Dual-energy CT to detect recurrent HCC after TACE: Initial experience of color-coded iodine CT imaging

Iodine concentration as a perfusion surrogate marker in oncology: Further elucidation of the underlying mechanisms using Volume Perfusion CT with 80 kVp

“…So far, only a few studies have calculated iodine-related attenuation values or iodine concentrations in solid tumours or lymphoma. Lee JA et al applied colour-coded iodine CT maps in HCC and documented a median HU value of 65.13 ± 26.10 [15]. In a VX2 carcinoma rabbit model after radiofrequency ablation, the residual tumour showed a concentration of 1.83 ± 0.21 mg/mL concentration in the arterial phase [24] and, therefore, similar to our results.…”

“…Several studies already indicated the feasibility of this method to distinguish malignant from benign processes [13,14]. Recent work by Lee et al showed that DECT arterial phase scans performed equally compared to conventional multi-phase CT in detecting HCC recurrence after TACE, while reducing the applied radiation dose [15].…”

Impact of dual-energy CT prior to radioembolization (RE)

“…The significant benefits of DECT were previously demonstrated in numerous studies (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Advantages were evident in the qualitative and quantitative assessment of tumor and organ perfusions, tissue characterization, or the improved plaque detection and characterization.…”

Clinical applications for dual energy CT versus dynamic contrast enhanced CT in oncology

“…Especially in gastrointestinal imaging, this reduction of scans would be of great benefit with regard to radiation safety and patient comfort. As in VPCT, several studies point out the high interobserver agreement in diagnostic findings [47][48][49].…”