Dual-energy X-ray absorptiometry pitfalls in Thalassemia Major

Pellegrino, Fabio; Zatelli, Maria Chiara; Bondanelli, Marta; Carnevale, Aldo; Cittanti, Corrado; Fortini, Monica; Gamberini, Maria Rita; Giganti, Melchiore; Ambrosio, Maria Rosaria

doi:10.1007/s12020-019-02003-x

Cited by 17 publications

(21 citation statements)

References 99 publications

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“…Early diagnosis requires accurate estimation of BMD via densitometry. Interpretation of dual-energy X-ray absorptiometry (DXA) may be confounded in thalassaemia due to short stature and spinal deformities caused by medullary expansion, bone dysplasia and the increased rate of degenerative vertebral disc disease in TM patients [120,121]. Artefact from hepatic iron loading might also derange DXA analysis [122].…”

Section: Osteoporosismentioning

confidence: 99%

“…Alternative modalities for assessing bone microarchitecture in thalassaemia include trabecular bone structure (TBS) analysis-a textural assessment derived from DXA images-and quantitative computed tomography (QCT). These alternative methods remain limited by the distinctive profile of thalassaemia osteopathy and, in the case of QCT, by the amount of vertebral iron deposition [121,123].…”

Section: Osteoporosismentioning

confidence: 99%

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Investigation and Management of Endocrinopathies in Thalassaemia Major

Al-Hourani¹,

Hua²,

De³

2021

Human Blood Group Systems and Haemoglobinopathies

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A combination of sub-therapeutic chelation and subsequent iron overload are regarded as the principal drivers of endocrine dysfunction in thalassaemia. The clinical presentation of endocrine complications and their timing of onset can be highly variable, in part due to population heterogeneity but also variation in chelation strategies. Endocrinopathies commonly associated with thalassaemia include: growth delay; pubertal delay; gonadal dysfunction; thyroid disorders; parathyroid and adrenal gland impairment; impaired bone metabolism; and type 2 diabetes mellitus. In this chapter we summarise the main presentations of endocrine disorder in thalassaemia, summarising their epidemiology, clinical presentation and pathophysiologic basis. Furthermore, we review screening, monitoring and treatment strategies, with particular regard to the UK Thalassaemia Society’s 2016 National Standards.

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Section: Osteoporosismentioning

confidence: 99%

Section: Osteoporosismentioning

confidence: 99%

Investigation and Management of Endocrinopathies in Thalassaemia Major

Al-Hourani¹,

Hua²,

De³

2021

Human Blood Group Systems and Haemoglobinopathies

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“…Several mechanisms have been also proposed to explain specific protection against malaria-induced • Enhanced removal of parasite-infected RBC [45] • Reduced invasion and growth of P. falciparum parasites [119,120] • Reduced pathogenicity through reduced cytoadherence or resetting [121] • Enhanced antibody binding and subsequent clearance of infected variant RBCs [110] • Increased phagocytosis of ring-parasitised variant RBCs [45,102,122] • Severe P. falciparum malaria To our knowledge, no studies have investigated the risk of severe malaria in patients with β-thalassaemia.…”

Section: β-Thalassemiamentioning

confidence: 99%

Section: Osteoporosismentioning

confidence: 99%

Section: Osteoporosismentioning

confidence: 99%

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Human Blood Group Systems and Haemoglobinopathies

Erhabor¹,

Munshi²

2021

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He completed the University of Greenwich, UK Specialist Training in Blood Transfusion and Laboratory Quality Management System. He holds a Specialist Certificate in Transfusion Science Practice from the British Blood Transfusion Society (BBTS). He is also an alumnus of Francis Tuttle College of Technology in Oklahoma, USA. His teaching experience spans both the African continent and Europe. Dr. Osaro is the chair of the equality and diversity working group of the BBTS and recipient of the Margaret Kenwright Scientist award from the same organization. He is a registered portfolio verifier/examiner for the Institute of Biomedical Science of London. He has authored five scientific books and five book chapters. A well-published contributor with more than 160 published articles in the fields of infectious diseases, occupational health, immunohematology, and transfusion medicine, Dr. Osaro is also an editorial board member and reviewer for several international scientific journals.

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