Metal‐Free Luminophores for Biomedical Applications

et al. 2021

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“…Accordingly, a change of the luminescence properties upon aggregation can be used for visualizing material aggregation and self-assembly with different forms. Aggregation-induced emission (AIE) [ 4 – 11 ], referring to some type of organic luminophores that can reveal bright luminescence in aggregated or solid states by the suppression of the nonradiative decay, plays an important role in many fields of application, like displays and lighting [ 4 – 11 ], in information technology [ 12 – 15 ], and molecular probing [ 16 – 18 ]. However, water is largely required for the preparation of AIE aggregates ( e.g.…”

Section: Introductionmentioning

confidence: 99%

Visualizing Material Processing via Photoexcitation-Controlled Organic-Phase Aggregation-Induced Emission

Yue

Baryshnikov

et al. 2021

Research

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Aggregation-induced emission (AIE) has been much employed for visualizing material aggregation and self-assembly. However, water is generally required for the preparation of the AIE aggregates, the operation of which limits numerous material processing behaviors. Employing hexathiobenzene-based small molecules, monopolymers, and block copolymers as different material prototypes, we herein achieve AIE in pure organic phases by applying a nonequilibrium strategy, photoexcitation-controlled aggregation. This strategy enabled a dynamic change of molecular conformation rather than chemical structure upon irradiation, leading to a continuous aggregation-dependent luminescent enhancement (up to ~200-fold increase of the luminescent quantum yield) in organic solvents. Accompanied by the materialization of the nonequilibrium strategy, photoconvertible self-assemblies with a steady-state characteristic can be achieved upon organic solvent processing. The visual monitoring with the luminescence change covered the whole solution-to-film transition, as well as the in situ photoprocessing of the solid-state materials.

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“…To produce such as ingle-luminophore dual TADF,o ne needs to employ the first excited states (S 1 and T 1 )and higher excited states (i.e., the anti-Kashasrule emission pathways, [13] S 2 and T 2 )f or emission. Inspired by molecules with TADF emission at either short or long wavelengths, [14] we present adesign of unsymmetrical donor/acceptor alternate (D-A-D') molecular structure (M-1, Figure 1), which can exert two independent electronic transitions from the phenothiazine (D) and N-(1h-indole-5-yl) acetamide (D')d onors to the diphenylsulfone acceptor (A). Compared with the relevant TADF strategy originating from the transition of local excited triplet ( 3 LE) and charge-transfer triplet ( 3 CT) to chargetransfer singlet ( 1 CT), [15] this single-luminophore dual TADF can perform aw ider spectral wavelength distribution to satisfy the above-mentioned hypothesis.…”

Section: Introductionmentioning

confidence: 99%

Integrating Time‐Resolved Imaging Information by Single‐Luminophore Dual Thermally Activated Delayed Fluorescence

Luo

Ding

et al. 2020

Angewandte Chemie

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The fact that the lifetime of photoluminescence is often difficult to access because of the weakness of the emission signals, seriously limits the possibility to gain local bioimaging information in time‐resolved luminescence probing. We aim to provide a solution to this problem by creating a general photophysical strategy based on the use of molecular probes designed for single‐luminophore dual thermally activated delayed fluorescence (TADF). The structural and conformational design makes the dual TADF strong in both diluted solution and in an aggregated state, thereby reducing sensitivity to oxygen quenching and enabling a unique dual‐channel time‐resolved imaging capability. As the two TADF signals show mutual complementarity during probing, a dual‐channel means that lifetime mapping is established to reduce the time‐resolved imaging distortion by 30–40 %. Consequently, the leading intracellular local imaging information is serialized and integrated, which allows comparison to any single time‐resolved signal, and leads to a significant improvement of the probing capacity.

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Dual‐Phase Thermally Activated Delayed Fluorescence Luminogens: A Material for Time‐Resolved Imaging Independent of Probe Pretreatment and Probe Concentration

Cited by 46 publications

References 48 publications

Thermally Activated Delayed Fluorescence Material: An Emerging Class of Metal‐Free Luminophores for Biomedical Applications

Thermally Activated Delayed Fluorescence Material: An Emerging Class of Metal‐Free Luminophores for Biomedical Applications

Visualizing Material Processing via Photoexcitation-Controlled Organic-Phase Aggregation-Induced Emission

Integrating Time‐Resolved Imaging Information by Single‐Luminophore Dual Thermally Activated Delayed Fluorescence

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