Dual-Mode Electrochemical Competitive Immunosensor Based on Cd2+/Au/Polydopamine/Ti3C2 Composite and Copper-Based Metal–Organic Framework for 17β-Estradiol Detection

Xia, Yide; Liu, Yiwei; Hu, Xiaopeng; Zhao, Faqiong; Zeng, Baizhao

doi:10.1021/acssensors.2c01420

Cited by 18 publications

(5 citation statements)

References 41 publications

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“…Competitive immunosensors are able to combine with multiple types of signal-sensing units. Xia et al (2022) constructed a dual-mode electrochemical competitive immunosensor to detect E2. In their study, an electrode served as the signal-sensing unit.…”

Section: Various Biosensors For Detecting E2mentioning

confidence: 99%

17β-estradiol biosensors based on different bioreceptors and their applications

Wang,

Kong,

Liu

et al. 2024

Front. Bioeng. Biotechnol.

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17β-Estradiol (E2) is a critical sex steroid hormone, which has significant effects on the endocrine systems of both humans and animals. E2 is also believed to play neurotrophic and neuroprotective roles in the brain. Biosensors present a powerful tool to detect E2 because of their small, efficient, and flexible design. Furthermore, Biosensors can quickly and accurately obtain detection results with only a small sampling amount, which greatly meets the detection of the environment, food safety, medicine safety, and human body. This review focuses on previous studies of biosensors for detecting E2 and divides them into non-biometric sensors, enzyme biosensors, antibody biosensors, and aptamer biosensors according to different bioreceptors. The advantages, disadvantages, and design points of various bioreceptors for E2 detection are analyzed and summarized. Additionally, applications of different bioreceptors of E2 detection are presented and highlight the field of environmental monitoring, food and medicine safety, and disease detection in recent years. Finally, the development of E2 detection by biosensor is prospected.

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Section: Various Biosensors For Detecting E2mentioning

confidence: 99%

17β-estradiol biosensors based on different bioreceptors and their applications

Wang,

Kong,

Liu

et al. 2024

Front. Bioeng. Biotechnol.

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“…The respective detection limits were determined to be 0.47 and 5.4 pg mL −1 . Moreover, the dual-mode electrochemical immunosensor showed favorable practicality in the examination of actual samples [81].…”

Section: Two-dimensional-doped Materialsmentioning

confidence: 99%

Electrochemical Detection of Hormones Using Nanostructured Electrodes

Haroon,

Stine

2023

Coatings

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Hormones regulate several physiological processes in living organisms, and their detection requires accuracy and sensitivity. Recent advances in nanostructured electrodes for the electrochemical detection of hormones are described. Nanostructured electrodes’ high surface area, electrocatalytic activity, and sensitivity make them a strong hormone detection platform. This paper covers nanostructured electrode design and production using MOFs, zeolites, carbon nanotubes, metal nanoparticles, and 2D materials such as TMDs, Mxenes, graphene, and conducting polymers onto electrodes surfaces that have been used to confer distinct characteristics for the purpose of electrochemical hormone detection. The use of aptamers for hormone recognition is producing especially promising results, as is the use of carbon-based nanomaterials in composite electrodes. These materials are optimized for hormone detection, allowing trace-level quantification. Various electrochemical techniques such as SWV, CV, DPV, EIS, and amperometry are reviewed in depth for hormone detection, showing the ability for quick, selective, and quantitative evaluation. We also discuss hormone immobilization on nanostructured electrodes to improve detection stability and specificity. We focus on real-time monitoring and tailored healthcare with nanostructured electrode-based hormone detection in clinical diagnostics, wearable devices, and point-of-care testing. These nanostructured electrode-based assays are useful for endocrinology research and hormone-related disease diagnostics due to their sensitivity, selectivity, and repeatability. We conclude with nanotechnology–microfluidics integration and tiny portable hormone-detection devices. Nanostructured electrodes can improve hormone regulation and healthcare by facilitating early disease diagnosis and customized therapy.

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“…Existing electrochemical immunosensors are limited to single-point measurements of target molecules in vitro. Among the molecules studied extensively in this technology, cortisol and other metabolites have received significant attention [175][176][177]. These studies lay the groundwork for future wearable sensors capable of continuously monitoring drug molecules.…”

Section: Electrochemical Immunosensing Technologymentioning

confidence: 99%

Revolutionizing Precision Medicine: Exploring Wearable Sensors for Therapeutic Drug Monitoring and Personalized Therapy

Liu

Xiao

et al. 2023

Biosensors

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Precision medicine, particularly therapeutic drug monitoring (TDM), is essential for optimizing drug dosage and minimizing toxicity. However, current TDM methods have limitations, including the need for skilled operators, patient discomfort, and the inability to monitor dynamic drug level changes. In recent years, wearable sensors have emerged as a promising solution for drug monitoring. These sensors offer real-time and continuous measurement of drug concentrations in biofluids, enabling personalized medicine and reducing the risk of toxicity. This review provides an overview of drugs detectable by wearable sensors and explores biosensing technologies that can enable drug monitoring in the future. It presents a comparative analysis of multiple biosensing technologies and evaluates their strengths and limitations for integration into wearable detection systems. The promising capabilities of wearable sensors for real-time and continuous drug monitoring offer revolutionary advancements in diagnostic tools, supporting personalized medicine and optimal therapeutic effects. Wearable sensors are poised to become essential components of healthcare systems, catering to the diverse needs of patients and reducing healthcare costs.

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Dual-Mode Electrochemical Competitive Immunosensor Based on Cd²⁺/Au/Polydopamine/Ti₃C₂ Composite and Copper-Based Metal–Organic Framework for 17β-Estradiol Detection

Cited by 18 publications

References 41 publications

17β-estradiol biosensors based on different bioreceptors and their applications

17β-estradiol biosensors based on different bioreceptors and their applications

Electrochemical Detection of Hormones Using Nanostructured Electrodes

Revolutionizing Precision Medicine: Exploring Wearable Sensors for Therapeutic Drug Monitoring and Personalized Therapy

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