Dual miRNA-Triggered DNA Walker Assisted by APE1 for Specific Recognition of Tumor Cells
Qianying Zhou,
Tong Li,
Xidong Li
et al.
Abstract:The identification of a specific tumor cell is crucial for the early diagnosis and treatment of cancer. However, it remains a challenge due to the limited sensitivity and accuracy, long response time, and low contrast of the recent approaches. In this study, we develop a dual miRNAtriggered DNA walker (DMTDW) assisted by APE1 for the specific recognition of tumor cells. miR-10b and miR-155 were selected as the research models. Without miR-10b and miR-155 presence, the DNA walker remains inactive as its walking… Show more
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