Dual function of coronatine as a bacterial virulence factor against plants: possible COI1–JAZ-independent role

Egoshi, Syusuke; Takaoka, Yousuke; Saito, Hiroaki; Nukadzuka, Yuuki; Hayashi, Kenshi; Ishimaru, Yasuhiro; Yamakoshi, Hiroyuki; Dodo, Kosuke; Sodeoka, Mikiko

doi:10.1039/c5ra20676f

Cited by 16 publications

(21 citation statements)

References 35 publications

(61 reference statements)

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“…Xie's group reported that the amino acid conjugates, JA-Leu, JA-Val, JA-Met, and JA-Ala, function as endogenous jasmonates as well as JA-Ile [58]. This result will be useful for further molecular design of COI1-JAZ agonists, the spatial limitations of the ligand-binding pocket of COI1 having been demonstrated-a finding supported by the molecular docking study by Ueda' s group [59].…”

Section: Other Chemicals Involved In the Tuned Regulation Of Jasmonatmentioning

confidence: 74%

Recent Advances in Plant Chemical Biology of Jasmonates

Ueda

Kaji

Kozaki

2020

IJMS

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Lipid-derived plant hormone jasmonates are implicated in plant growth, reproductive performance, senescence, secondary metabolite productions, and defense against both necrotrophic pathogens and feeding insects. A major jasmonate is (+)-7-iso-jasmonoyl-l-isoleucine (JA-Ile), which is perceived by the unique COI1-JAZ coreceptor system. Recent advances in plant chemical biology have greatly informed the bioscience of jasmonate, including the development of chemical tools such as the antagonist COR-MO; the agonist NOPh; and newly developed jasmonates, including JA-Ile-macrolactone and 12-OH-JA-Ile. This review article summarizes the current status of plant chemical biology as it pertains to jasmonates, and offers some perspectives for the future.

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Section: Other Chemicals Involved In the Tuned Regulation Of Jasmonatmentioning

confidence: 74%

Recent Advances in Plant Chemical Biology of Jasmonates

Ueda

Kaji

Kozaki

2020

IJMS

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“…We therefore used a stereochemical isomer of 3 to develop a subtype-selective PPI stabilizer between COI1 and JAZ. Optically pure samples of the building blocks of 3 , (+)-coronamic acid (CMA, 4 ) 29 , and (+)-coronafacic acid (CFA, 5 ) 30 , were coupled to give naturally occurring 3 , the enantiomer ent 3 , and the stereochemical hybrid isomers, CFA- ent CMA ( 6 ) and ent CFA-CMA ( ent 6 ), respectively (Fig. 1a ) 29 .…”

Section: Resultsmentioning

confidence: 99%

A rationally designed JAZ subtype-selective agonist of jasmonate perception

et al. 2018

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The phytohormone 7-iso-(+)-jasmonoyl-L-isoleucine (JA-Ile) mediates plant defense responses against herbivore and pathogen attack, and thus increases plant resistance against foreign invaders. However, JA-Ile also causes growth inhibition; and therefore JA-Ile is not a practical chemical regulator of plant defense responses. Here, we describe the rational design and synthesis of a small molecule agonist that can upregulate defense-related gene expression and promote pathogen resistance at concentrations that do not cause growth inhibition in Arabidopsis. By stabilizing interactions between COI1 and JAZ9 and JAZ10 but no other JAZ isoforms, the agonist leads to formation of JA-Ile co-receptors that selectively activate the JAZ9-EIN3/EIL1-ORA59 signaling pathway. The design of a JA-Ile agonist with high selectivity for specific protein subtypes may help promote the development of chemical regulators that do not cause a tradeoff between growth and defense.

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“…The structure of coronatine consists of coronafacic acid (+)-CFA (an analog of MeJA) and coronamic acid, joined by an amide bond between the acid group of CFA and the amino group of coronamic acid, and so (+)-CFA could be considered as a structural mimic of (+)-7-iso-JA (Supplemental Fig. S8; Egoshi et al, 2016). Treatment of wild type with (+)-CFA dramatically suppressed LR formation, with only slight effects on primary root growth (Fig.…”

Section: Coronafacic Acid Was An Lr-preferential Auxin Inhibitormentioning

confidence: 99%

Jasmonic Acid Inhibits Auxin-Induced Lateral Rooting Independently of the CORONATINE INSENSITIVE1 Receptor

et al. 2018

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Plant root systems are indispensable for water uptake, nutrient acquisition, and anchoring plants in the soil. Previous studies using auxin inhibitors definitively established that auxin plays a central role regulating root growth and development. Most auxin inhibitors affect all auxin signaling at the same time, which obscures an understanding of individual events. Here, we report that jasmonic acid (JA) functions as a lateral root (LR)-preferential auxin inhibitor in Arabidopsis () in a manner that is independent of the JA receptor, CORONATINE INSENSITIVE1 (COI1). Treatment of wild-type Arabidopsis with either (-)-JA or (+)-JA reduced primary root length and LR number; the reduction of LR number was also observed in mutants. Treatment of seedlings with (-)-JA or (+)-JA suppressed auxin-inducible genes related to LR formation, diminished accumulation of the auxin reporter, and inhibited auxin-dependent DII-VENUS degradation. A structural mimic of (-)-JA and (+)-coronafacic acid also inhibited LR formation and stabilized DII-VENUS protein. COI1-independent activity was retained in the double mutant of and () but reduced in the single mutant. These results reveal JAs and (+)-coronafacic acid to be selective counter-auxins, a finding that could lead to new approaches for studying the mechanisms of LR formation.

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Dual function of coronatine as a bacterial virulence factor against plants: possible COI1–JAZ-independent role

Abstract: A phytotoxin coronatine has a dual mode of action, triggering stomatal reopening through COI1–JAZ-dependent and independent pathways.

Cited by 16 publications

References 35 publications

Recent Advances in Plant Chemical Biology of Jasmonates

Recent Advances in Plant Chemical Biology of Jasmonates

A rationally designed JAZ subtype-selective agonist of jasmonate perception

Jasmonic Acid Inhibits Auxin-Induced Lateral Rooting Independently of the CORONATINE INSENSITIVE1 Receptor

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