Dual Kidney Transplantation: A Case-Control Comparison With Single Kidney Transplantation From Standard and Expanded Criteria Donors

Moore, P. R.; Farney, Alan C.; Sundberg, Aimee; Rohr, Michael S.; Hartmann, Erika; Iskandar, Samy S.; Gautreaux, Michael D.; Rogers, Jeffrey; Doares, William; Anderson, Teresa K.; Adams, Patricia L.; Stratta, Robert J.

doi:10.1097/01.tp.0000266579.11595.95

Cited by 43 publications

(52 citation statements)

References 12 publications

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“…Previous studies have reported comparable allograft survival between carefully selected DKT and single kidney transplants (2)(3)(4)(5)(6)(7)(11)(12)(13)(14). Moore et al (15) recently reported results from a single center case control study comparing outcomes of 16 DKT, with ECD and SCD transplants and reported similar 2-year patient and allograft survival between DKT, SCD, and ECD transplants. However, they noted higher rates of DGF and complication rates in the SCD group than reported norms.…”

Section: Discussionmentioning

confidence: 80%

Outcomes of Dual Adult Kidney Transplants in the United States: An Analysis of the OPTN/UNOS Database

Gill

Cho²,

Danovitch³

et al. 2008

Transplantation

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Section: Discussionmentioning

confidence: 80%

Outcomes of Dual Adult Kidney Transplants in the United States: An Analysis of the OPTN/UNOS Database

Gill

Cho²,

Danovitch³

et al. 2008

Transplantation

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“…Two of the 10 donors whose kidneys were used in a DKT in Lee's study did not fit an ECD definition . Andres, Remuzzi, Johnson, D'Arcy, Veroux M, Gaber, Moore, and Veroux P all used a biopsy score to determine dual allocation . Ekser used a biopsy score if the patient had elevated creatinine, hypertension, or diabetes as well as being over 60.…”

Section: Resultsmentioning

confidence: 99%

“…DKT has been shown to be effective when appropriate donors and recipients are chosen. Although DKT may involve greater anesthetic and surgical risk, it is associated with significantly higher rates of immediate graft function, especially when kidneys are acquired from extended criteria donors …”

Section: Introductionmentioning

confidence: 99%

Dual kidney transplant techniques: A systematic review

Cocco

Shahrestani

Cocco

et al. 2017

Clinical Transplantation

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“…In patients awaiting kidney transplantation alone, some studies have evaluated an approach that involves transplanting both kidneys from a single donor when an individual kidney from such a donor may be deemed unsuitable and discarded. Transplanting both kidneys together is thought to offset the decrease in quality, with some studies demonstrating comparable recipient outcomes to those seen with single‐kidney transplantation using extended criteria donor (ECD) organs …”

mentioning

confidence: 99%

Combined Dual‐Kidney Liver Transplantation in the United States: A Review of United Network for Organ Sharing/Organ Procurement and Transplantation Network Data Between 2002 and 2012

et al. 2018

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In kidney-alone recipients, dual-kidney transplantation using "higher-risk" donor organs has shown outcomes comparable to those of single-kidney transplantation using extended criteria donor (ECD) organs. To investigate the feasibility of a similar approach with combined kidney-liver transplantation, we identified 22 dual-kidney liver transplantations (DKLTs) and 3044 single-kidney liver transplantations (SKLTs) performed in the United States between 2002 and 2012 using United Network for Organ Sharing/Organ Procurement and Transplantation Network registry data. We compared donor/recipient characteristics as well as graft/recipient survival between DKLT recipients and SKLT recipients of "higher-risk" kidneys (ECD and high kidney donor profile index [KDPI; >85%] donors). Despite having overall similar donor and recipient characteristics compared with both "higher-risk" donor groups, recipient survival in the DKLT group at 36 months was markedly inferior at 40.9% (compared with 67.5% for ECD SKLT recipients and 64.5% for high-KDPI SKLT recipients); nondeath-censored graft survival did not differ. Death was the most common cause of graft loss in all groups. Contrary to dual-kidney transplantation data in kidney-alone recipients, DKLT recipients in our study had inferior survival when compared with SKLT recipients of "higher-risk" donor kidneys. These findings would suggest that dual kidney-liver transplantation has an uncertain role as a strategy to expand the existing kidney donor pool in combined transplantation.

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Dual Kidney Transplantation: A Case-Control Comparison With Single Kidney Transplantation From Standard and Expanded Criteria Donors

Abstract: DKT using kidneys from marginal ECDs is a viable option to counteract the growing shortage of available organs. Excellent short-term results and renal function can be achieved with older, low nephron mass donors provided that both kidneys are transplanted into a single recipient.

Cited by 43 publications

References 12 publications

Outcomes of Dual Adult Kidney Transplants in the United States: An Analysis of the OPTN/UNOS Database

Outcomes of Dual Adult Kidney Transplants in the United States: An Analysis of the OPTN/UNOS Database

Dual kidney transplant techniques: A systematic review

Combined Dual‐Kidney Liver Transplantation in the United States: A Review of United Network for Organ Sharing/Organ Procurement and Transplantation Network Data Between 2002 and 2012

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