Dual-function microneedle array for efficient photodynamic therapy with transdermal co-delivered light and photosensitizers

Zhao, Huiting; Wang, Xu; Geng, Zhanhui; Liang, Naixin; Li, Qin; Hu, Xiaoming; Wei, Zewen

doi:10.1039/d2lc00505k

Cited by 7 publications

(6 citation statements)

References 49 publications

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“…Adapted with permission from the Royal Society of Chemistry 2022. [127] illuminated a few hundred micrometers close to its fiber end (Figure 7f). When the light was coupled only at a specified angle, site-selective illumination was achieved by simply tuning the input angle (e.g., at 3, 9, and 12.5°in Figure 7g).…”

Section: Optogeneticsmentioning

confidence: 99%

“…[125,126] Interestingly, a re-cent study explored the possibility of integrating the dual functionalities into a single microneedle array platform for effective transdermal co-delivery of photosensitizer and light. [127] Its light guiding bodies were fabricated by molding a soft polymer, polyvinyl alcohol, and its photosensitizer (temoporfin)-loading tip was developed by sodium hyaluronate molding (Figure 8g). Once fully inserted into the skin, its photosensitizer-loading tips quickly dissolved into the deep skin layer, leaving the remaining transparent microneedle body in place to further guide PDT light into the same skin layer for treatment (Figure 8h).…”

Section: Photodynamic Therapymentioning

confidence: 99%

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Fiber Optic Devices for Diagnostics and Therapy in Photomedicine

Hu,

Minzioni,

Hui

et al. 2024

Advanced Optical Materials

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Photonic technologies have made enormous impacts on modern medicine, advancing disease diagnostics and treatments as well as health monitoring. A long‐standing challenge in the use of light and its widespread effects in photomedicine is the finite penetration of light in tissues. However, judiciously engineered optical fibers helped overcome this challenge and advance light delivery to deep tissues with spatial precision and desired accessibility. In recent years, the development of photonic technologies including optical biomaterials, fiber functionalization, and biomedical device innovations has greatly expanded the scope of light‐based healthcare. Here, the fundamentals and materials of fiber optics to endow themselves with biocompatibility, flexibility, and diverse functionalities required for long‐term implantation are overviewed. The design strategies of lab‐on‐fiber techniques, operation requirements to construct fiber optic sensors, and their health monitoring applications as wearable and implantable devices are presented. The use of fiber optics in major light‐based therapeutic modalities including optogenetics, photodynamic therapy, photobiomodulation, photochemical cross–linking, and photothermal therapy is illustrated to enhance their effectiveness, specificity, and feasibility. In short, a comprehensive review is provided on the fiber optic techniques and the latest photonic devices, which are envisioned to evolve photomedicine in clinical and point‐of‐care practices.

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Section: Optogeneticsmentioning

confidence: 99%

Section: Photodynamic Therapymentioning

confidence: 99%

Fiber Optic Devices for Diagnostics and Therapy in Photomedicine

Hu,

Minzioni,

Hui

et al. 2024

Advanced Optical Materials

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“…However, current delivery methods, such as intravenous injection of photosensitizers or direct illumination of the skin, have limitations. Intravenous injection can cause photosensitizer accumulation in the circulatory system, leading to harmful effects on healthy tissues (Zhao et al, 2022). Light delivery inside the skin tissue is also limited due to its scattering and absorption.…”

Section: Introductionmentioning

confidence: 99%

“…This led to the development of a height fixation device for blue light delivery on a culture dish and an LED system to conduct the cell apoptosis using an MNA array (Wu et al, 2022). Furthermore, Zhao et al proposed a dual-function dissolvable MNA for delivering light as well as drugs with reduced therapeutic irradiance resulting in limited skin damage (Zhao et al, 2022). Yang et.…”

Section: Introductionmentioning

confidence: 99%

Optical design of a tunable microneedle array for photodynamic therapy of metastatic melanomas

Dasgupta,

Berwal,

Singh

et al. 2024

Nanofab

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The need for photodynamic therapy is increasing with the rise of skin cancer melanoma detection. However, low penetration depth of light in the UV range and higher scattering of skin tissues cause harsh clinical practices and reduced irradiance for the activation of chemicals such as photosensitizers to facilitate cell necrosis of malignant tumors. In this paper, a tunable microlens integrated on a microneedle array is designed for variable focusing to reduce melanomas at multiple sites with an improved intensity for reactive oxygen species production. A light distribution of 36% percent of the input intensity is achieved at the targeted distance of 4.35 mm for blue light. Red light attained a light distribution of 13% of the input intensity at a targeted distance of 6.5 mm. Designing such a light, delivery-based in-vivo biomedical device is of extreme importance for photodynamic therapy of skin cancer on and beyond the epidermal tissue layer.

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“…Nevertheless, the clinical effectiveness of transdermally delivering therapeutic light for treating superficial disease has not yet been confirmed. Moreover, the concept of transdermal delivering both photosensitizer and guiding therapeutic light simultaneously has also been raised 37 . Despite that transdermal delivery of either photosensitizer or therapeutic light has respectively been verified as beneficial advances for improving light therapy, transdermal co-delivery of photosensitizer and therapeutic light by a full-function portable device to treat superficial diseases is yet to be realized.…”

mentioning

confidence: 99%

Miniaturized all-in-one microneedle device for point of care light therapy

Zhao,

Wang,

Xiong

et al. 2024

npj Flex Electron

Self Cite

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Light therapies have been applied to millions of patients for treating many kinds of diseases, especially superficial ones. Currently, mainstream light therapies utilize the combined effects of photosensitizers and light to either remove disordered tissue or promote the growth of healthy tissue. Adverse effects of light therapy, including metabolic burden caused by circulatory photosensitizer and skin damage induced by high irradiance light, are yet to be addressed. This study provides a Miniaturized all-in-one Light therapy Device (MiLD). All components required for light therapy, including dual-function microneedles, LED array, control circuit, and battery are integrated together to form a miniaturized portable device with 2 cm in length, 1.7 cm in width, 1.2 cm in height, and 3.6 g in weight. The all-in-one design and patch-to-cure operation of MiLD enables the successful demonstration of point-of-care light therapy. Satisfactory therapeutic effects have been verified in mice on both types of light therapy. Meanwhile, transdermally co-delivering both photosensitizer and light in situ fully avoids photosensitizer accumulation in blood and remarkably reduces the irradiance of light, therefore significantly alleviating metabolic burden and light-induced skin damage. Overall, the MiLD lays the technical foundation of point-of-care light therapy with its miniaturized all-in-one design, simple patch-to-cure operation, satisfactory therapeutic effects, and minimum adverse effects.

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Dual-function microneedle array for efficient photodynamic therapy with transdermal co-delivered light and photosensitizers

Abstract: Photodynamic therapy (PDT), as a globally accepted method for treating different forms of skin or mucosa disorders, requires efficient co-delivery of photosensitizer and corresponding therapeutic light. The adverse effects of...

Cited by 7 publications

References 49 publications

Fiber Optic Devices for Diagnostics and Therapy in Photomedicine

Fiber Optic Devices for Diagnostics and Therapy in Photomedicine

Optical design of a tunable microneedle array for photodynamic therapy of metastatic melanomas

Miniaturized all-in-one microneedle device for point of care light therapy

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