Dual-Omics Approach Unveils Novel Perspective on the Quality Control of Genetically Engineered Exosomes
Christopher Olson,
Konstantin Ivanov,
Darin Boyes
et al.
Abstract:Exosomes, nanoscale vesicles derived from human cells, offer great promise for targeted drug delivery. However, their inherent diversity and genetic modifications present challenges in terms of ensuring quality in clinical use. To explore solutions, we employed advanced gene fusion and transfection techniques in human 293T cells to generate two distinct sets of genetically engineered samples. We used dual-omics analysis, combining transcriptomics and proteomics, to comprehensively assess exosome quality by com… Show more
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