Abstract:Alzheimer’s disease (AD) is the most common form of dementia that affects millions of people worldwide. The hallmark of this disease is the accumulation of amyloid-beta (Abeta) aggregates that lead to neuronal death and cognitive defects. Various chemical reagents, including transition metal complexes, have been developed to change Abeta peptides with the consequent impact on their aggregation profiles; however, the examples of Abeta modifications by transition metal complexes are very limited. Here we report,… Show more
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