Dual pH-/thermo-responsive chitosan-based hydrogels prepared using "click" chemistry for colon-targeted drug delivery applications

Hoang, Huong Thi; Jo, Sung‐Han; Phan, Quoc-Thang; Park, Hansol; Park, Sang-Hyug; Oh, Chul‐Woong; Lim, Kwon Taek

doi:10.1016/j.carbpol.2021.117812

Cited by 75 publications

(28 citation statements)

References 51 publications

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“…The results showed the hydrogel swelling and an almost complete drug release (92%) at the intestinal environment of pH 7.4 and 37 °C, whereas these activities were inhibited for an acid environment of pH 2.2. The obtained hydrogel exhibits stimuli-responsive properties that make it an excellent material for colon-targeted controlled drug release [ 192 ].…”

Section: Applications Of Smart Hydrogelsmentioning

confidence: 99%

Hydrogels Classification According to the Physical or Chemical Interactions and as Stimuli-Sensitive Materials

Bustamante-Torres

Romero-Fierro

Arcentales-Vera

et al. 2021

Gels

148

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Hydrogels are attractive biomaterials with favorable characteristics due to their water uptake capacity. However, hydrogel properties are determined by the cross-linking degree and nature, the tacticity, and the crystallinity of the polymer. These biomaterials can be sorted out according to the internal structure and by their response to external factors. In this case, the internal interaction can be reversible when the internal chains are led by physicochemical interactions. These physical hydrogels can be synthesized through several techniques such as crystallization, amphiphilic copolymers, charge interactions, hydrogen bonds, stereo-complexing, and protein interactions. In contrast, the internal interaction can be irreversible through covalent cross-linking. Synthesized hydrogels by chemical interactions present a high cross-linking density and are employed using graft copolymerization, reactive functional groups, and enzymatic methods. Moreover, specific smart hydrogels have also been denoted by their external response, pH, temperature, electric, light, and enzyme. This review deeply details the type of hydrogel, either the internal structure or the external response. Furthermore, we detail some of the main applications of these hydrogels in the biomedicine field, such as drug delivery systems, scaffolds for tissue engineering, actuators, biosensors, and many other applications.

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Section: Applications Of Smart Hydrogelsmentioning

confidence: 99%

Hydrogels Classification According to the Physical or Chemical Interactions and as Stimuli-Sensitive Materials

Bustamante-Torres

Romero-Fierro

Arcentales-Vera

et al. 2021

Gels

148

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“…The fabrication of in situ hydrogels using the chemical crosslinking method enhances the mechanical properties of hydrogels. This method utilizes chemical crosslinkers (e.g., genipin, formaldehyde, glutaraldehyde, and epoxy compounds) to react with crosslinkable functional groups of the polysaccharides [28,29]. For instance, the primary amino groups (-NH 2 ) of chitosan and gelatin were co-crosslinked by β-glycerophosphate and genipin forming in situ hydrogels for intraocular drug delivery [29].…”

Section: In Situ-forming Hydrogelsmentioning

confidence: 99%

“…For instance, the primary amino groups (-NH 2 ) of chitosan and gelatin were co-crosslinked by β-glycerophosphate and genipin forming in situ hydrogels for intraocular drug delivery [29]. Recently, 'click' reactions such as Diels-Alder and thiol-ene reactions showed promising potential to produce in situ-forming hydrogels under mild preparative conditions [28,30].…”

Section: In Situ-forming Hydrogelsmentioning

confidence: 99%

Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update

Pushpamalar

Meganathan

Tan

et al. 2021

Gels

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Delivering a drug to the target site with minimal-to-no off-target cytotoxicity is the major determinant for the success of disease therapy. While the therapeutic efficacy and cytotoxicity of the drug play the main roles, the use of a suitable drug delivery system (DDS) is important to protect the drug along the administration route and release it at the desired target site. Polysaccharides have been extensively studied as a biomaterial for DDS development due to their high biocompatibility. More usefully, polysaccharides can be crosslinked with various molecules such as micro/nanoparticles and hydrogels to form a modified DDS. According to IUPAC, hydrogel is defined as the structure and processing of sols, gels, networks and inorganic–organic hybrids. This 3D network which often consists of a hydrophilic polymer can drastically improve the physical and chemical properties of DDS to increase the biodegradability and bioavailability of the carrier drugs. The advancement of nanotechnology also allows the construction of hydrogel DDS with enhanced functionalities such as stimuli-responsiveness, target specificity, sustained drug release, and therapeutic efficacy. This review provides a current update on the use of hydrogel DDS derived from polysaccharide-based materials in delivering various therapeutic molecules and drugs. We also highlighted the factors that affect the efficacy of these DDS and the current challenges of developing them for clinical use.

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“…Elsayed et al reported the preparation of CS-based membranes through the coupling of CS with activated trans -3-(4-pyridyl) acrylic acid, followed by covalent cross-linking of the pyridyl moieties via UV light promoted [2+2] cycloaddition [ 34 ]. Similarly, the conjugation of CS amines to activated 5-norbornene-2-carboxylic acid allowed for subsequent inverse electron-demand Diels Alder cycloaddition in the presence of a bis-tetrazine-containing cross-linker to afford hydrogels with increased pore size [ 35 ]. This system demonstrated enhanced capacity for the loading and further release of 5-aminosalicylic acid, in comparison with the reference glutaraldehyde (Glu) cross-linked CS hydrogels.…”

Section: Strategies For Covalent Functionalizationmentioning

confidence: 99%

“…The water signal is commonly used as reference peak, and its position was reported in the range 4.5–6.0 ppm depending on the solvent mixture used. Moreover, 1 H NMR is the most common way to determine the DD of CS [ 17 , 85 ] as well as the GD of small molecules [ 35 , 77 ] or polymers [ 32 , 39 ] grafted on CS.…”

Section: Characterization Of Cs-based Materialsmentioning

confidence: 99%

Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

2021

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Chitosan (CS) is a natural biopolymer that has gained great interest in many research fields due to its promising biocompatibility, biodegradability, and favorable mechanical properties. The versatility of this low-cost polymer allows for a variety of chemical modifications via covalent conjugation and non-covalent interactions, which are designed to further improve the properties of interest. This review aims at presenting the broad range of functionalization strategies reported over the last five years to reflect the state-of-the art of CS derivatization. We start by describing covalent modifications performed on the CS backbone, followed by non-covalent CS modifications involving small molecules, proteins, and metal adjuvants. An overview of CS-based systems involving both covalent and electrostatic modification patterns is then presented. Finally, a special focus will be given on the characterization techniques commonly used to qualify the composition and physical properties of CS derivatives.

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Dual pH-/thermo-responsive chitosan-based hydrogels prepared using "click" chemistry for colon-targeted drug delivery applications

Cited by 75 publications

References 51 publications

Hydrogels Classification According to the Physical or Chemical Interactions and as Stimuli-Sensitive Materials

Hydrogels Classification According to the Physical or Chemical Interactions and as Stimuli-Sensitive Materials

Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update

Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

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