Dual interleaved 1H and proton‐decoupled‐31P in Vivo chemical shift imaging of human brain

Gonen, Oded; Hu, Jiani; Murphy‐Boesch, Joseph; Stoyanova, Radka; Brown, Truman R.

doi:10.1002/mrm.1910320114

Cited by 21 publications

(15 citation statements)

References 33 publications

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“…Nonproton, or X-nuclear, studies give access to information not available from proton detection alone. For example, 31 P is used to investigate metabolism via high energy phosphates (1,2), 13 C provides information about glucose and glycogen metabolism (3)(4)(5), and 23 Na may be used to assess the viability of healthy and tumorous tissue (6)(7)(8) or cartilage defects (9).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous and interleaved acquisition of NMR signals from different nuclei with a clinical MRI scanner

Meyerspeer

Magill

Kuehne

et al. 2016

Magnetic Resonance in Med

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Purpose: Modification of a clinical MRI scanner to enable simultaneous or rapid interleaved acquisition of signals from two different nuclei. Methods: A device was developed to modify the local oscillator signal fed to the receive channel(s) of an MRI console. This enables external modification of the frequency at which the receiver is sensitive and rapid switching between different frequencies. Use of the device was demonstrated with interleaved and simultaneous 31 P and 1 H spectroscopic acquisitions, and with interleaved 31 P and 1 H imaging. Results: Signal amplitudes and signal-to-noise ratios were found to be unchanged for the modified system, compared with data acquired with the MRI system in the standard configuration. Conclusion: Interleaved and simultaneous 1 H and 31 P signal acquisition was successfully demonstrated with a clinical MRI scanner, with only minor modification of the RF architecture. While demonstrated with 31 P, the modification is applicable to any detectable nucleus without further modification, enabling a wide range of simultaneous and interleaved experiments to be performed within a clinical setting.

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Section: Introductionmentioning

confidence: 99%

Simultaneous and interleaved acquisition of NMR signals from different nuclei with a clinical MRI scanner

Meyerspeer

Magill

Kuehne

et al. 2016

Magnetic Resonance in Med

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“…Refocused insensitive nucleus enhancement by polarization transfer (RINEPT) (Gonen et al , 1997)) or acquisition schemes (e.g. dual interleaved acquisition of 1 H and 31 P CSI (Gonen et al , 1994), may be useful in increasing SNR and reducing measurement times. Recent studies focusing on applying compressed sensing (Candes et al , 2006) to MRI (Lustig et al , 2008) and MRS (von Morze et al , 2012) are exciting and may improve temporal and spatial resolution significantly with the potential of making 31 P MRSI more clinically applicable in the future.…”

Section: 0 Preclinical 31p Mr Spectroscopy Of Solid Tumorsmentioning

confidence: 99%

High-field small animal magnetic resonance oncology studies

et al. 2013

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This review focuses on the applications of high magnetic field magnetic resonance imaging (MRI) and spectroscopy (MRS) to cancer studies in small animals. High field MRI can provide information about tumor physiology, the microenvironment, metabolism, vascularity and cellularity. Such studies are invaluable for understanding tumor growth and proliferation, response to treatment and drug development. The MR techniques reviewed here include 1H, 31P, Chemical Exchange Saturation Transfer (CEST) imaging, and hyperpolarized 13C MR spectroscopy as well as diffusion-weighted, Blood Oxygen Level Dependent (BOLD) contrast imaging, and dynamic contrast-enhanced MR imaging. These methods have been proven effective in animal studies and are highly relevant to human clinical studies.

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“…itate all of these 1 H requirements during a 31 P study, our team designed several doublee-tuned RF antennas with highly sensitive 31 P and 1 H channels. Moreover, with these double-tuned antennas, 31 P and 1 H spectroscopy can be carried simultaneously, thereby minimizing adjustment and image requirements [15][16][17]. A comparison of the double-tuned probes with conven-tional, single-tuned ones showed that, despite double tuning, there is no significant loss in 31 P sensitivity when the 1 H channel provides the needed performance.…”

Section: T)mentioning

confidence: 99%

In Vivo Measurement of Phosphorous Markers of Disease

Arias‐Mendoza

Brown²

2004

Disease Markers

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Phosphorus Magnetic Resonance Spectroscopy (31P-MRS) has been utilized to study energy, carbohydrate, and phospholipid metabolism in vitro and in vivo in live tissues non-invasively. Despite its lack of sensitivity, its application has extended to in situ human tissues and organs since proper signal localization was devised. Follow-up of phosphocreatine in neuromuscular diseases and schizophrenia and follow-up of phospholipid-related molecules in tumors are described here to demonstrate the value of 31P-MRS as an imaging technique to determine in vivo markers of disease and in the diagnosis, prognosis, and follow-up of human diseases.

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Dual interleaved ¹H and proton‐decoupled‐³¹P in Vivo chemical shift imaging of human brain

Cited by 21 publications

References 33 publications

Simultaneous and interleaved acquisition of NMR signals from different nuclei with a clinical MRI scanner

Simultaneous and interleaved acquisition of NMR signals from different nuclei with a clinical MRI scanner

High-field small animal magnetic resonance oncology studies

In Vivo Measurement of Phosphorous Markers of Disease

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