Dual neutrophil subsets exacerbate or suppress inflammation in tuberculosis via IL-1β or PD-L1
Emilie Doz-Deblauwe,
Badreddine Bounab,
Florence Carreras
et al.
Abstract:Neutrophils can be beneficial or deleterious during tuberculosis (TB). Based on the expression of MHC-II and programmed death ligand 1 (PD-L1), we distinguished two functionally and transcriptionally distinct neutrophil subsets in the lungs of mice infected with mycobacteria. Inflammatory [MHC-II−, PD-L1lo] neutrophils produced inflammasome-dependent IL-1β in the lungs in response to virulent mycobacteria and “accelerated” deleterious inflammation, which was highly exacerbated in IFN-γR−/−mice. Regulatory [MHC… Show more
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