Dual-Modal Photoacoustic Imaging and Optical Coherence Tomography [Review]

Hosseinaee, Zohreh; Simmons, James A.; Reza, Parsin Haji

doi:10.3389/fphy.2020.616618

Cited by 24 publications

(20 citation statements)

References 177 publications

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“…Consequently, this imaging technique is often used in physiological studies related to the structure of blood vessels and oxygen saturation at the same time [3,15]. A combination of ultrasound and optoacoustic imaging can be used when a greater imaging depth is required than that provided by OCT [16]. In this study, a system combining PAI and FLI was constructed to simultaneously acquire the absorption and fluorescence characteristics of a sample.…”

Section: Discussionmentioning

confidence: 99%

“…This is because, to effectively measure ultrasonic signals, PAI requires an ultrasonic transducer to be in close contact with the sample surface, as well as an ultrasonic impedance matching process. To overcome these limitations while developing a multimodal PAI system, multimodal imaging techniques using noncontact PAI (ncPAI) have been studied [15,16], which can be easily combined with other optical imaging devices by measuring ultrasonic signals using a noncontact method [10][11][12]17]. ncPAI detects the vibrations of the sample surface that are induced by photoacoustic waves generated inside the sample by using optical interference, which does not require the use of a coupling agent (water or gel) for ultrasonic impedance matching.…”

Section: Introductionmentioning

confidence: 99%

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Double-Clad Optical Fiber-Based Multi-Contrast Noncontact Photoacoustic and Fluorescence Imaging System

Shin

Eom

2021

Electronics

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A noncontact photoacoustic and fluorescence dual-modality imaging system is proposed, which integrates a fiber-based fluorescence imaging system with noncontact photoacoustic imaging using a specially fabricated double-cladding fiber (DCF) coupler and a DCF lens. The performance of the DCF coupler and lens was evaluated, and the feasibility of this new imaging system was demonstrated using simple tubing phantoms with black ink and fluorophore. Our imaging results demonstrated that the multimodal imaging technique can simultaneously acquire photoacoustic and fluorescence images without coming into contact with the sample. Consequently, the developed method is the first noncontact scheme among multimodal imaging systems that is integrated with a photoacoustic imaging system, which can provide varied and complementary information about the sample.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Double-Clad Optical Fiber-Based Multi-Contrast Noncontact Photoacoustic and Fluorescence Imaging System

Shin

Eom

2021

Electronics

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“…The OCT and PAI technologies are complementary in imaging depth, imaging resolution, and imaging speed, which promote them a suitable companion for a multimodal imaging system (see Table 1 ). In intravascular PAI-OCT, the IVPA imaging system is able to penetrate deep tissues and provide molecular information about plaque composition, while IVOCT maintains high resolution and depth resolution scattering contrast for lipid-rich plaques [ 26 ]. IVPA imaging integrated with IVUS provides both structure and chemical compositions of arterial walls, which demonstrates the capability of characterizing vulnerable plaque [ 99 ].…”

Section: Research Progress and Applications Of Laser Technology In Intravascular Imaging And Treatmentmentioning

confidence: 99%

“…We introduce the state of the art of PAI and OCT, where laser technology is both utilized. In order to overcome the limitations of different imaging methods, multimodal imaging concepts have been considered in recent years [ 26 ]. Moreover, we summarize PAI and OCT by contrasting the strengths and limitations of each modality, as well as highlighting the potential applications of a multimodal system.…”

Section: Introductionmentioning

confidence: 99%

Review on Laser Technology in Intravascular Imaging and Treatment

Li¹,

Shang²,

Ye³

et al. 2022

Aging and disease

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Blood vessels are one of the most essential organs, which nourish all tissues in our body. Once there are intravascular plaques or vascular occlusion, other organs and circulatory systems will not work properly. Therefore, it is necessary to detect abnormal blood vessels by intravascular imaging technologies for subsequent vascular treatment. The emergence of lasers and fiber optics promotes the development of intravascular imaging and treatment. Laser imaging techniques can obtain deep vascular images owing to light scattering and absorption properties. Moreover, photothermal and photomechanical effects of laser make it possible to treat vascular diseases accurately. In this review, we present the research progress and applications of laser techniques in intravascular imaging and treatment. Firstly, we introduce intravascular optical coherent tomography and intravascular photoacoustic imaging, which can obtain various information of plaques. Multimodal intravascular imaging techniques provide more information about intravascular plaques, which have an essential influence on intravascular imaging. Secondly, two laser techniques including laser angioplasty and endovenous laser ablation are discussed for the treatment of arterial and venous diseases, respectively. Finally, the outlook of laser techniques in blood vessels, as well as the integration of laser imaging and treatment are prospected in the section of discussions.

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“…A major technological limitation of current OCT-PAI systems is the imaging speed mismatch between the two modalities. 1,148 Although modern OCT technology permits video rate imaging, PAI systems, especially when PAT is applied, are much slower. Recent advances in high-speed PAI have pointed the way for novel real-time OCT-PAT systems.…”

Section: Outlook Of Oct-paimentioning

confidence: 99%

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

et al. 2021

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Significance: After three decades, more than 75,000 publications, tens of companies being involved in its commercialization, and a global market perspective of about USD 1.5 billion in 2023, optical coherence tomography (OCT) has become one of the fastest successfully translated imaging techniques with substantial clinical and economic impacts and acceptance.Aim: Our perspective focuses on disruptive forward-looking innovations and key technologies to further boost OCT performance and therefore enable significantly enhanced medical diagnosis.Approach: A comprehensive review of state-of-the-art accomplishments in OCT has been performed. Results:The most disruptive future OCT innovations include imaging resolution and speed (single-beam raster scanning versus parallelization) improvement, new implementations for dual modality or even multimodality systems, and using endogenous or exogenous contrast in these hybrid OCT systems targeting molecular and metabolic imaging. Aside from OCT angiography, no other functional or contrast enhancing OCT extension has accomplished comparable clinical and commercial impacts. Some more recently developed extensions, e.g., optical coherence elastography, dynamic contrast OCT, optoretinography, and artificial intelligence enhanced OCT are also considered with high potential for the future. In addition, OCT miniaturization for portable, compact, handheld, and/or cost-effective capsule-based OCT applications, home-OCT, and self-OCT systems based on micro-optic assemblies or photonic integrated circuits will revolutionize new applications and availability in the near future. Finally, clinical translation of OCT including medical device regulatory challenges will continue to be absolutely essential.Conclusions: With its exquisite non-invasive, micrometer resolution depth sectioning capability, OCT has especially revolutionized ophthalmic diagnosis and hence is the fastest adopted imaging technology in the history of ophthalmology. Nonetheless, OCT has not been completely exploited and has substantial growth potential-in academics as well as in industry. This applies not only to the ophthalmic application field, but also especially to the original motivation of OCT to enable optical biopsy, i.e., the in situ imaging of tissue microstructure with a resolution approaching that of histology but without the need for tissue excision.

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Dual-Modal Photoacoustic Imaging and Optical Coherence Tomography [Review]

Cited by 24 publications

References 177 publications

Double-Clad Optical Fiber-Based Multi-Contrast Noncontact Photoacoustic and Fluorescence Imaging System

Double-Clad Optical Fiber-Based Multi-Contrast Noncontact Photoacoustic and Fluorescence Imaging System

Review on Laser Technology in Intravascular Imaging and Treatment

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

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