Dual nanozyme based on ultrathin 2D conductive MOF nanosheets intergraded with gold nanoparticles for electrochemical biosensing of H2O2 in cancer cells

Huang, Wei; Xu, Yun; Wang, Zhanpeng; Liao, Kin; Zhang, Yan; Sun, Yimin

doi:10.1016/j.talanta.2022.123612

Cited by 46 publications

(29 citation statements)

References 36 publications

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“…Table 2 demonstrates various electrochemical-based detecting platforms for the highly sensitive determination of H 2 O 2 and some of the electrochemical research works have been described here. Huang et al [ 61 ] developed a sensitive electrochemical sensing platform based on an active dual nanozyme amplified process by applying conductive MOF (C-MOF) nanosheets (NSs). These composites were fabricated from Au NPs and utilized in H 2 O 2 recognition, a biomarker for cancer in living cells.…”

Section: Highly Sensitive Electrochemical Sensing and Biosensing Assa...mentioning

confidence: 99%

Electrochemical-Based Sensing Platforms for Detection of Glucose and H2O2 by Porous Metal–Organic Frameworks: A Review of Status and Prospects

et al. 2023

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Establishing enzyme-free sensing assays with great selectivity and sensitivity for glucose and H2O2 detection has been highly required in biological science. In particular, the exploitation of nanomaterials by using noble metals of high conductivity and surface area has been widely investigated to act as selective catalytic agents for molecular recognition in sensing platforms. Several approaches for a straightforward, speedy, selective, and sensitive recognition of glucose and H2O2 were requested. This paper reviews the current progress in electrochemical detection using metal–organic frameworks (MOFs) for H2O2 and glucose recognition. We have reviewed the latest electrochemical sensing assays for in-place detection with priorities including straightforward procedure and manipulation, high sensitivity, varied linear range, and economic prospects. The mentioned sensing assays apply electrochemical systems through a rapid detection time that enables real-time recognition. In profitable fields, the obstacles that have been associated with sample preparation and tool expense can be solved by applying these sensing means. Some parameters, including the impedance, intensity, and potential difference measurement methods have permitted low limit of detections (LODs) and noticeable durations in agricultural, water, and foodstuff samples with high levels of glucose and H2O2.

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Section: Highly Sensitive Electrochemical Sensing and Biosensing Assa...mentioning

confidence: 99%

Electrochemical-Based Sensing Platforms for Detection of Glucose and H2O2 by Porous Metal–Organic Frameworks: A Review of Status and Prospects

et al. 2023

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“…In this regard, it was reported that the electrode engineered with ultra-thin 2D MOF M-TCPP (M = Cu, Co and Ni) nanofilms (1–3 nm) and 2D MOF nanosheets with a thickness of 6–10 nm along with carbon nanosheets obtained from CNT and GO can effectively detect H 2 O 2 with improved LOD (5 nM) at the linear range of 0.01–3.75 µM and 3.75–377.75 µM compared to 2D MOF M-TCPP [ 71 ]. Recently, in order to increase the LOD of cancer cells by sensing the generated H 2 O 2 , Huang and coworkers [ 72 ] by designing ultra-thin 2D MOF nanosheets based on hybridizing copper nanozymes with Au nanozymes in a non-aggregative form with dual enzyme-like activity were able to remarkably improve the detection of colon cancer cells. They showed that the structural changes induced through the hybridization of Cu nanozymes with Au can improve the LOD of H 2 O 2 up to 5.6 nM with a high sensitivity of 188.1 µA/cm 2 /mM [ 72 ].…”

Section: Application Of Core-shell Mofs In the Development Of Biosens...mentioning

confidence: 99%

Electrochemical aptasensor based on the engineered core-shell MOF nanostructures for the detection of tumor antigens

et al. 2023

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It is essential to develop ultrasensitive biosensors for cancer detection and treatment monitoring. In the development of sensing platforms, metal-organic frameworks (MOFs) have received considerable attention as potential porous crystalline nanostructures. Core-shell MOF nanoparticles (NPs) have shown different diversities, complexities, and biological functionalities, as well as significant electrochemical (EC) properties and potential bio-affinity to aptamers. As a result, the developed core-shell MOF-based aptasensors serve as highly sensitive platforms for sensing cancer biomarkers with an extremely low limit of detection (LOD). This paper aimed to provide an overview of different strategies for improving selectivity, sensitivity, and signal strength of MOF nanostructures. Then, aptamers and aptamers-modified core-shell MOFs were reviewed to address their functionalization and application in biosensing platforms. Additionally, the application of core-shell MOF-assisted EC aptasensors for detection of several tumor antigens such as prostate-specific antigen (PSA), carbohydrate antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), human epidermal growth factor receptor-2 (HER2), cancer antigen 125 (CA-125), cytokeratin 19 fragment (CYFRA21-1), and other tumor markers were discussed. In conclusion, the present article reviews the advancement of potential biosensing platforms toward the detection of specific cancer biomarkers through the development of core-shell MOFs-based EC aptasensors.

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“…MOFs exhibit a wide variety of potential applications in catalysis, gas storage and separation, luminescence, and drug delivery, owing to their specific features, such as structural diversity, flexibility and tailorability, high porosity, large surface area, and extraordinary adsorption affinities [1]. In electrochemical biosensing MOFs were used for determination of cancer biomarkers [2], heavy metals [3], herbicides [4], H2O2 [5], bisphenol A [6] and other analytes.…”

Section: Introductionmentioning

confidence: 99%

“…In the past, a lot of MOFs with different linkers and metal ions were synthesized and applied as sensing receptors in electrochemical sensors. Significant portion of these MOFs are based on copper(I) or (II) ions because of their high catalytic activity and low cost [1,5,6,[10][11][12]; besides, copper ions form a strong coordination bond with creatinine: from 2 to 4 creatinine molecules per one Cu 2+ ion [13].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical creatinine determination with metal-organic framework catalyst based on copper and acetylenedicarboxylic acid

et al. 2023

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Fast and accurate determination of creatinine is critical in kidney function diagnostics. This paper discusses the usage of the metal-organic framework based on copper(II) and acetylenedicarboxylic acid (CuADCA) as a catalyst of electrochemical oxidation of creatinine, glucose and urea. CuADCA was synthesized by deprotonation with triethylamine for the first time. Successful synthesis was confirmed by FTIR and EDS. The material was characterized by SEM, EIS, and CV. CuADCA forms laminated-like flakes with diameter from 1 µm to 20 µm, which is consistent with the polymer-like structure. CV and EIS analyses showed that CuADCA immobilized on GCE acts as a catalyst in electrooxidation reaction of glucose, urea, and creatinine. The sensitivity of creatinine detection, 1057±99 µA/mM, was higher than the detection sensitivity of glucose and urea by more than 100 times with the limit of detection of 2 µM, so CuADCA is a promising material for further development of enzymeless sensors for creatinine.

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Dual nanozyme based on ultrathin 2D conductive MOF nanosheets intergraded with gold nanoparticles for electrochemical biosensing of H2O2 in cancer cells

Cited by 46 publications

References 36 publications

Electrochemical-Based Sensing Platforms for Detection of Glucose and H2O2 by Porous Metal–Organic Frameworks: A Review of Status and Prospects

Electrochemical-Based Sensing Platforms for Detection of Glucose and H2O2 by Porous Metal–Organic Frameworks: A Review of Status and Prospects

Electrochemical aptasensor based on the engineered core-shell MOF nanostructures for the detection of tumor antigens

Electrochemical creatinine determination with metal-organic framework catalyst based on copper and acetylenedicarboxylic acid

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