Dual Ligand Enabled Pd-Catalyzed Ortho-Alkylation of Iodoarenes
Xiao-Xia Wang,
Lei Jiao
Abstract:The synthesis of complex polysubstituted aromatic molecules from simple precursors is a central goal in organic chemistry. In this study, we developed an approach for the ortho-alkylation of iodoarenes utilizing a dual ligand catalytic system. By combining Pd/olefin ligand cooperative catalysis with bulky trialkylphosphine ligand-promoted C(sp2)-I reductive elimination, we have established an ortho-alkylative Catellani-type reaction with the aryl-iodine bond reconstruction as the final step, which opens new sy… Show more
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