Dual-Functional Dendrimer Micelles with Glycyrrhizic Acid for Anti-Inflammatory Therapy of Acute Lung Injury

Choi, Myoungjee; Thủy, Lê Thị Thanh; Lee, Mi Kyung; Piao, Chunxian; Choi, Ji Soo; Lee, Minhyung

doi:10.1021/acsami.1c08107

Cited by 22 publications

(20 citation statements)

References 25 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The investigators extracted the abstracts and titles and identified 38 studies that met the inclusion criteria. After reviewing all of the publications, 10 studies were excluded because of missing outcome data ( Ehrhart et al, 2000 ; Tawadros et al, 2007 ; Nader and Baraka, 2012 ; An et al, 2014 ; Wang et al, 2015 ; Liu and Chen, 2016 ; Shen et al, 2017 ; Ni et al, 2019 ; Wang et al, 2019 ; Yang et al, 2019 ), and another 12 studies were excluded because multiple interventions were investigated ( Murakami et al, 2000 ; Lin et al, 2011 ; Li et al, 2014b ; Li et al, 2016a ; Li et al, 2016b ; Baradaran Rahimi et al, 2019 ; Ye et al, 2019 ; Duan et al, 2020 ; Yue et al, 2020 ; Choi et al, 2021 ; Zhang et al, 2021 ; Liu et al, 2022 ). In conclusion, 16 studies were included in this meta-analysis, as described below ( Shi et al, 2007 ; Yang et al, 2011 ; Chen et al, 2014 ; Yang et al, 2014 ; Yuan et al, 2014 ; Wei and Wang, 2017 ; Li et al, 2018a ; Li et al, 2018b ; Luo et al, 2019 ; Ren et al, 2019 ; Zhang et al, 2020 ; Ali et al, 2021 ; Dikmen et al, 2021 ; Li et al, 2021 ; Wang et al, 2021 ; Wu et al, 2021 ) ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies

et al. 2022

View full text Add to dashboard Cite

Background: The clinical efficiency of terpenoids in treating human acute lung injury (ALI) is yet to be determined. The lipopolysaccharide-induced rat model of ALI is a well-established and widely used experimental model for studying terpenoids’ effects on ALI. Using a systematic review and meta-analysis, the therapeutic efficiency of terpenoid administration on the lung wet-to-dry weight ratio in rats was investigated.Methods: Using the Cochrane Library, Embase, and PubMed databases, a comprehensive literature search for studies evaluating the therapeutic efficacy of terpenoids on ALI in rats was conducted. The lung wet-to-dry weight ratio was extracted as the main outcome. The quality of the included studies was assessed using the Systematic Review Center for Laboratory Animal Experimentation’s risk of bias tool.Results: In total, 16 studies were included in this meta-analysis. In general, terpenoids significantly lowered the lung wet-to-dry weight ratio when compared with the control vehicle (p = 0.0002; standardized mean difference (SMD): −0.16; 95% confidence interval (CI): −0.24, −0.08). Subgroup analysis revealed that low dose (≤10 μmol/kg) (p < 0.0001; SMD: −0.68; 95% CI: −1.02, −0.34), intraperitoneal injection (p = 0.0002; SMD: −0.43; 95% CI: −0.66, −0.20), diterpenoid (p = 0.004; SMD: −0.13; 95% CI: −0.23, −0.04), and triterpenoid (p = 0.04; SMD: −0.28; 95% CI: −0.54, −0.01) significantly lowered the lung wet-to-dry weight ratio when compared with the control vehicle.Conclusion: A low dose of diterpenoid and triterpenoid administered intraperitoneally is effective in alleviating ALI. This systematic review and meta-analysis provides a valuable mirror for clinical research aiming at the advancement of terpenoids for preventive and therapeutic use.Systematic Review Registration: CRD42022326779

show abstract

Section: Resultsmentioning

confidence: 99%

Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies

et al. 2022

View full text Add to dashboard Cite

show abstract

“…GA is the main active ingredient in licorice, which is a traditional Chinese medicine that is safe and non-toxic . It is a natural anti-inflammatory and antibacterial drug commonly applied in the treatment of acute lung injury, chronic pneumonia, and pulmonary fibrosis. ,, Although GA does appear to be used in many cases to treat respiratory diseases, it is unclear whether it cures CRD in chickens caused by MG. In this study, GA was adopted in the cellular model and the chick model to investigate its effect on MG infection and molecular mechanism, to provide a theoretical basis for GA in clinical treatment of CRD, and for further development of safe, effective, and cheap antibiotic alternatives.…”

Section: Discussionmentioning

confidence: 99%

Glycyrrhizic Acid against Mycoplasma gallisepticum-Induced Inflammation and Apoptosis Through Suppressing the MAPK Pathway in Chickens

Wang

Luo

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

Mycoplasma gallisepticum (MG) is the primary pathogen of chronic respiratory diseases (CRDs) in chickens. In poultry production, antibiotics are mostly used to prevent and control MG infection, but the drug resistance and residue problems caused by them cannot be ignored. Glycyrrhizic acid (GA) is derived from licorice, a herb traditionally used to treat various respiratory diseases. Our study results showed that GA significantly inhibited the mRNA and protein expression of pMGA1.2 and GapA in vitro and in vivo. Furthermore, the network pharmacology study revealed that GA most probably resisted MG infection through the MAPK signaling pathway. Our results demonstrated that GA inhibited MG-induced expression of MMP2/MMP9 and inflammatory factors through the p38 and JUN signaling pathways, but not the ERK pathway in vitro. Besides, histopathological sections showed that GA treatment obviously attenuated tracheal and lung damage caused by MG invasion. In conclusion, GA can inhibit MG-triggered inflammation and apoptosis by suppressing the expression of MMP2/MMP9 through the JNK and p38 pathways and inhibit the expression of virulence genes to resist MG. Our results suggest that GA might serve as one of the antibiotic alternatives to prevent MG infection.

show abstract

“…Luciferase assay showed that the in vitro plasmid DNA delivery efficiency of pDNA/PamChol Cur delivered to lung epithelial cells was significantly higher than that of the pDNA group and exerted anti-inflammatory effects by inhibiting the nuclear translocation of NF-κB (Kim et al, 2019). Choi et al (2021) used cholesterol coupled to histidine and arginine grafted polyamidoamine (PamHR) to form micelles (PamHRchol), followed by a reaction with glycyrrhizic acid (GA) to produce mixed dendritic micelles (PamHRchol/GA), and the HO-1 gene was introduced into the lungs of ALI mice as a therapeutic gene. Dendrimeric micelles have higher gene delivery efficiency compared to free GA.…”

Section: Nanocapsulementioning

confidence: 99%

Pharmacologic therapies of ARDS: From natural herb to nanomedicine

et al. 2022

View full text Add to dashboard Cite

Acute respiratory distress syndrome (ARDS) is a common critical illness in respiratory care units with a huge public health burden. Despite tremendous advances in the prevention and treatment of ARDS, it remains the main cause of intensive care unit (ICU) management, and the mortality rate of ARDS remains unacceptably high. The poor performance of ARDS is closely related to its heterogeneous clinical syndrome caused by complicated pathophysiology. Based on the different pathophysiology phases, drugs, protective mechanical ventilation, conservative fluid therapy, and other treatment have been developed to serve as the ARDS therapeutic methods. In recent years, there has been a rapid development in nanomedicine, in which nanoparticles as drug delivery vehicles have been extensively studied in the treatment of ARDS. This study provides an overview of pharmacologic therapies for ARDS, including conventional drugs, natural medicine therapy, and nanomedicine. Particularly, we discuss the unique mechanism and strength of nanomedicine which may provide great promises in treating ARDS in the future.

show abstract

Dual-Functional Dendrimer Micelles with Glycyrrhizic Acid for Anti-Inflammatory Therapy of Acute Lung Injury

Cited by 22 publications

References 25 publications

Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies

Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies

Glycyrrhizic Acid against Mycoplasma gallisepticum-Induced Inflammation and Apoptosis Through Suppressing the MAPK Pathway in Chickens

Pharmacologic therapies of ARDS: From natural herb to nanomedicine

Contact Info

Product

Resources

About