“…(+)-Bacillamide B ( 1 ), originally isolated in the Bahamas in 2007, displays antimicrobial and anti-HIV activities . Non-naturally occurring alcohols alongside their ether and amino derivatives that bear a nitrogen-heteroaromatic ring, such as thiazole ( 2 ), benzimidazole ( 3 ), pyrimidine ( 4 , 5 ), , pyrazine ( 6 ), quinoline ( 7 ), pyridine ( 8 – 10 ), − and imidazole, − are also commonly seen in medicinal chemistry studies, serving as important analogues for treatment of various diseases. For example, JAK2 (Janus kinase 2) inhibitor 5 and PI3Kδ (phosphoinositide-3-kinase δ) inhibitors 3 and 7 can be used to cure inflammatory diseases and cancers, whereas β 3 AR (β 3 adrenergic receptor) agonist 9 is a potential therapeutic agent for obesity.…”