Dual Oxidase 2 (DUOX2) as a Proteomic Biomarker for Predicting Treatment Response to Chemoradiation Therapy for Locally Advanced Rectal Cancer: Using High-Throughput Proteomic Analysis and Machine Learning Algorithm
Abstract:High-throughput mass-spectrometry-based quantitative proteomic analysis was performed using formalin-fixed, paraffin-embedded (FFPE) biopsy samples obtained before treatment from 13 patients with locally advanced rectal cancer (LARC), who were treated with concurrent chemoradiation therapy (CCRT) followed by surgery. Patients were divided into complete responder (CR) and non-complete responder (nCR) groups. Immunohistochemical (IHC) staining of 79 independent FFPE tissue samples was performed to validate the p… Show more
Considering the success of our previous Special Issue (SI) “Proteomics and Its Applications in Cancers”, we aimed to attract more publications where cancer proteomics is involved [...]
Considering the success of our previous Special Issue (SI) “Proteomics and Its Applications in Cancers”, we aimed to attract more publications where cancer proteomics is involved [...]
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