Dual Inhibition of Factor XIIa and Factor XIa Produces a Synergistic Anticoagulant Effect
Shuai Jiang,
Yitong Li,
Jiali Zhang
et al.
Abstract:Clinical practice shows that a critical unmet need in the field of thrombosis prevention is the availability of anticoagulant therapy without bleeding risk. Inhibitors against FXIa or FXIIa have been extensively studied because of their low bleeding risk. However, whether these compounds produce synergistic effects has not yet been explored. Here, analyses of activated partial thromboplastin time (aPTT) in combination with the FXIa inhibitor PN2KPI and the FXIIa inhibitor Infestin4 at different proportions wer… Show more
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