Abstract:3865
Mediator/TRAP complex, a master transcriptional coregulator, constitutes a subcomplex of RNA polymerase II holoenzyme, and integrates a wide variety of intracellular signals through specific interactions of activators with specific Mediator subunits. Among circa 30 subunits, MED1/TRAP220, in which two LXXLL nuclear receptor recognition motifs (aa.604-608; aa.645-649) are closely situated, was identified initially as a specific coactivator for nuclear receptors, and subsequently as such for … Show more
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