Dual mode of voltammetric studies on Cu(<scp>ii</scp>) complexes of His2 peptides: phosphate and peptide sequence recognition

Tobolska, Aleksandra; Głowacz, Klaudia; Ciosek-Skibińska, Patrycja; Bal, Wojciech; Wróblewski, Wojciech; Wezynfeld, Nina E.

doi:10.1039/d2dt03078k

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…Then, we used a voltammetric chemical tongue to identify peptides within the group of Pro-Gly, carnosine, glutathione, Aβ 4-16 , and the α-factor N-terminus [ 20 ]. In our last paper, we showed that voltammetric tongue approach enabled recognition of sequence of Aβ 5-9 derivatives, which presents the same Cu(II)-His2 coordination mode, but with modified residues at first and third positions [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Quantum dots-based “chemical tongue” for the discrimination of short-length Aβ peptides

Głowacz,

Drozd,

Tokarska

et al. 2024

Microchim Acta

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A “chemical tongue” is proposed based on thiomalic acid-capped quantum dots (QDs) with signal enrichment provided by excitation-emission matrix (EEM) fluorescence spectroscopy for the determination of close structural analogs—short-length amyloid β (Aβ) peptides related to Alzheimer’s disease. Excellent discrimination is obtained by principal component analysis (PCA) for seven derivatives: Aβ1-16, Aβ4-16, Aβ4-9, Aβ5-16, Aβ5-12, Aβ5-9, Aβ12-16. Detection of Aβ4-16, Aβ4-16, and Aβ5-9 in binary and ternary mixtures performed by QDs-based chemical tongue using partial least squares-discriminant analysis (PLS-DA) provided perfect 100% accuracy for the two studied peptides (Aβ4-16 and Aβ4-16), while for the third one (Aβ5-9) it was slightly lower (97.9%). Successful detection of Aβ4-16 at 1 pmol/mL (1.6 ng/mL) suggests that the detection limit of the proposed method for short-length Aβ peptides can span nanomolar concentrations. This result is highly promising for the development of simple and efficient methods for sequence recognition in short-length peptides and better understanding of mechanisms at the QD-analyte interface. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Quantum dots-based “chemical tongue” for the discrimination of short-length Aβ peptides

Głowacz,

Drozd,

Tokarska

et al. 2024

Microchim Acta

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The effect of histidine, histamine, and imidazole on electrochemical properties of Cu(ii) complexes of Aβ peptides containing His-2 and His-3 motifs

Tobolska,

Jabłońska,

Suwińska

et al. 2024

Dalton Trans.

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Dual mode of voltammetric studies on Cu(ii) complexes of His2 peptides: phosphate and peptide sequence recognition

Abstract: Copper(II) complexes of peptides with a histidine residue at the second position (His2 peptides) provide a unique profile of electrochemical behavior, offering signals of both Cu(II) reduction and Cu(II) oxidation....

Cited by 2 publications

References 35 publications

Quantum dots-based “chemical tongue” for the discrimination of short-length Aβ peptides

Quantum dots-based “chemical tongue” for the discrimination of short-length Aβ peptides

The effect of histidine, histamine, and imidazole on electrochemical properties of Cu(ii) complexes of Aβ peptides containing His-2 and His-3 motifs

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