Dual Mechanism of Action of Curcumin in Experimental Models of Multiple Sclerosis

ELBini-Dhouib, Ines; Manai, Maroua; Neili, Nour-elhouda; Marzouki, Soumaya; Sahraoui, Ghada; Achour, Warda Ben; Zouaghi, Sondes; Benahmed, Melika; Doghri, Raoudha; Srairi-Abid, Najet

doi:10.3390/ijms23158658

Cited by 15 publications

(10 citation statements)

References 70 publications

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“…In relation to melatonin, it has been evaluated in clinical assays related to cranial nerve diseases, multiple sclerosis, epilepsy, sleep disorders, spinal cord injuries, migraine, trauma brain injury, dementia, Huntington, Alzheimer and Parkinson Diseases [ 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 ]. Of note, some of these diseases have also been studied in experimental models, evaluating the neuroprotective effect of these compounds mainly by their antioxidant and anti-inflammatory properties [ 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 ]. Moreover, the effects of quercetin, melatonin and curcumin have been explored in obese patients in different studies, but they have not proposed gliosis as an important comorbidity [ 2...…”

Section: Protective Role Of Antioxidants In Gliosismentioning

confidence: 99%

Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative

et al. 2022

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Obesity remains a global health problem. Chronic low-grade inflammation in this pathology has been related to comorbidities such as cognitive alterations that, in the long term, can lead to neurodegenerative diseases. Neuroinflammation or gliosis in patients with obesity and type 2 diabetes mellitus has been related to the effect of adipokines, high lipid levels and glucose, which increase the production of free radicals. Cerebral gliosis can be a risk factor for developing neurodegenerative diseases, and antioxidants could be an alternative for the prevention and treatment of neural comorbidities in obese patients. Aim: Identify the immunological and oxidative stress mechanisms that produce gliosis in patients with obesity and propose antioxidants as an alternative to reducing neuroinflammation. Method: Advanced searches were performed in scientific databases: PubMed, ProQuest, EBSCO, and the Science Citation index for research on the physiopathology of gliosis in obese patients and for the possible role of antioxidants in its management. Conclusion: Patients with obesity can develop neuroinflammation, conditioned by various adipokines, excess lipids and glucose, which results in an increase in free radicals that must be neutralized with antioxidants to reduce gliosis and the risk of long-term neurodegeneration.

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Section: Protective Role Of Antioxidants In Gliosismentioning

confidence: 99%

Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative

et al. 2022

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“…In vitro, curcumin reduces the apoptosis of oligodendrocytes and exerts an inhibitory effect on CD4+ T-cell proliferation and differentiation, reducing the levels of secreted proinflammatory cytokines, including IL-6, IL-1β, TGF-β, TNF-α, and others. Curcumin increased serum levels of anti-inflammatory molecules such as TGF-β and IL-10 in EAE mice treated with curcumin [ 128 ]. In addition, curcumin may inhibit the inflammatory response mediated by microglia by inactivating the AXL/JAK2/STAT3 signaling pathway [ 129 ].…”

Section: Molecular Mechanisms Of Polyphenol Action On Neuroinflammati...mentioning

confidence: 99%

“…The administration of curcumin led to a reduction in the activation of TLR4 and TLR9 receptors in CD4+ and CD8+ T-cells [ 133 , 134 ]. Finally, it has been demonstrated that in the brains of cuprizone mice, curcumin treatment not only increased the activity of antioxidant enzymes, such as superoxide dismutase (SOD) and catalase (CAT), and the levels of glutathione (GSH) but decreased demyelination [ 128 ].…”

Section: Molecular Mechanisms Of Polyphenol Action On Neuroinflammati...mentioning

confidence: 99%

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Dietary Polyphenols, Microbiome, and Multiple Sclerosis: From Molecular Anti-Inflammatory and Neuroprotective Mechanisms to Clinical Evidence

Rosa

Lonardo

Cacciapuoti

et al. 2023

IJMS

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Multiple sclerosis (MS) is a multifactorial, immune-mediated disease caused by complex gene-environment interactions. Dietary factors modulating the inflammatory status through the control of the metabolic and inflammatory pathways and the composition of commensal gut microbiota, are among the main environmental factors involved in the pathogenesis of MS. There is no etiological therapy for MS and the drugs currently used, often accompanied by major side effects, are represented by immunomodulatory substances capable of modifying the course of the disease. For this reason, nowadays, more attention is paid to alternative therapies with natural substances with anti-inflammatory and antioxidant effects, as adjuvants of classical therapies. Among natural substances with beneficial effects on human health, polyphenols are assuming an increasing interest due to their powerful antioxidant, anti-inflammatory, and neuroprotective effects. Beneficial properties of polyphenols on the CNS are achieved through direct effects depending on their ability to cross the blood-brain barrier and indirect effects exerted in part via interaction with the microbiota. The aim of this review is to examine the literature about the molecular mechanism underlying the protective effects of polyphenols in MS achieved by experiments conducted in vitro and in animal models of the disease. Significant data have been accumulated for resveratrol, curcumin, luteolin, quercetin, and hydroxytyrosol, and therefore we will focus on the results obtained with these polyphenols. Clinical evidence for the use of polyphenols as adjuvant therapy in MS is restricted to a smaller number of substances, mainly curcumin and epigallocatechin gallate. In the last part of the review, a clinical trial studying the effects of these polyphenols in MS patients will also be revised.

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“…101,102 Also, curcumin is able to activate Th1/Th2/Th17 response, which helps in protecting the neuroimmune and modulate the release of inflammatory cytokines in stimulated astrocytes and declined the clinical manifestation in EAE mice by reduction of demyelination. 103 Curcumin's effects are so dosedependent, it is obviously toxic at high in vitro doses, beyond its use in cancer therapy. 104 The protective effects of curcumin, including anti-amyloid, anti-inflammatory, and antioxidant activities, could be achieved by doses at or below 1 μM.…”

Section: The Anti-inflammatory Antioxidant and Nuroprotective Effects...mentioning

confidence: 99%

Curcumin and targeting of molecular and metabolic pathways in multiple sclerosis

Yazdani,

Zamani,

Majidi

et al. 2023

Cell Biochemistry & Function

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Multiple sclerosis (MS) is a life‐threading disease that poses a great threat to the human being lifestyle. Having said extensive research in the realm of underlying mechanisms and treatment procedures, no definite remedy has been found. Over the past decades, many medicines have been disclosed to alleviate the symptoms and marking of MS. Meanwhile, the substantial efficacy of herbal medicines including curcumin must be underscored. Accumulated documents demonstrated the fundamental role of curcumin in the induction of the various signaling pathways. According to evidence, curcumin can play a role in mitochondrial dysfunction and apoptosis, autophagy, and mitophagy. Also, by targeting the signaling pathways AMPK, PGC‐1α/PPARγ, and PI3K/Akt/mTOR, curcumin interferes with the metabolism of MS. The anti‐inflammatory, antioxidant, and immune regulatory effects of this herbal compound are involved in its effectiveness against MS. Thus, the present review indicates the molecular and metabolic pathways associated with curcumin's various pharmacological actions on MS, as well as setting into context the many investigations that have noted curcumin‐mediated regulatory effects in MS.

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Dual Mechanism of Action of Curcumin in Experimental Models of Multiple Sclerosis

Cited by 15 publications

References 70 publications

Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative

Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative

Dietary Polyphenols, Microbiome, and Multiple Sclerosis: From Molecular Anti-Inflammatory and Neuroprotective Mechanisms to Clinical Evidence

Curcumin and targeting of molecular and metabolic pathways in multiple sclerosis

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