Dual functions of gold nanorods as photothermal agent and autofluorescence enhancer to track cell death during plasmonic photothermal therapy

Kannadorai, Ravi Kumar; Chiew, Geraldine Giap Ying; Luo, Kathy Qian; Liu, Quan

doi:10.1016/j.canlet.2014.11.022

Cited by 39 publications

(15 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both NRs and NPrs exhibit size-dependent optical properties and can be synthesised to exhibit strong absorption in the NIR range. Upon excitation by incident light, sharp local heating can be generated by the photothermal conversion of the absorbed light energy into local heating, rendering these particular anisotropic AuNPs as extremely efficient for NIR-induced heating [15,32]. One limiting factor is that the cationic surfactant CTAB is a well-known highly toxic component, and thus methods to exchange CTAB for other less cytotoxic surfactants or polymer coatings have been extensively reported [22,30,33].…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoprism–Nanorod Face Off: Comparing the Heating Efficiency, Cellular Internalization and Thermoablation Capacity

Alfranca

Artiga

Stepien

et al. 2016

Nanomedicine (Lond.)

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Gold Nanoprism–Nanorod Face Off: Comparing the Heating Efficiency, Cellular Internalization and Thermoablation Capacity

Alfranca

Artiga

Stepien

et al. 2016

Nanomedicine (Lond.)

View full text Add to dashboard Cite

show abstract

“…AuNRs have unique optical and electronic properties that are dependent on the particles' size and aspect ratio [46]. These particles are also anisotropic, which has sparked interest in the biomedical field for applications in drug and gene delivery, as contrast agents in optical imaging, and as PTAs in cancer therapy [45,47,48]. This interest is due to the presence of two electromagnetic absorption peaks with a bandgap that is extremely tunable [45].…”

Section: Gold Nanorodsmentioning

confidence: 99%

Comparison of Four Common Gold Nanoparticles for Photothermal Cancer Therapy: A Review

Saiphoo

Rose

Dunn

et al. 2020

IJEMM

View full text Add to dashboard Cite

Current cancer treatment options, including surgery, chemotherapy and radiation therapy, often cause damage to healthy tissue and reduce a patient's quality of life with well-known side effects, such as pain, infection and nerve damage. Recent research has shown that gold nanoparticles used as photothermal agents in photothermal therapy may pose as an alternative to traditional treatments. This great potential is due to their ability to selectively accumulate in cancerous tissue, efficiently absorb near-infrared light, and kill cancerous tissue without harming surrounding cells. Gold nanoparticles show promise in increasing treatment efficacy and reducing the side effects associated with cancer therapy. While recent studies show the potential of gold nanoparticles, the existing literature is limited in drawing comparisons between studies and practical use for photothermal therapy. This paper reviews notable studies on four common gold nanoparticles used in the therapeutic treatment of cancer: gold nanocages, gold nanospheres, gold nanorods, and gold nanoshells. By comparing key characteristics of the particles’, including their synthesis, toxicity, absorption spectrum, and selective photothermal lethality, gold nanospheres can be recommended for use in photothermal therapy. Although forms of each gold nanoparticle were found to have a low toxicity, gold nanospheres can be rapidly synthesized and appear to exceed in selective photothermal lethality and immature tumour accumulation. Due to these advantages in using gold nanospheres for photothermal therapy, cancer could be treated more effectively and improve patient prognosis.

show abstract

“…Plasmonic photothermal therapy (PPTT) [1][2][3] involves exploiting the light to heat conversion property of gold nanoparticles to localize heating to the desired region. Nanoparticles such as nanorods [1] and nanoshells [1] absorb NIR laser and produce heat and have been successfully used to treat cancers [4] in vivo.…”

Section: Introductionmentioning

confidence: 99%

Gold nanorods as photothermal agents and autofluorescence enhancer to track cell death during plasmonic photothermal therapy

et al. 2015

Self Cite

View full text Add to dashboard Cite

The transverse and longitudinal plasmon resonance in gold nanorods can be exploited to localize the photothermal therapy and influence the fluorescence to monitor the treatment outcome at the same time. While the longitudinal plasmon peak contributes to the photothermal effect, the transverse peak can enhance fluorescence. After cells take in PEGylated nanorods through endocytosis, autofluorescence from endogenous fluorophores such as nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD) in the mitochondria is enhanced two times, which is a good indicator of the respiratory status of the cell. When cells are illuminated continuously with near infrared laser, the temperature reaches the hyperthermic region within the first four minutes, which demonstrates the efficiency of gold nanorods in photothermal therapy. The cell viability test and autofluorescence intensity show good correlation indicating the progress of cell death over time.

show abstract

Dual functions of gold nanorods as photothermal agent and autofluorescence enhancer to track cell death during plasmonic photothermal therapy

Cited by 39 publications

References 57 publications

Gold Nanoprism–Nanorod Face Off: Comparing the Heating Efficiency, Cellular Internalization and Thermoablation Capacity

Gold Nanoprism–Nanorod Face Off: Comparing the Heating Efficiency, Cellular Internalization and Thermoablation Capacity

Comparison of Four Common Gold Nanoparticles for Photothermal Cancer Therapy: A Review

Gold nanorods as photothermal agents and autofluorescence enhancer to track cell death during plasmonic photothermal therapy

Contact Info

Product

Resources

About