Dual Kidney Transplants From Very Old or Very Young Donors; Long Term Outcomes and Complications

Laftavi, M. R.; Stephan, Rabie N.; Koholi, R; Paolini, Karoline Silva; Min, Inkee; Dayton, M.; Pankewycz, O.

doi:10.1097/01.tp.0000331850.32152.cb

Cited by 2 publications

(9 citation statements)

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“…) are comparable to ours (respectively 100% and 87.6%), as well as the recipient survival rates at 1 (89.7–100%, Ref. ) and 3 years (80–97.5%, Ref. ), both at 97.4% in our series.…”

Section: Discussionsupporting

confidence: 90%

“…Other DKT series reported graft survival rates at 1 (82–100% Ref. ) and 3 years (76–95%, Ref. ) are comparable to ours (respectively 100% and 87.6%), as well as the recipient survival rates at 1 (89.7–100%, Ref.…”

Section: Discussionsupporting

confidence: 85%

“…Our global rate of explantations of one graft (15.4%) is similar than reported in other studies (2.4–29.4%, Ref. ), as well as the rates of ureteral stenoses (10.3% vs 0–11.1%, Ref. ), ureteral fistulas (2.6% vs 0–17% Ref.…”

Section: Discussionmentioning

confidence: 99%

“…), as well as the rates of ureteral stenoses (10.3% vs 0–11.1%, Ref. ), ureteral fistulas (2.6% vs 0–17% Ref. ), hematomas (15.4% vs 1–35.5%, Ref.…”

Section: Discussionmentioning

confidence: 99%

“…), ureteral fistulas (2.6% vs 0–17% Ref. ), hematomas (15.4% vs 1–35.5%, Ref. ), drained lymphoceles (5.1% vs 1.3–18.6%, Ref.…”

Section: Discussionmentioning

confidence: 99%

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Safety of dual kidney transplantation compared to single kidney transplantation from expanded criteria donors: a single center cohort study of 39 recipients

Mendel¹,

Albano²,

Bentellis³

et al. 2018

Transpl Int

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Our objective was to compare the outcomes of dual kidney transplanataion (DKT) to single kidney transplantation (SKT) performed with grafts from expanded criteria donors (ECD) in recipients ≥65 years, focusing on surgical complications. All kidney transplantations (KT) performed between 2006 and 2014 in our institution were analysed. DKT was indicated according to the criteria of the French national Agence de la Biomedecine. Thirty-nine DKT and 155 SKT were included, with a median follow-up of 36 and 26.5 months, respectively. The rate of early surgical revisions was not significantly higher after DKT (23.1% vs 15.5% (P = 0.2593)) but more venous graft thromboses (12.8% vs 3.2% (P = 0.02)) were reported. The glomerular filtration rate (GFR) 24 months after KT was significantly higher after DKT (45.0 ± 16.3 vs 39.8 ± 13.8 ml/min/1.73m ; P = 0.04) and allowed shorter waiting time without a significant increased risk of surgical revision, excepted for venous graft thrombosis, more frequent after DKT. Graft survivals were not significantly different and GFR was higher after DKT. DKT seems to remain an appropriate strategy to address the growing graft shortage in elderly patients.

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“…) are comparable to ours (respectively 100% and 87.6%), as well as the recipient survival rates at 1 (89.7–100%, Ref. ) and 3 years (80–97.5%, Ref. ), both at 97.4% in our series.…”

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

“…), as well as the rates of ureteral stenoses (10.3% vs 0–11.1%, Ref. ), ureteral fistulas (2.6% vs 0–17% Ref. ), hematomas (15.4% vs 1–35.5%, Ref.…”

Section: Discussionmentioning

confidence: 99%

“…), ureteral fistulas (2.6% vs 0–17% Ref. ), hematomas (15.4% vs 1–35.5%, Ref. ), drained lymphoceles (5.1% vs 1.3–18.6%, Ref.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Safety of dual kidney transplantation compared to single kidney transplantation from expanded criteria donors: a single center cohort study of 39 recipients

Mendel¹,

Albano²,

Bentellis³

et al. 2018

Transpl Int

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Dual kidney transplants from adult marginal donors: Review and perspective

Stratta

Harriman

Gurram

et al. 2022

Clinical Transplantation

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The practice of dual kidney transplantation (DKT) from adult marginal deceased donors (MDDs) dates back to the mid-1990s with initial pioneering experiences reported by the Stanford and Maryland groups, at which time the primary indication was estimated insufficient nephron mass from older donors. Multiple subsequent studies of short and long-term success have been reported focusing on three major aspects of DKT: Identifying appropriate selection criteria and developing scoring systems based on pre-and post-donation factors; refining technical aspects; and analyzing mid-term outcomes. The number of adult DKTs performed in the United States has declined in the past decade and only about 60 are performed annually. For adult deceased donor kidneys meeting double allocation criteria, > 60% are ultimately not transplanted. Deceased donors with limited renal functional capacity represent a large proportion of potential kidneys doomed to either discard or non-recovery. However, DKT may reduce organ discard and optimize the use of kidneys from MDDs. In an attempt to promote utilization of MDD kidneys, the United Network for Organ Sharing introduced new allocation guidelines pursuant to DKT in 2019. The purpose of this review is to chronicle the history of DKT and identify opportunities to improve utilization of MDD kidneys through DKT. K E Y W O R D Sdual kidney transplants, index, kidney discard, kidney donor profile marginal deceased donors, nephron mass INTRODUCTIONFor patients with end stage renal disease (ESRD), kidney transplantation is associated with extended life expectancy, improved quality of life, and has proven to be cost-effective long-term compared to any type of dialysis. 1-6 As of August 2021, the United Network for Organ Sharing (UNOS) national waiting list for solid organ transplantation had nearly 107 000 total candidates, including > 90 000 patients (84.6%) awaiting kidney transplantation. 7 Unfortunately, only 22 817 kidney

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Dual Kidney Transplants From Very Old or Very Young Donors; Long Term Outcomes and Complications

Cited by 2 publications

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Safety of dual kidney transplantation compared to single kidney transplantation from expanded criteria donors: a single center cohort study of 39 recipients

Safety of dual kidney transplantation compared to single kidney transplantation from expanded criteria donors: a single center cohort study of 39 recipients

Dual kidney transplants from adult marginal donors: Review and perspective

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