Dual pH/reduction-responsive hybrid polymeric micelles for targeted chemo-photothermal combination therapy

Zhang, Linhua; Qin, Yu; Zhang, Zhiming; Fan, Fan; Huang, Chenlu; Lü, Li; Wang, Hai; Jin, Xiaona; Zhao, Huanying; Kong, Deling; Wang, Chun; Sun, Hongfan; Leng, Xigang; Zhu, Dunwan

doi:10.1016/j.actbio.2018.05.026

Cited by 68 publications

(29 citation statements)

References 57 publications

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“…One reason is insufficient drug release that involves a high local accumulation of DDSs that cannot convert into effective drug levels in the target sites. This calls for a new and effective approach that improves drug release in cancer cells in response to certain continuous stimuli . In addition, the poor tumor penetration of DDSs is another cause for their disappointing therapeutic efficacy.…”

Section: Introductionmentioning

confidence: 99%

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

Liu

Wang

et al. 2019

Adv Healthcare Materials

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Tumor growth and metastasis are the major causes of high mortality in breast cancer. In this study, a water‐responsive phospholipid‐calcium‐carbonate hybrid nanoparticle (PL/ACC‐DOX&ICG) surface modified with a phospholipid shell is designed and covered with a shielding polymer polyethylene glycol; this development is loaded with the photosensitizer indocyanine green (ICG) and the chemotherapeutic drug doxorubicin (DOX) for near‐infrared (NIR) imaging and chemophotothermal combination therapy against breast cancer. PL/ACC‐DOX&ICG exhibits satisfactory stability against various aqueous environments with minimal drug leakage and can readily decompose to facilitate quick drug release into cancer cells. In vivo biodistribution studies, PL/ACC‐DOX&ICG demonstrated strong tumor‐homing properties. Interestingly, the in vitro cellular uptake and intratumoral penetration depth of PL/ACC‐DOX&ICG are significantly enhanced under NIR laser irradiation, owing to ICG‐induced hyperthermia, which not only enhances cell permeability and fluidity but also disrupts the dense tumor extracellular matrix. Compared to chemotherapy or photothermal therapy alone, chemophotothermal combination therapy synergistically induces apoptosis and death in 4T1 cells. Moreover, compared with the phosphate buffer saline group, the combined treatment suppress primary tumor growth at a rate of approximately 94.88% and decrease the number of metastatic nodules by about 93.6%. Therefore, PL/ACC‐DOX&ICG may be a promising nanoplatform for breast cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

Liu

Wang

et al. 2019

Adv Healthcare Materials

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“…These stimuli may be endogenous or exogenous or a combination of both. For instance, Zhang et al [95] reported pH and redox (dual endogenous stimuli) responsive micelles for tumor targeting. They synthesized copolymers based on poly(ε-caprolactone) (PCL) and poly(ethylene glycol) (PEG) by disulfide (PCL-ss-PEG-ss-PCL) and acetal (PCL-acetal-PEG) linkages and their mixture was used to fabricate dual responsive micelles.…”

Section: Dual/multi-responsive Ddsmentioning

confidence: 99%

Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release

et al. 2019

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In this study, we reviewed state-of-the-art endogenous-based and exogenous-based stimuli-responsive drug delivery systems (DDS) for programmed site-specific release to overcome the drawbacks of conventional therapeutic modalities. This particular work focuses on the smart chemistry and mechanism of action aspects of several types of stimuli-responsive polymeric carriers that play a crucial role in extracellular and intracellular sections of diseased tissues or cells. With ever increasing scientific knowledge and awareness, research is underway around the globe to design new types of stimuli (external/internal) responsive polymeric carriers for biotechnological applications at large and biomedical and/or pharmaceutical applications, in particular. Both external/internal and even dual/multi-responsive behavior of polymeric carriers is considered an essential element of engineering so-called ‘smart’ DDS, which controls the effective and efficient dose loading, sustained release, individual variability, and targeted permeability in a sophisticated manner. So far, an array of DDS has been proposed, developed, and implemented. For instance, redox, pH, temperature, photo/light, magnetic, ultrasound, and electrical responsive DDS and/or all in all dual/dual/multi-responsive DDS (combination or two or more from any of the above). Despite the massive advancement in DDS arena, there are still many challenging concerns that remain to be addressed to cover the research gap. In this context, herein, an effort has been made to highlight those concerning issues to cover up the literature gap. Thus, the emphasis was given to the drug release mechanism and applications of endogenous and exogenous based stimuli-responsive DDS in the clinical settings.

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“…Mice were sacrificed at 24 h post-injection and major organs (heart, liver, spleen, lung, kidney, and tumor) harvested for ex vivo imaging and semi-quantitative biodistribution analysis. [23][24][25]…”

Section: In Vivo Biodistribution Analysismentioning

confidence: 99%

<p>Doxorubicin Delivered Using Nanoparticles Camouflaged with Mesenchymal Stem Cell Membranes to Treat Colon Cancer</p>

Liu

Zhao

Jiang

et al. 2020

IJN

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Purpose: The primary goal of the present study was to design doxorubicin (DOX)-loaded superparamagnetic iron oxide (SPIO) nanoparticles (NPs) coated with mesenchymal stem cell (MSC) membranes and explore their effect on colon cancer in vitro and in vivo. Methods: DOX-SPIO NPs were coated with MSC membranes using an extruder, and the morphological characteristics of MSC membrane-camouflaged nanodrug (DOX-SPIO@MSCs) evaluated by transmission electron microscopy (TEM) and NP-tracking analysis. Drug loading and pH response were assessed by UV spectrophotometry. Intracellular colocalization was analyzed using NP-treated MC38 cells stained with 3,3′-dioctadecyloxacarbocyanine perchlorate and Hoechst 33342. Cellular uptake was analyzed using an inverted fluorescence microscope and flow cytometry and cytotoxicity evaluated by cell counting kit-8 assay. Biological compatibility was assessed by hemolysis analysis, immunoactivation test and leukocyte uptake experiments. Furthermore, intravenous injection of chemotherapy drugs into MC38 tumor-bearing C57BL/6 mice was used to study anti-tumor effects. Results: Typical core-shell NP structures were observed by TEM. Particle size remained stable in fetal bovine serum and phosphate-buffered saline (PBS). Compared with DOX-SPIO, DOX-SPIO@MSCs improved cellular uptake efficiency, enhanced anti-tumor effects, and reduced the immune system response. Animal experiments demonstrated that DOX-SPIO@MSCs enhanced tumor treatment efficacy while reducing systemic side effects. Conclusion: Our experimental results demonstrate that DOX-SPIO@MSCs are a promising targeted nanocarrier for application in treatment of colon cancer.

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Dual pH/reduction-responsive hybrid polymeric micelles for targeted chemo-photothermal combination therapy

Cited by 68 publications

References 57 publications

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release

<p>Doxorubicin Delivered Using Nanoparticles Camouflaged with Mesenchymal Stem Cell Membranes to Treat Colon Cancer</p>

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