Dual-Functionalized MSCs that Express CX3CR1 and IL-25 Exhibit Enhanced Therapeutic Effects on Inflammatory Bowel Disease

Fu, Yong; Ni, Junjun; Chen, Jiahui; Ma, Gailing; Zhao, Mingming; Zhu, Shuaidong; Shi, Tongguo; Zhu, Jie; Huang, Zhen; Zhang, Junfeng; Chen, Jiangning

doi:10.1016/j.ymthe.2020.01.020

Cited by 17 publications

(26 citation statements)

References 45 publications

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“…Intravenously transplanted cells were shown to penetrate the extravascular space of the colon by transendothelial migration. [ 290 ] The high efficiency of the discussed method is its undoubted advantage. At the same time, this technique carries the risk associated with the random placement of the viral carrier into the recipient's genetic material, which can initiate the phenomenon of insertional mutagenesis.…”

Section: Techniques For Increasing the Colonization Of The Lesion Arementioning

confidence: 99%

Mesenchymal Stem Cells for Neurological Disorders

et al. 2021

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Neurological disorders are becoming a growing burden as society ages, and there is a compelling need to address this spiraling problem. Stem cell‐based regenerative medicine is becoming an increasingly attractive approach to designing therapies for such disorders. The unique characteristics of mesenchymal stem cells (MSCs) make them among the most sought after cell sources. Researchers have extensively studied the modulatory properties of MSCs and their engineering, labeling, and delivery methods to the brain. The first part of this review provides an overview of studies on the application of MSCs to various neurological diseases, including stroke, traumatic brain injury, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, Parkinson's disease, and other less frequently studied clinical entities. In the second part, stem cell delivery to the brain is focused. This fundamental but still understudied problem needs to be overcome to apply stem cells to brain diseases successfully. Here the value of cell engineering is also emphasized to facilitate MSC diapedesis, migration, and homing to brain areas affected by the disease to implement precision medicine paradigms into stem cell‐based therapies.

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Section: Techniques For Increasing the Colonization Of The Lesion Arementioning

confidence: 99%

Mesenchymal Stem Cells for Neurological Disorders

et al. 2021

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“…MSCs interact with immune cells, and potentially inhibit localized immune responses via the secretion of regulatory factors, including transforming growth factor β, hepatocyte growth factor and IL-10 (48). The immunomodulatory properties of MSCs have been shown to be effective in acute graft-versus-host disease (49), type 1 diabetes (50), rheumatoid arthritis (51), systemic lupus erythematosus ( 52), inflammatory bowel disease (53) and other immune and inflammation-associated diseases (54). The cells attenuate acute lung injury by inhibiting the infiltration of immune cells and reducing the secretion of inflammatory factors.…”

Section: Mesenchymal Stem Cell (Msc)-based Therapymentioning

confidence: 99%

Immunoregulatory therapy strategies that target cytokine storms in patients with COVID‑19 (Review)

Zhao

2021

Exp Ther Med

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A cytokine storm is an uncontrolled, excessive immune response that contributes to the pathogenesis of coronavirus disease 2019 . Viral infections lead to the loss of negative feedback in immune regulation and an abnormal elevation of the levels of multiple cytokines. In COVID-19, this causes diffuse damage to alveolar functions and may culminate in multiple organ dysfunction. Immunoregulatory therapies target the cytokine storms induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, and include monoclonal antibodies, recombinant granulocyte-macrophage colony stimulating factor, interferon, mesenchymal stem cell-based therapy, thymosin, immunoglobulins and blood purification therapies. These approaches may be effective in the alleviation of COVID-19 symptoms. In this review, cytokine storms caused by SARS-CoV-2 infections are evaluated and discussed, and advances in immunoregulatory therapy strategies for patients with COVID-19 are reviewed. Contents 1. Introduction 2. SARS-CoV-2 and COVID-19 3. Cytokine storm 4. Targeted cytokine storm therapy -the fight against COVID-19 5. Conclusions and perspectives

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“…Full-thickness excision wound healing experiments were conducted based on a reported protocol (Chen et al, 2020). SD Rats (male, 3 weeks, ~200 g, n = 12) were used.…”

Section: The Efficacy Of Mitochondria Transferred Adscs In Wound Healingmentioning

confidence: 99%

“…The immunomodulatory, anti-inflammatory, angiogenic, anti-apoptotic and trophic activities of MSCs, in combination with their ease of isolation and expansion, has led to over 950 registered MSCs clinical trials listed with ClinicalTrials.gov. However, there are several drawbacks in using MSCs: (1) the therapeutic potential of MSCs is highly variable in a complex pathophysiological environment (Sarkar et al, 2011); (2) the overall efficiency of MSCs engraftment to tissue injuries is poor, especially when these cells are systemically administered (Fu et al, 2020). Consequently, there is a need for innovative approaches to endow Ǝ next-generation MSCsƐ with enhanced features and functionalities.…”

Section: Introductionmentioning

confidence: 99%