Dual infection with Bordetella pertussis and Mycoplasma pneumoniae in three infants: case reports

Zouari, Asma; Touati, Arabella; Smaoui, H.; Brun, Delphine; Kasdaghli, K.; Menif, Khaled; Jaballah, N. Ben; Hassen, E. Ben; Guiso, Nicole; Kechrid, A.

doi:10.1007/s15010-011-0179-4

Cited by 10 publications

(15 citation statements)

References 21 publications

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“…Co-detection of B. pertussis with other respiratory agents has already been reported,12 , 22 , 26 - 29 and it may be actually underestimated 1213 It was reported that pertussis toxin may suppress innate immune response and sensitize the host to a secondary respiratory pathogen 13.…”

Section: Discussionmentioning

confidence: 99%

“…- 13 Mixed respiratory infections have been reported in children in several countries,14 but its actual incidence is believed to be even higher 1213 …”

Section: Introductionmentioning

confidence: 99%

“…- 13 Infecções respiratórias mistas foram relatadas em crianças em vários países,14 mas acredita-se que sua verdadeira incidência seja ainda maior 1213 …”

Section: Introductionunclassified

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Clinical, laboratorial and radiographic predictors of Bordetella pertussis infection

Bellettini

Oliveira

Tusset

et al. 2014

Rev. paul. pediatr.

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Section: Discussionmentioning

confidence: 99%

“…- 13 Mixed respiratory infections have been reported in children in several countries,14 but its actual incidence is believed to be even higher 1213 …”

Section: Introductionmentioning

confidence: 99%

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Clinical, laboratorial and radiographic predictors of Bordetella pertussis infection

Bellettini

Oliveira

Tusset

et al. 2014

Rev. paul. pediatr.

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“…In some cases, pertussis infection may be followed by synergistic superimposed bacterial and viral infections. These coinfecting pathogens include parainfluenza virus, RSV, Mycoplasma pneumoniae, adenovirus, and influenza A and B viruses (317,(320)(321)(322)(323). Selected reports also identified B. pertussis coinfections with helminthic and parasitic pathogens, including Plasmodium falciparum and Fasciola hepatica (324,325).…”

Section: Complications Of Pertussis In Infants Children and Adultsmentioning

confidence: 99%

Pertussis: Microbiology, Disease, Treatment, and Prevention

et al. 2016

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SUMMARYPertussis is a severe respiratory infection caused byBordetella pertussis, and in 2008, pertussis was associated with an estimated 16 million cases and 195,000 deaths globally. Sizeable outbreaks of pertussis have been reported over the past 5 years, and disease reemergence has been the focus of international attention to develop a deeper understanding of pathogen virulence and genetic evolution ofB. pertussisstrains. During the past 20 years, the scientific community has recognized pertussis among adults as well as infants and children. Increased recognition that older children and adolescents are at risk for disease and may transmitB. pertussisto younger siblings has underscored the need to better understand the role of innate, humoral, and cell-mediated immunity, including the role of waning immunity. Although recognition of adult pertussis has increased in tandem with a better understanding ofB. pertussispathogenesis, pertussis in neonates and adults can manifest with atypical clinical presentations. Such disease patterns make pertussis recognition difficult and lead to delays in treatment. Ongoing research using newer tools for molecular analysis holds promise for improved understanding of pertussis epidemiology, bacterial pathogenesis, bioinformatics, and immunology. Together, these advances provide a foundation for the development of new-generation diagnostics, therapeutics, and vaccines.

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“…13 Improved diagnostic testing has also increased the recognition and clinical implications of respiratory co-infections. 13,229,282,283 In the clinical setting, rapid identification of the aetiology of respiratory infections would improve patient management and possibly lead to a reduction in healthcare costs. 257,284,285 While viruses are more commonly responsible for acute respiratory infections in children and adults, it is difficult to distinguish the clinical history and symptoms of viral infections from bacterial infections.…”

Section: Clinicalmentioning

confidence: 99%

The diagnosis and epidemiology of pertussis in Australia

Kaczmarek¹

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Pertussis, more commonly known as whooping cough, is one of the most common vaccine-preventable infections reported in Australia. In the last decade, pertussis incidence has increased in Australia and overseas, with large sustained epidemics occurring most notably in developed countries. Australia had a pertussis epidemic between 2009 and 2012, which peaked during 2011 with 38,602 notified cases. The role of improved diagnostic methods, particularly the use of polymerase chain reaction (PCR) testing, has been hypothesised to have led to improved case ascertainment and superior detection of disease activity. This Thesis is comprised of five distinct studies contributing to the investigation of this hypothesis.In Australia, the incidence of pertussis is predominantly monitored using notification data, with the case definition for notifications heavily reliant on laboratory confirmation. By analysing pertussis notifications between 1991 and 2013 by diagnostic test method, I was able to demonstrate that PCR quickly replaced all other laboratory methods for pertussis diagnosis from 2005 onwards, with the exception of persisting serology use in a proportion of adolescents and adults. In addition, a change in the age distribution of notifications was observed over time, with increasing pertussis incidence among older children and adolescents.As notification data can be biased by changes in testing practices, awareness, and definitions, my next study investigated pertussis testing trends in the general practice (GP, primary care) setting between 2000 and 2011 using data from the Bettering the Evaluation And Care of Health (BEACH) program. Among a stable set of GP encounters for respiratory illness, it was observed that the likelihood of individuals being tested for pertussis in 2010-2011 was seven times higher compared to ten years earlier. These findings, at least in part, suggest that notifications have been amplified due to increased testing.To gather more information about the contribution of increased testing to the pertussis epidemic, the incidence of severe pertussis cases admitted to intensive care units (ICUs) was reviewed, as the ICU setting is less likely to be biased by changes in diagnostic This Thesis makes an important and original contribution to understanding the recent resurgence of pertussis in Australia and overseas by addressing gaps in knowledge about changes in diagnostic testing. Although a true increase in pertussis incidence occurred in Australia, increasing PCR diagnosis allowed better case detection across all age groups and healthcare settings. Greater understanding of pertussis epidemiology as a result of PCR diagnosis should ultimately improve pertussis immunisation and control programs, through better identification of at-risk groups.iv

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Dual infection with Bordetella pertussis and Mycoplasma pneumoniae in three infants: case reports

Cited by 10 publications

References 21 publications

Clinical, laboratorial and radiographic predictors of Bordetella pertussis infection

Clinical, laboratorial and radiographic predictors of Bordetella pertussis infection

Pertussis: Microbiology, Disease, Treatment, and Prevention

The diagnosis and epidemiology of pertussis in Australia

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