Dual functionalized brush copolymers as versatile antifouling coatings

Kil, Jihyo; Rahman, Rafia Tasnim; Wang, Wenxuan; Choi, Saehan; Nam, Yoon Sung; Li, Sheng

doi:10.1039/d2tb02522a

Cited by 4 publications

(1 citation statement)

References 57 publications

(89 reference statements)

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“…By forming a brush-like structure on the surface of the microcapsules, PEG gave rise to a "stealth effect," repelling proteins, cells, and bacteria. [28,29] The protein-repellent properties of PEG should be attributed to steric repulsion and excludedvolume effects between proteins and the PEG-modified material surface, [30][31][32] which could effectively avoid excessive formation of fibrotic proliferation on the surface of biomaterials.…”

Section: Antiprotein and Anticell Adsorption Of Abpp Microcapsulesmentioning

confidence: 99%

A Bioartificial Pancreas with “Immune Stealth” and Continuous Oxygen Supply for Islet Transplantation

Zheng,

Yang,

Gao

et al. 2023

Macromol. Rapid Commun.

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Transplantation of microencapsulated islet cells remains a promising strategy for the normalization of glucose metabolism control in type 1 diabetes mellitus. However, vigorous host immunologic rejection, fibrotic overgrowth around the microcapsules and poor oxygen supply often lead to graft failure. Herein, a bioartificial pancreas is constructed that incorporates the “stealth effect” based on polyethylene glycol copolymers and the high oxygen‐carrying performance of fluorinated nanoparticles. Polycationic poly(L‐lysine)‐grafted‐poly(ethylene glycol) is successfully coated on the surface of alginate microcapsules through electrostatic interaction, which can not only resist fibrinogen adhesion and avoid excessive fibrosis around the microcapsules, but also isolate the host immune system from attacking, achieving a “stealth effect” of microencapsulated islet cells. Furthermore, the co‐loading of fluoride‐based O2 nanocarriers gives them enhanced oxygen‐carrying and continuous oxygen supply capabilities, thereby effectively prolonging the survival of islet cells. The intracapsular islet cells still display similar cell viability and almost normal insulin secretion function even in long‐term culture under hypoxic conditions. Collectively, this work opens up a new approach for microencapsulated islets to efficiently evade host immune attack and improve oxygen supply, and provides a promising strategy for islet transplantation in type 1 diabetes mellitus.This article is protected by copyright. All rights reserved

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Section: Antiprotein and Anticell Adsorption Of Abpp Microcapsulesmentioning

confidence: 99%

A Bioartificial Pancreas with “Immune Stealth” and Continuous Oxygen Supply for Islet Transplantation

Zheng,

Yang,

Gao

et al. 2023

Macromol. Rapid Commun.

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Modification strategy of siloxane antifouling coating: adhesion strength, static antifouling, and self-healing properties

Wang,

Chen,

Feng

et al. 2023

Surf. Sci. Tech.

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Siloxane coatings, characterized by their low surface energy and low elastic modulus, exhibit promising fouling-release properties. However, siloxane antifouling coatings still have certain limitations, which include low adhesion strength, poor antifouling performance, and weak mechanical properties. This review summarizes the modification methods of siloxane coatings, and focuses on three modification strategies: improving coating adhesion, static antifouling performance, and self-healing capabilities. This review provides insight into the preparation methods, enhancement mechanism and key critical issues of the three strategies. Additionally, potential research methods and materials that can further augment siloxane coating performance in the future were evaluated. Computational techniques such as molecular dynamics can aid researchers in understanding structural modification strategies at the molecular level. Photocatalytic antifouling agents are more suitable for future scientific and environmentally friendly design concepts. It is hope that this contribution provides valuable insights for researchers seeking a better understanding of advancements in siloxane antifouling coatings research and aids in developing novel solutions to address marine fouling issues.

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Macrophage-Inspired marine antifouling coating with dynamic surfaces based on regulation of dynamic covalent bonds

Wang,

Liu,

Chen

et al. 2024

Journal of Colloid and Interface Science

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Dual functionalized brush copolymers as versatile antifouling coatings

Abstract: Polymer coatings containing both fouling-resistant and fouling-release components have been reported to show synergistic antifouling properties. However, it remains unclear how polymer composition influences antifouling performance, particularly regarding foulants of...

Cited by 4 publications

References 57 publications

A Bioartificial Pancreas with “Immune Stealth” and Continuous Oxygen Supply for Islet Transplantation

A Bioartificial Pancreas with “Immune Stealth” and Continuous Oxygen Supply for Islet Transplantation

Modification strategy of siloxane antifouling coating: adhesion strength, static antifouling, and self-healing properties

Macrophage-Inspired marine antifouling coating with dynamic surfaces based on regulation of dynamic covalent bonds

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