Dual infections by influenza A/H3N2 and B viruses and by influenza A/H3N2 and A/H1N1 viruses during winter 2007, Corsica Island, France

Falchi, Alessandra; Arena, Christophe; Andréoletti, Laurent; Jacques, Jérôme; Lévêque, Nicolas; Blanchon, Thierry; Lina, Bruno; Turbelin, Clément; Dorléans, Yves; Flahault, Antoine; Amoros, Jean Pierre; Spadoni, G.; Agostini, F.; Varesi, Laurent

doi:10.1016/j.jcv.2007.11.003

Cited by 58 publications

(54 citation statements)

References 19 publications

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“…In fact, dual infections have been documented among people of different age-groups and both in immunocompromised patients, thus suggesting a potential role of the immunological state of the host (Toda et al, 2006;Almajhdi and Ali, 2013), and in ''healthy'' patients without clinical complications (Shimada et al, 2006;Toda et al, 2006;Falchi et al, 2008;Ju et al, 2010), as also described in the present paper. Moreover, the fact that most clinical manifestations observed in dual infections are quite similar to those of single infections, characterized by self-limiting mild classical symptoms, does not support the hypothesis of an association between co-infection and severity of disease.…”

Section: Discussionsupporting

confidence: 73%

“…pdf]. Although co-infection with both influenza A and B viruses appears to be a rare event (Falchi et al, 2008;Almajhdi and Ali, 2013), in this study we describe the detection of a single case of co-infection caused by influenza A(H 1 N 1 )pdm09 and B viruses in Sicily during the 2012-2013 influenza epidemic.…”

Section: Introductionmentioning

confidence: 78%

“…Dual infection with influenza viruses represents an infrequent event and, to date, only few papers have been published mainly reporting A(H 3 N 2 ) and B co-infections (Shimada et al, 2006;Toda et al, 2006;Falchi et al, 2008;Eshaghi et al, 2009), with just one case of co-infection attributed to influenza virus A(H 1 N 1 ) pdm09 and B (Calistri et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Occurrence of a case of influenza A(H1N1)pdm09 and B co-infection during the epidemic season 2012–2013

Tramuto

Maida

Magliozzo³

et al. 2014

Infection, Genetics and Evolution

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a b s t r a c tWe report the detection of one case of co-infection with influenza A(H 1 N 1 )pdm09 and B, occurred during the 2012-2013 influenza season in Sicily. The dual infection was identified in a 18-year-old boy, who was not covered by specific vaccination and who had no other pre-existing risk factors. He presented classical symptoms of influenza-like illness developing no respiratory complications. A(H 1 N 1 )pdm09 viral concentration was initially about 10-fold higher than B virus, whereas its clearance was more rapidly achieved than in the case of B virus infection. Although influenza co-infection appears to be a rare event, a continued influenza surveillance activity is recommended, in order to evaluate diversity and evolution, but also to support public health prevention measures.

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Occurrence of a case of influenza A(H1N1)pdm09 and B co-infection during the epidemic season 2012–2013

Tramuto

Maida

Magliozzo³

et al. 2014

Infection, Genetics and Evolution

View full text Add to dashboard Cite

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“…subtypes/strains, co-infection of influenza viruses in humans is believed to be a rare event [19]. The co-infection rate determined in one study performed recently in New Zealand was 1.1% [20], whereas another study estimated this rate to be about 3% [21].…”

Section: Discussionmentioning

confidence: 99%

Heterologous interactions between NS1 proteins from different influenza A virus subtypes/strains

Zhang

Wang

et al. 2012

Sci. China Life Sci.

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“…Few investigations have addressed influenza coinfection in humans: in Japan coinfections with A/H3N2 or A/H1N1 and influenza B viruses were detected in 2004/2005 (9, 10), and in Corsica, France, in 2007 (11). In September 2009, six patients in Beijing, China, became coinfected with pdm/H1N1 and A/H3N2, but reassortment between the two viruses was not detected (12).…”

mentioning

confidence: 99%

Pandemic Seasonal H1N1 Reassortants Recovered from Patient Material Display a Phenotype Similar to That of the Seasonal Parent

Sonnberg

Ducatez

DeBeauchamp

et al. 2016

J Virol

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We have previously shown that 11 patients became naturally coinfected with seasonal H1N1 (A/H1N1) and pandemic H1N1 (pdm/H1N1) during the Southern hemisphere winter of 2009 in New Zealand. Reassortment of influenza A viruses is readily observed during coinfection of host animals and in vitro; however, reports of reassortment occurring naturally in humans are rare. Using clinical specimen material, we show reassortment between the two coinfecting viruses occurred with high likelihood directly in one of the previously identified patients. Despite the lack of spread of these reassortants in the community, we did not find them to be attenuated in several model systems for viral replication and virus transmission: multistep growth curves in differentiated human bronchial epithelial cells revealed no growth deficiency in six recovered reassortants compared to A/H1N1 and pdm/H1N1 isolates. Two reassortant viruses were assessed in ferrets and showed transmission to aerosol contacts. This study demonstrates that influenza virus reassortants can arise in naturally coinfected patients. IMPORTANCEReassortment of influenza A viruses is an important driver of virus evolution, but little has been done to address humans as hosts for the generation of novel influenza viruses. We show here that multiple reassortant viruses were generated during natural coinfection of a patient with pandemic H1N1 (2009) and seasonal H1N1 influenza A viruses. Though apparently fit in model systems, these reassortants did not become established in the wider population, presumably due to herd immunity against their seasonal H1 antigen. Few investigations have addressed influenza coinfection in humans: in Japan coinfections with A/H3N2 or A/H1N1 and influenza B viruses were detected in 2004/2005 (9, 10), and in Corsica, France, in 2007 (11). In September 2009, six patients in Beijing, China, became coinfected with pdm/H1N1 and A/H3N2, but reassortment between the two viruses was not detected (12). In October 2009, two patients in Cambodia were also found to be coinfected with pdm/H1N1 and A/H3N2 (13). Patient material was plaque purified on MDCK cells, and six virus plaques were examined: no reassortment between the coinfecting viruses was detected (13). Recently, Rith et al. (14) reported reassortment between pdm/H1N1 and A/H3N2 in a naturally coinfected patient, and several groups have detected coinfection of avian H7N9 and human H1N1, H3N2, and influenza B viruses in human patients (14-17).In our study, we sought to (i) determine whether reassortant viruses could be recovered from clinical material from individuals naturally coinfected with different H1N1 viruses and (ii) assess the relative fitness of these reassortants compared to parental A/H1N1 and pdm/H1N1. MATERIALS AND METHODSCell culture. Madin-Darby canine kidney (MDCK) cells were obtained from the American Type Culture Collection and maintained in minimal essential medium (MEM; Gibco, Grand Island, NY) plus 5% fetal calf serum, antibiotic-antimycotic medium (Gibco), vitamins (Gibc...

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Dual infections by influenza A/H3N2 and B viruses and by influenza A/H3N2 and A/H1N1 viruses during winter 2007, Corsica Island, France

Cited by 58 publications

References 19 publications

Occurrence of a case of influenza A(H1N1)pdm09 and B co-infection during the epidemic season 2012–2013

Occurrence of a case of influenza A(H1N1)pdm09 and B co-infection during the epidemic season 2012–2013

Heterologous interactions between NS1 proteins from different influenza A virus subtypes/strains

Pandemic Seasonal H1N1 Reassortants Recovered from Patient Material Display a Phenotype Similar to That of the Seasonal Parent

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